Prescribing pattern of drugs in patients with alcoholic liver disease in a tertiary care teaching hospital

Kolasani, Bhanu Prakash; Sasidharan, Prasanand; Cm, Divyashanthi; Jayabal, Pandiamunian; Rajaseharan, Annabelle

doi:10.5455/njppp.2017.7.1233027012017

Cited by 8 publications

(10 citation statements)

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“…A few efficient varieties of herbal preparation like Liv-52, silymarin (Kolasani et al, 2017) and Stronger neomycin phages (SNMC) are in attendance against hepatic complications. All the candidates come up with notable complications.…”

Section: Introductionmentioning

confidence: 99%

Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes

et al. 2019

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The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situation. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease, long term alcohol abuse and chronic use of medications can cause persistent injury in which regenerative capacity eventually becomes dysfunctional resulting in hepatic scaring and cirrhosis. Despite the recent therapeutic advances and significant development of modern medicine, hepatic diseases remain a health problem worldwide. Thus, the search for the new therapeutic agents to treat liver disease is still in demand. Many synthetic drugs have been demonstrated to be strong radical scavengers, but they are also carcinogenic and cause liver damage. Present day various hepatic problems are encountered with number of synthetic and plant based drugs. Nexavar (sorafenib) is a chemotherapeutic medication used to treat advanced renal cell carcinoma associated with several side effects. There are a few effective varieties of herbal preparation like Liv-52, silymarin and Stronger neomin phages (SNMC) against hepatic complications. Plants are the huge repository of bioactive secondary metabolites viz; phenol, flavonoid, alkaloid etc. In this review we will try to present exclusive study on phenolics with its mode of action mitigating liver associated complications. And also its future prospects as new drug lead.

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Section: Introductionmentioning

confidence: 99%

Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes

et al. 2019

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“…Aljarari et al reported that laxatives were prescribed in about 17.6% of the total number of prescriptions studied and that bisacodyl being the most frequently laxative prescribed (59.5%) followed by lactulose (40.5 %) [16]. Another study showed that regarding the drugs that were prescribed for patients with alcoholic liver disease, the most commonly prescribed drug for treating the complications like hepatic encephalopathy and variceal bleeding were lactulose (46.9%) and propranolol (80.7%) [17].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Lactulose Prescribing Pattern in Outpatient Setting

Ahmed

2021

JPRI

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Aim: This study aims to describe the prescribing pattern of lactulose in the outpatient setting of a public hospital. Methodology: This is a cross-sectional study that was conducted in Alkharj city. Prescription data were collected retrospectively from electronic medical records in the outpatient setting of the hospital. Results: A total of 113 patients received lactulose in the outpatient setting of the hospital. Most of them were males (66.37%). Approximately 24% of the patients aged between 30-39 years and about 20.35% of them aged between 20-29. Most of the patients received lactulose for 7 days (70.8%). Most of the prescriptions were written by the Emergency department (84.07%). Conclusion: Lactulose prescribing was uncommon in the present study. Nevertheless, it is important to use it appropriately to increase its efficacy and safety. The patient should take it as recommended, and the health care professionals should counsel patients about their medications.

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“…Patients over 50 yrs of age are at high risk of developing liver disease due to immunological and functional disturbances, there is a link between obesity and risk of liver disease Loomis K et al 13 32.4% patients with liver disease were alcoholic, 32.3% were nonalcoholic having NASH and Viral hepatitis. Partha S. Mukherjee et al 16 Kolasani et al 7 revealed in their study that alcoholism is associated with liver disease. Co morbidities like DM, HTN has association with liver diseases.…”

Section: Discussionmentioning

confidence: 97%

“…In addition, some drugs are used to treat the complications of ALD like antibiotics for infections; lactulose, rifaximin and L-ornithine L-aspartate (LOLA) for encephalopathy; furosemide and spironolactone for ascites and octreotide, propranolol and ethamsylate for variceal bleeding; disulfiram and naltrexone for decreasing the craving and dependence of alcohol; chlordiazepoxide for treating withdrawal symptoms The study of prescribing patterns seeks to monitor, evaluate and suggest modifications in practitioners prescribing habits so as to make medical care rational and cost-effective. 7 A Medline search of prescribing pattern of drugs in ALD has not shown any positive results. Hence, we planned this study to evaluate the prescribing pattern of drugs used in patients.…”

Section: Introductionmentioning

confidence: 98%

Study on Prescribing Patterns of Antimicrobial Agents In Liver Disease Patients

Priya

Kumar

Raj

et al. 2022

Int J Life Sci Pharm Res

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The present study aims at analyzing the prescribing patterns of antimicrobial agents in different liver diseases and to identify the drug-drug interactions among the prescribed drugs. A cross sectional observational study was conducted from February to July 2018. A total of 120 cases of patients receiving antimicrobials having different types of liver diseases were included. Statistical analysis shows that 80% of the popuation were male and 64% of the population was above the age of 50 years.. Liver disease like Liver Cirrhosis, Non alcoholic steato hepatitis, Viral hepatits, Jaundice, Hepatocellular carcinoma was found to be present among the study population, 50% of the population was overweight and 32% were alcoholic. Majority of them had ascites, abdominal distention and pedal edema as chief complaints and complications were hepatic encephalopathy and esophageal varices. The prescribed antimicrobial agents were antibiotics (95%) viz., Piptaz, rifaximin and taxim. antivirals (4%) such as entecavir and antifungals (1%) likeflucanazole. The drugs were prescribed according to the guidelines of the hospital. Mostly broad spectrum antibiotics were used in the management of liver disorders like Linezolid, Meropenem, Ertapenem, and Tobramycin. In severe cases combination of antimicrobials were given for effective therapy. Patient's transplantation was based on the MELD score, as the MELD score increases, the mortality rate also increases. MELD score =40 indicates mortality rate is >70%.

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Prescribing pattern of drugs in patients with alcoholic liver disease in a tertiary care teaching hospital

Cited by 8 publications

References 0 publications

Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes

Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes

Evaluation of Lactulose Prescribing Pattern in Outpatient Setting

Study on Prescribing Patterns of Antimicrobial Agents In Liver Disease Patients

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