2018
DOI: 10.1007/s11695-018-3341-6
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Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial

Abstract: This study shows that preperitoneal local anesthesia with bupivacaine results in a reduction in opioid consumption and postoperative pain and seems to lower the incidence rate of chronic postsurgical pain after laparoscopic bariatric surgery.

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Cited by 22 publications
(16 citation statements)
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“…Ultrasound-guided transversus abdominis plane block can decrease pain scores and opioid requirement, and improve ambulation after bariatric surgery [ 134 ]. Infiltration of bupivacaine 0.5% before incision results in a reduction in opioid consumption and postoperative pain [ 135 ]. Other promising strategies are intraperitoneal instillation of bupivacaine [ 136 ] and erector spinae plane block [ 137 ].…”
Section: Results: Evidence Base and Recommendationsmentioning
confidence: 99%
“…Ultrasound-guided transversus abdominis plane block can decrease pain scores and opioid requirement, and improve ambulation after bariatric surgery [ 134 ]. Infiltration of bupivacaine 0.5% before incision results in a reduction in opioid consumption and postoperative pain [ 135 ]. Other promising strategies are intraperitoneal instillation of bupivacaine [ 136 ] and erector spinae plane block [ 137 ].…”
Section: Results: Evidence Base and Recommendationsmentioning
confidence: 99%
“…In addition to decreased inhalant dosing, the need for rescue analgesia, including opioids, is decreased with the use of local/regional analgesia. In humans (Bergese et al, 2012;Blanco, Ansari, & Girgis, 2015;Boerboom et al, 2018;Candiotti, 2012;Lombardi, 2014;Malik, Kaye, Belani, & Urman, 2017;Marques et al, 2014;Stokes et al, 2017) and dogs/ cats (Benito et al, 2016;Carpenter et al, 2004;Flecknell, Kirk, Liles, Hayes, & Dark, 1991;Myrna et al, 2010;Perez et al, 2013;Savvas et al, 2008;Wenger, Moens, Jäggin, & Schatzmann, 2005), local anaesthetics significantly decrease the opioid requirements for intraoperative anti-nociception and postoperative analgesia. Using local anaesthetics to decrease opioid use could be very beneficial in both human and veterinary patients, not only because of the desire to reduce potential opioid-mediated adverse effects, such as dysphoria, vomiting and nausea, but also because the availability of potent opioids may be limited due to legislation, production or country/region.…”
mentioning
confidence: 99%
“…The intensity and duration of pain in recovery is an important indicator of the likelihood of chronic pain development in humans (Althaus et al, 2018;Boerboom et al, 2018;de Brito, Omanis, Ashmawi, & Torres, 2012;Jin et al, 2016;Rashiq & Dick, 2014;Voscopoulos & Lema, 2010). The fact that human patients with local anaesthetic drugs included in the analgesic protocols were less likely to develop both postoperative and chronic pain is a very compelling reason to utilize local/regional blockade (Boerboom et al, 2018;de Brito et al, 2012;Rashiq & Dick, 2014). Although no studies are available for animals, the authors suggest that, based on the similarity of the mammalian pain pathway across species, the same result could be extrapolated for veterinary patients, including dogs and cats.…”
mentioning
confidence: 99%
“…Lidocaine plasma concentrations were below toxic levels when 8 mg/kg was instilled intraperitoneally and 2 mg/kg was injected at the incision site . (Boerboom et al 2018;Ruiz-Tovar et al, 2016), including caesarean section (Patel et al, 2017).…”
Section: Testicular Blockmentioning
confidence: 99%