Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow

Wang, Lin; Li, Yan; Jiang, Jinling; Zhang, Yuyi; He, Qiyu; Zhang, Hui

doi:10.1080/22221751.2020.1761762

Cited by 8 publications

(6 citation statements)

References 15 publications

(16 reference statements)

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“…1 ). This is consistent with clinical observations that both GT3 and GT4 HEV patients have been reported from these regions [ [13] , [14] , [15] , [16] ]. Although Europe is dominated by GT3, GT4 HEV has been identified in some peculiar cases including chronically infected patients [ 17 ].…”

Section: Resultssupporting

confidence: 93%

Estimating the global prevalence of hepatitis E virus in swine and pork products

et al. 2022

One Health

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Zoonotic transmission of hepatitis E virus (HEV), in particular the genotype (GT) 3 and GT4 strains, constitutes a major one health issue. Swine serves as an important reservoir and the processed pork products essentially contribute to foodborne transmission. This study comprehensively estimated HEV prevalence in domestic pigs, wild boars, and pork products. At global level, we found nearly 60% domestic pigs and 27% wild boars have ever encountered HEV infection based seroprevalence rate. Nearly 13% domestic and 9.5% wild swine are actively infected based on HEV RNA positivity. Importantly, about 10% of commercial pork products are HEV RNA positive, although available data are limited in this respect. Our results indicate the high prevalence rate of HEV infection in pigs and widespread contamination in pork products, although there are substantial variations at regional and country levels. These findings are important for better understanding the global epidemiology and clinical burden of HEV infection in human population related to zoonotic transmission.

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Section: Resultssupporting

confidence: 93%

Estimating the global prevalence of hepatitis E virus in swine and pork products

et al. 2022

One Health

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“…These results corresponded to a recent study reported by Wang et al. ( 13 ). They demonstrated the presence and persistence of HEV RNA and Ag in human BM and BM tropism of HEV both G3 and G4.…”

Section: Case Presentationsupporting

confidence: 94%

Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient

et al. 2022

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Hepatitis E virus (HEV) is one of the most important public health issues around the world, and chronic HEV infection has been reported in immunosuppressed individuals. This study reported a male case, with very severe aplastic anemia (AA), who developed chronic hepatitis E after hematopoietic stem cell transplantation (HSCT). Abnormal alanine aminotransferase (ALT) appeared after HSCT and persisted for twenty-nine months. The case was seropositive for anti-HEV IgG and IgM after HSCT. Twenty-two months after HSCT, HEV RNA and antigen (Ag) testing were positive and persisted for five and seven months, respectively. Positive stains of HEV Ag were present in a liver biopsy sample. HEV Ag was present in bone marrow. The individual rapidly developed liver cirrhosis and was rescued by a regimen of oral ribavirin. These factors suggested there is a risk of HEV infection in HSCT recipients.

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“…Viral replication has also been demonstrated in the kidneys of infected rabbits by detection of both positive and negative strands of HEV RNA as well as by immunohistochemical analysis [ 14 ]. Besides, HEV has been isolated from neuronal cells [ 15 ], placenta [ 16 ], the bone marrow [ 17 ], and breast milk [ 18 ]. These findings challenge the dogma that HEV is an exclusively hepatotropic virus and suggest that renal manifestations of AHE may as well be a result of active extrahepatic viral replication.…”

Section: Discussionmentioning

confidence: 99%

Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A

et al. 2021

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In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L; p < 0.001 and 5.2 mg/dL; p < 0.001), suggesting a generally less severe hepatitis. In contrast, patients with AHE had significantly higher median serum creatinine levels (0.9 mg/dL vs. 0.8 mg/dL; p = 0.002) and lower median estimated glomerular filtration rate (eGFR) (91 mL/min/1.73 m2 vs. 109 mL/min/1.73 m2; p < 0.001) than patients with AHA. Leucocyte, neutrophil and lymphocyte count, hemoglobin, platelets, red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and RDW to lymphocyte ratio (RLR) did not differ between patients with AHE and those with AHA. Our observations indicate that renal but not hematological interference presents an underrecognized extrahepatic feature of AHE, while inflammation of the liver seems to be more severe in AHA.

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Presence and persistence of hepatitis E virus RNA and proteins in human bone marrow

Cited by 8 publications

References 15 publications

Estimating the global prevalence of hepatitis E virus in swine and pork products

Estimating the global prevalence of hepatitis E virus in swine and pork products

Case Report: Chronic hepatitis E in a hematopoietic stem cell transplant recipient: The first report of hepatitis E virus genotype 4 causing chronic infection in a non-solid organ recipient

Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A

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