Prescription drug use in pregnancy

Andrade, Susan E.; Gurwitz, Jerry H.; Davis, Robert L.; Chan, K. Arnold; Finkelstein, Jonathan A.; Fortman, Kristine K.; McPhillips, Heather; Raebel, Marsha A.; Roblin, Douglas W.; Smith, David H.; Yood, Marianne Ulcickas; Morse, Abraham N.; Platt, Richard

doi:10.1016/j.ajog.2004.04.025

Cited by 483 publications

(491 citation statements)

References 14 publications

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“…In contrast, the studies conducted in the USA and Nigeria revealed that less number of category A drugs were prescribed. 16,20 In this study, about 27% of drugs prescribed were FDA category B drugs. This finding is different from various studies which is relatively less compared to the observation made by various researches, 14,16,18 however, it is more than the finding of the study reported by other researcher.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] Inappropriate use of medications by pregnant women has been widely reported in different countries. [14][15][16] In Fitche Hospital there was no such study before for the safety and effectiveness of drug use during pregnancy. Hence, this study was carried out to evaluate the pattern of drug use and potential teratogenicity risk to fetus in women attending the antenatal clinic.…”

Section: Introductionmentioning

confidence: 99%

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Drug Utilization Pattern and Potential Teratogenicity Risk among Pregnant Women Visiting Antenatal Clinic: The Case of a Primary Hospital

Fikadu¹,

Kebebe²,

Amelo³

et al. 2015

IJOPP

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Background: Pregnancy is a special physiological condition where the treatment needs a special concern. Moreover, pharmacotherapy during pregnancy is very challenging since only a few medicines have been specifically tested for safety. Objective: The aim of this study was to evaluate the utilization pattern and the teratogenicity risk of the drugs prescribed to pregnant women in Fiche Hospital, Ethiopia. Methods: A retrospective study was conducted by reviewing medical case files of 323 pregnant women, encountered with at least one drug, out of 1876 pregnant women attending antenatal clinic from February 09/2013 to March 09/2014. The prescription pattern was assessed from perspectives of World Health Organization (WHO) core drug use indicators, and the United States Food and Drug Administration (FDA) fetal harm classification. Results: Among 1876 pregnant women who visited ANC clinic, a total of 323 women received 456 medications. The age of the patients was within the range of 16-49 years and the majority of them (77.22%) were within the age group of 20-35 years. The majority of pregnant women (80.47%) visited antenatal care (ANC) during their first trimester gestation. Out of the total drugs prescribed, category A drugs comprised 20.83%, category B (26.34%), category C (24.34%), category C/D (9.65%), category D (9.43%) and category X (1.09%). Percentage of encounter with antibiotics and injectable drugs were 31.8% and 19.30%, respectively. Conclusion: Approximately half of the pregnant women utilized drugs from FDA category C, D and X which are thought to cause fetal harm; therefore, the use of these drugs should be minimized.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drug Utilization Pattern and Potential Teratogenicity Risk among Pregnant Women Visiting Antenatal Clinic: The Case of a Primary Hospital

Fikadu¹,

Kebebe²,

Amelo³

et al. 2015

IJOPP

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show abstract

“…[6][7][8][9][10][11][12][13][14][15][16] Major differences in study design, study population, time period, drug exposure ascertainment method and drug classification systems (some used FDA system while others used European or Australian or 'ad hoc' system) make it difficult to reconcile rates observed in different studies. For studies used similar methodology, the results were quite similar to ours.…”

Section: Commentmentioning

confidence: 99%

“…For example, by linking three nationwide registration databases in Finland, Malm et al 10 found that 20.4% women used at least one prescription drug during pregnancy with potential fetal risk and 3.4% used at least one clearly harmful drug by FDA criterion. Andrade et al 7 reported that 1.1% of women received a category X drug after the initial prenatal care visit, and 3.3% of women received FDA category D or X during the pregnancy period, 8 using data from a Health Maintenance Organization. Olesen et al 15 found 0.9% of Danish pregnant women filled prescriptions for drugs associated with human malformations in a population-based study.…”

Section: Commentmentioning

confidence: 99%

Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population

et al. 2008

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Objective: To examine prescription Food and Drug Administration (FDA) C, D and X drugs in general obstetric population.Study Design: Historical cohort study.Result: A total of 18 575 women who gave a birth in Saskatchewan between January 1997 and December 2000 were included. Among them, 3604 (19.4%) received FDA C, D or X drugs at least once during pregnancy. The pregnancy exposure rates were 15.8, 5.2 and 3.9%, respectively, for category C, D and X drugs, and were 11.2, 7.3 and 8.2%, respectively, in the first, second and third trimesters. Salbutamol (albuterol), trimethoprim/sulfamethoxazole (co-trimoxazole), ibuprofen, naproxen and oral contraceptives were the most common C, D, X drugs used during pregnancy.Conclusion: About one in every five women uses FDA C, D and X drugs at least once during pregnancy, and the most common prescription drugs in pregnancy are antiasthmatic, antibiotics, nonsteroid anti-inflammation drugs, antianxiety or antidepressants and oral contraceptives.

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“…The frequency of codeine use during pregnancy has been shown to range between 1% and 3.5% [1][2][3]. Studies specifically targeting codeine safety during pregnancy are either small casecontrol studies or case reports with inherent methodological limitations that generally warrant cautious interpretation.…”

Section: Introductionmentioning

confidence: 99%

The effects of codeine on pregnancy outcome: Results from a large population-based cohort study

Nezvalová-Henriksen

Spigset

Nordeng

2011

Reproductive Toxicology

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Prescription drug use in pregnancy

Cited by 483 publications

References 14 publications

Drug Utilization Pattern and Potential Teratogenicity Risk among Pregnant Women Visiting Antenatal Clinic: The Case of a Primary Hospital

Drug Utilization Pattern and Potential Teratogenicity Risk among Pregnant Women Visiting Antenatal Clinic: The Case of a Primary Hospital

Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population

The effects of codeine on pregnancy outcome: Results from a large population-based cohort study

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