Preparing Digitized Cervigrams for Colposcopy Research and Education: Determination of Optimal Resolution and Compression Parameters

Jerónimo, José; Long, Rodney; Neve, Leif; Ferris, Daron G.; Noller, Kenneth L.; Spitzer, Mark; Mitra, Sunanda; Guo, Junjie; Nutter, Brian; Castle, Phil; Herrero, Rolando; Rodríguez, Ana Cecilia; Schiffman, Mark

doi:10.1097/01.lgt.0000192696.93172.ae

Cited by 11 publications

(7 citation statements)

References 5 publications

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“…9 Software developed by the National Institutes of Health was used to access and evaluate the images through the Internet. 10 Evaluators were masked to clinical data, because no clinical information was provided.…”

Section: Methodsmentioning

confidence: 99%

Interobserver Agreement in the Assessment of Components of Colposcopic Grading

Massad

Jerónimo

Schiffman

2008

Obstetrics & Gynecology

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Section: Methodsmentioning

confidence: 99%

Interobserver Agreement in the Assessment of Components of Colposcopic Grading

Massad

Jerónimo

Schiffman

2008

Obstetrics & Gynecology

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“…After digitization and compression (14), images were evaluated on-line using software developed by the National Institutes of Health (15). The evaluators were 20 colposcopists (12 general gynecologists and 8 gynecologist-oncologists) with at least 10 years of experience in colposcopy and prior research in cervical cancer prevention.…”

Section: Methodsmentioning

confidence: 99%

The Accuracy of Colposcopic Grading for Detection of High-Grade Cervical Intraepithelial Neoplasia

Massad

Jerónimo

Katki

et al. 2009

Journal of Lower Genital Tract Disease

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131

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Objective To relate aspects of online colposcopic image assessment to the diagnosis of grades 2 and 3 cervical intraepithelial neoplasia (CIN2+). Methods To simulate colposcopic assessment, digitized cervical images were obtained at enrollment after acetic acid application from 919 women referred for equivocal or minor cytologic abnormalities into the ASCUS-LSIL Triage Study. For each, two randomly assigned evaluators from a pool of 20 colposcopists assessed images using a standardized tool on-line. We calculated the accuracy of these assessments for predicting histologic CIN2+ over the two years of study. For validation, a subset of on-line results was compared to same-day enrollment colposcopic assessments. Results Identifying any acetowhite lesion in images yielded high sensitivity: 93% of women with CIN2+ had at least one acetowhite lesion. However, 74% of women without CIN2+ also had acetowhitening, regardless of human papillomavirus (HPV) status. The sensitivity for CIN2+ of an on-line colpophotographic assessment of high grade disease was 39%. The sensitivity for CIN2+ of a high grade diagnosis by Reid Index scoring was 30%, and individual Reid Index component scores had similar levels of sensitivity and specificity. The performance of on-line assessment was not meaningfully different from that of same-day enrollment colposcopy, suggesting that these approaches have similar utility. Conclusion Finding acetowhite lesions identifies women with CIN2+, but using subtler colposcopic characteristics to grade lesions is insensitive. All acetowhite lesions should be assessed with biopsy to maximize sensitivity of colposcopic diagnosis with good specificity.

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“…Such a situation was observed in almost half of the patients (46.7%). Comparing these observations to colposcopic pictures of cervical cancer marginal mucosae, the latter was pale rosy to rosy [ 25 ]. Hyperaemia of the underlying tissues and resulting redness of mucosae surrounding cervical tumours was stated in cases of co-existing colpitis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Under such circumstances the irregular shapes of cervical mucosal margins and their unclear transition into a colposcopically correct picture of the vaginal portion of uterine cervix become evident [ 22 ]. In extensive exophytic cervical tumours, a colposcopic picture of healthy marginal mucosae may be impossible to obtain [ 22 , 25 ]. Analysis of reports concerning the effectiveness of dermatoscopy in the diagnosis of genital tumours revealed that in cases of invasive vulvar tumours the marginal mucosa contain strongly branched, dilated and elongated pathologic vessels, similar to the margins of invasive OSCC seen with direct oral microscopy and cervical cancers seen in colposcopy.…”

Section: Discussionmentioning

confidence: 99%

Application of direct oral microscopy in evaluating mucosal margins around invasive oral squamous cell carcinoma

Chomik

Michcik

Michajłowski

et al. 2015

pdia

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IntroductionDirect oral microscopy constitutes a novel, non-invasive diagnostic technique, which aids clinical examination of the oral cavity. The oral mucosa is examined at multiple magnifications and features such as sub-epithelial mucosal vessels, surface patterns, colour tone, transparency and the exact demarcation of mucosal lesions are estimated. The incidence of oral squamous cell carcinoma (OSCC) oscillates between 1.9% and 3.5%, which makes it the eighth most common carcinoma occurring around the world and in Poland. The 5-year survival rates oscillate between 20% and 30%.AimThe aim of the study was to evaluate clinically unchanged mucosal margins around OSCC by direct oral microscopy. The authors approached the question whether the borders of mucosal margins around OSCC established via direct oral microscopy differ from those established based on clinical examination.Material and methodsFifteen patients diagnosed with OSCC were enrolled. Patients were first clinically examined to evaluate the extent of the tumour and to plan resection margins. Eventually, direct oral microscopy was performed to establish the width of the subclinically unchanged mucosal margins based on a standard picture of healthy oral mucosae, followed by comparison with those established by clinical evaluation.ResultsHistopathologic results of biopsies from areas indicated by direct oral microscopy revealed dysplasia in 86.7% of patients, whereas biopsies from areas indicated by clinical examination revealed dysplasia only in 40% of individuals, resulting in the need for widening of mucosal margins.ConclusionsDirect oral microscopy enables detection of dysplasia within clinically unaltered mucosal margins around OSCC, which results in more precise establishing of resection boundaries, contributing to improvement of resection totality.

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Preparing Digitized Cervigrams for Colposcopy Research and Education: Determination of Optimal Resolution and Compression Parameters

Abstract: Our results suggest that 2,000 dpi is the optimal level for digitizing cervigrams, and the optimal compression ratio is 50:1 using a novel wavelet-based technology. At these parameters, pictures have no significant differences with the gold standard.

Cited by 11 publications

References 5 publications

Interobserver Agreement in the Assessment of Components of Colposcopic Grading

Interobserver Agreement in the Assessment of Components of Colposcopic Grading

The Accuracy of Colposcopic Grading for Detection of High-Grade Cervical Intraepithelial Neoplasia

Application of direct oral microscopy in evaluating mucosal margins around invasive oral squamous cell carcinoma

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