Prescription medication use during pregnancies that resulted in births and abortions (2001-2013): A retrospective population-based study in a Canadian population

Abstract

We aimed to describe medication use in pregnancies that resulted in births and abortions, as well as use after a pregnancy-related visit to characterize the receipt of medication after knowledge of pregnancy. Abortions included both spontaneous and induced abortions. Rates of medication use among women with a pregnancy outcome (2001–2013) were described using the Manitoba Population Research Data Repository at the Manitoba Centre for Health Policy. Use was determined as ≥ 1 prescription filled during pregnancies that resulted in births (livebirth/stillbirth) and abortions. Rates were calculated at any time during pregnancy and after a pregnancy-related visit. Rates were additionally characterized by risk in pregnancy using Briggs classification (2017). Of 174,848 birth pregnancies, overall 64.9% filled ≥ 1 prescription during pregnancy (a significant increase from 62.3% to 68.8% from 2001–2013, p<0.0001); 55.4% filled ≥ 1 prescription after a pregnancy-related visit. Of 71,967 abortions, 44.7% filled ≥ 1 prescription (a significant increase from 42.6% to 46.8% from 2001–2013, p<0.0001). Only 3.7% of birth pregnancies had at least one prescription for a contraindicated medication (according to Briggs classification), whereas 10.8% of abortions filled a prescription for a contraindicated medication. The most common drugs used in pregnancy were amoxicillin, doxylamine, codeine combinations, nitrofurantoin, cephalexin, salbutamol and ranitidine. Fewer women filled prescriptions for undesirable medications according to Briggs classification during pregnancy after a pregnancy-related visit.

Investigating the efficacy and safety of metronidazole during pregnancy; A systematic review and meta-analysis

“…Cohort 2829 250−500 7 Systemic 1 Bacterial vaginosis and trichomoniasis Preterm birth, low birth weight, malformations [ 43 ] Zagorodnikova et al 2017 Retrospec. Cohort 901 – – – 1,2,3 Genitourinary tract infections Malformations, spontaneous abortion [ 44 ] Leong et al 2019 Retrospec. Cohort 246,817 – – – – – Spontaneous abortion [ 45 ] Mann et al 2009 Retrospe.…”

“…Five observational studies [ 19 , 40 , 43 , 44 , 46 ] evaluated the association of spontaneous abortion and MET exposure ( Fig. 2 B).…”

Sentimentos De Mulheres Advindos Da Experiência Em Um Processo De Abortamento

“…Embora o comportamento durante a descoberta da gravidez seja provavelmente diferente em casos de abortamentos espontâneos e induzidos, acredita-se que a descoberta precoce da gravidez possa influenciar os abortamentos. Estudo demonstrou redução no uso de medicamentos durante a gravidez após as consultas, devido a maior percepção de danos possíveis ao feto ou da não necessidade do tratamento medicamentoso (14) . Estudo (15) relata que há um enorme conflito nas mulheres causado pela contradição de sentir-se felizes e tristes com a descoberta da gravidez.…”

ReproTox-KG: Toxicology Knowledge Graph for Structural Birth Defects

“…This multidisciplinary nature of reproductive health is challenging. For instance, prescribing drugs in pregnancy remains a complex and controversial issue for mothers and physicians [4]. A key challenge to prescribing for the gravid patient is that recommendations are based on limited human pharmacological data and conflicting cases of adverse outcomes, given that pregnant populations are routinely excluded from randomized controlled trials [5].…”