Prepidil® compared to Propess® for cervical ripening

Induction of Labor with Dinoprostone Vaginal Insert; Is it Safe and Effective in Term Pregnancy with Premature Rupture of Membranes?

“…Also, it was reported that there was no statistical difference in terms of operative vaginal delivery between two groups. 28 There was no significant difference in vaginal delivery ratio between patients with intact membranes and PROM patients in our study. Time to vaginal delivery was found to be better correlated with parity in PROM patients whereas it was better correlated with initial bishop scores in patients with intact membranes.…”

The Effect of Parity on Labor Induction with Prostaglandin E2 Analogue (Dinoprostone): An Evaluation of 2090 Cases

“…There are many studies in the literature addressing the effect of dinoprostone as a cervical ripening and labor induction agent and the findings demonstrated that cervical ripening with dinoprostone-slowrelease vaginal insert was associated with a high rate of women entering active labor [9,[11][12][13][21][22][23]. But most of these studies did not evaluate the effect of parity on the success of labor induction with dinoprostone.…”

“…Food and Drug Administration approved dinoprostone (PGE2) vaginal (Propess TM Dinoprostone vaginal delivery system, FerringIlac Sanayi, Istanbul, Turkey) in 1995 for cervical ripening, which releases 10 mg of dinoprostone over 12 hours. The effects and properties of PGE2 (dinoprostone) have been investigated and there are many studies in the literature comparing the efficacy of the different formulations available in the market [8][9][10][11][12][13][14][15][16][17][18]. Unfortunately, many of these studies were conducted without regard to parity [9,10,12].…”

Utilisation du dispositif vaginal Propess® dans le déclenchement du travail : efficacité et innocuité

“…Les premiers travaux [4] étaient surtout axés sur le mécanisme de fonctionnement, étudiant par exemple le dosage des prostaglandines in vivo et sanguines [10,12], afin de déterminer la posologie adéquate. D'autres études ont évalué l'efficacité par rapport aux autres types de prostaglandines [13,14].…”

“…Il est multiplié par 3,5 après déclenchement par Propess ® , et est le facteur le plus important à l'origine des césariennes après les anomalies du rythme cardiaque foetal, souvent consécutives à un phé-nomène d'hypercinésie utérine [20]. Les données de la littéra-ture montrent que ce taux n'est cependant pas majoré lorsqu'il est comparé aux autres prostaglandines [6,14]. Ces anomalies du rythme cardiaque foetal disparaissent assez rapidement à l'ablation du dispositif Propess ® , ce qui en constitue le principal avantage par rapport aux autres gels.…”