PReS-FINAL-2292: Hypogonadism and osteoporosis among adolescents with systemic lupus erythematosus

El‐Ghoneimy, Dalia; Awwaad, Khaled S; Elhadidy, Eman Ibrahim; Achour, A.

doi:10.1186/1546-0096-11-s2-p282

Cited by 2 publications

(2 citation statements)

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“…Gonadal dysfunction has been suggested to be a prominent risk factor for low BMD; an irradiation treatment is likely to play a major role in this process, thereby affecting any stage of the hypothalamic–pituitary–gonadal axis [ 41 ]. Although some studies have suggested that hypogonadism is a possible factor for low bone mass in other disease categories such as gastrointestinal and rheumatoid diseases, the evidence is scarce and further research is needed in this area [ 42 , 43 ]. In this study, we observed low Z-scores for female estradiol in different disease categories and hypogonadism was even more prominent in female patients with LSBMD Z-scores ≤ −2.0.…”

Section: Discussionmentioning

confidence: 99%

Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility

Kim,

Kim

et al. 2024

Biomedicines

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This study aimed to investigate the impact of hypogonadism on bone mineral density (BMD) in children and adolescents with chronic diseases to determine the relationship between sex hormones and BMD. This retrospective study included 672 children and adolescents with chronic diseases such as hemato-oncologic, rheumatoid, gastrointestinal, and endocrinologic diseases. The relationship between the sex- and Tanner-stage-matched Z-scores for sex hormones and the sex- and age-matched lumbar spine BMD (LSBMD) Z-scores was evaluated. Adjustments were made for confounders such as underlying diseases, age at diagnosis, and age- and sex-matched body mass index Z-scores. Patients had a mean LSBMD Z-score of −0.55 ± 1.31. In the multivariate regression analysis, male testosterone showed a positive association with the LSBMD Z-score (p < 0.001), whereas female estradiol, luteinizing hormone, and follicular-stimulating hormone showed no significant association with the LSBMD Z-scores. In the male group, the testosterone level was associated with LSBMD Z-scores > −1.0 (p < 0.001), > −2.0 (p < 0.001), and > −3.0 (p = 0.002), while the estradiol level was associated with LSBMD Z-scores > −2.0 (p = 0.001) and > −3.0 (p = 0.002) in the female group. In conclusion, sex hormones are associated with BMD in children and adolescents with chronic diseases. Therefore, various measures may be necessary to predict future skeletal problems and improve bone health in these patients.

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Section: Discussionmentioning

confidence: 99%

Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility

Kim,

Kim

et al. 2024

Biomedicines

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“…Thyroid autoimmune diseases have been associated with various rheumatological diseases, including SLE, caused by an immune response, both humoral and cell-mediated, resulting in tissue damage localized in the thyroid [3]. The two diseases may occur successively or simultaneously [4].…”

Section: Introductionmentioning

confidence: 99%

Association between Systemic Lupus Erythematosus and Autoimmune Thyroid Dysfunction in Pediatric Population Cross Sectional Study, Single Center Experience

Shamma

Soliman

Abdelfattah

et al. 2023

Preprint

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Background Thyroid disease is more frequent in patients with systemic lupus erythematosus (SLE) than in the general population. The main purpose of this study is to evaluate the occurrence of immunological thyroid dysfunctions in Egyptian children with SLE in a single center and its relation to the disease activity and duration. Methods This is a cross-sectional observational study. The study included 50 children and adolescents with SLE. All patients were subjected to complete history taking, thorough physical examination. Thyroid profile, anti-thyroglobulin and anti-thyroid peroxidase antibodies were assayed using an enzyme-linked immunosorbent assay (ELISA) technique. Results Out of 50 patients, six were males (12%), and 44 were females (88%), with female to male ratio (F: M = 7: 1). Their ages ranged from 5–17 years, with a median of 12 years. Thirty-two of patients (64%) had thyroid dysfunctions, 19 (38%) were diagnosed with euthyroid sick syndrome, ten (20%) had overt hypothyroidism, three (6%) had subclinical hypothyroidism, and none of the patients had hyperthyroidism. Antithyroglobulin antibodies (Anti-TG) was normal in all patients of the studied group, and antithyroid peroxidase (anti-TPO) was elevated in one (2%) out of 50 patients. There was a significant negative correlation between free thyroxine (FT4) and disease duration with a p-value of 0.007. Moreover, by comparing the duration of the disease and thyroid antibodies (anti-TG, and anti-TPO), there was a significant negative correlation with p-values of 0.015 and 0.028. Conclusions Intermittent biochemical screening of thyroid function and anti-thyroid antibodies is recommended as part of the clinical profile in SLE patients, to identify clinical/subclinical thyroid disease. To intervene with the most convenient therapy whenever indicated.

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PReS-FINAL-2292: Hypogonadism and osteoporosis among adolescents with systemic lupus erythematosus

Cited by 2 publications

References 0 publications

Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility

Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility

Association between Systemic Lupus Erythematosus and Autoimmune Thyroid Dysfunction in Pediatric Population Cross Sectional Study, Single Center Experience

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