Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody.

Khanna, Ashwani; Buskirk, Daniel R.; Williams, Ralph C.; Gibofsky, Allan; Crow, Mary K.; Menon, Arvind; Fotino, M; Reid, H M; Poon-King, Theo; Rubinstein, Pablo

doi:10.1172/jci114071

Cited by 158 publications

(81 citation statements)

References 12 publications

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“…Age at which exposure occurs also appears to affect the risk for Sydenham's chorea; children between the ages of 4 and 14 show the highest rate of this complication, and adult onset of Sydenham's chorea is unusual (16)(17)(18). The observation that rheumatic fever is more prevalent among relatives than unrelated comparison subjects supports the hypothesis that susceptibility to rheumatic fever is, in part, genetically determined (19)(20)(21). Substantial evidence indicates that patients with rheumatic fever have an abnormal humoral and cellular immunologic response to streptococcal antigens cross-reactive with mammalian tissues (22).…”

mentioning

confidence: 65%

B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

Murphy

Goodman²,

Fudge³

et al. 1997

AJP

161

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confidence: 65%

B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

Murphy

Goodman²,

Fudge³

et al. 1997

AJP

161

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“…The percentages of D8/17-positive cells were measured with immunofluorescence microscopy, as described. 17,38 A minimum of 200 anti-HLA-DR-positive peripheral blood mononuclear cells, representing B lymphocytes and monocytes, were counted after mounting with an antiquenching agent. Individual anti-HLA-DR-positive cells were scored for fluorescein labeling attributable to bound D8/17 monoclonal antibody plus anti-mouse immunoglobulin M conjugate; the percentages of anti-HLA-DR-positive cells that were also stained with the D8/17 monoclonal antibody were calculated.…”

Section: Antistreptococcal Titersmentioning

confidence: 99%

“…Patients with RF and their siblings have significantly greater proportions of D8/17-reactive cells, compared with control populations. [15][16][17] The percentages of anti-HLA-DR-staining cells that were immunoreactive with the D8/17 monoclonal antibody were compared for patients and control subjects at the baseline time point (Fig 1). The mean percentages of D8/17-positive cells were 19.3% and 13.1% for patients and control subjects, respectively; this difference was highly significant (2-sided t test, t ϭ 2.73, df ϭ 64, P ϭ .0029).…”

mentioning

confidence: 99%

“…On the basis of previous studies of RF, TS, and OCD patients, [15][16][17][18][19][20][21][22] we also measured the levels of peripheral blood B lymphocytes expressing the D8/17 surface antigen at baseline, at exacerbation, and 2 months after neuropsychiatric symptom exacerbation. Nonspecific markers of acute inflammation, ie, neopterin and C-reactive protein (CRP), were also measured at those 3 time points.…”

mentioning

confidence: 99%

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Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections

Luo¹,

et al. 2004

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ABSTRACT. Background. It has been proposed that infection by group A ␤-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms.Objective. To examine the temporal relationship between newly acquired GABHS infections (and other immunologic indices) and acute exacerbations of tics and obsessive-compulsive symptoms.Methods. Pediatric patients (7-17 years of age) with TS and/or OCD (N ‫؍‬ 47) and healthy control subjects (N ‫؍‬ 19) were prospectively monitored for newly acquired GABHS infections, nonspecific markers of acute inflammatory responses, and D8/17-reactive cells (a marker of rheumatic fever). Objective monthly ratings of tic and obsessive-compulsive symptom severity were used to determine the timing of symptom exacerbations.Results. The overall rate of acute exacerbations of neuropsychiatric symptoms was 0.56 exacerbations per patient per year. The average rate of new GABHS infections, using a stringent definition, was 0.42 infections per subject per year among patients, compared with 0.28 infections per subject per year for control subjects. The association between symptom exacerbations and new GABHS infections among patients was no greater than that expected on the basis of chance. At baseline, patients demonstrated significantly higher levels of D8/17-reactive cells and neopterin, compared with control subjects, but there was no consistent pattern of change when exacerbation time points were compared with baseline or follow-up time points.Conclusions. The results suggest no clear relationship between new GABHS infections and symptom exacerbations in an unselected group of patients with TS and/or OCD. Pediatrics 2004;113:e578 -e585. URL: http://www. pediatrics.org/cgi/content/full/113/6/e578; Tourette's syndrome, obsessive-compulsive disorder, PANDAS, group A ␤-hemolytic streptococci, D8/17, neopterin, C-reactive protein.ABBREVIATIONS. ADHD, attention-deficit/hyperactivity disorder; ASO, anti-streptolysin O; BRR, B repeat region; CRP, C-reactive protein; CRR, C repeat region; Y-BOCS, Yale-Brown Obsessive-Compulsive Scale; GABHS, group A ␤-hemolytic streptococci; OCD, obsessive-compulsive disorder; OC, obsessive compulsive; PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections; RF, rheumatic fever; TS, Tourette's syndrome; YGTSS, Yale Global Tic Severity Scale; IgG, immunoglobulin G.T ic disorders, obsessive-compulsive disorder (OCD), and related conditions affect as many as 3% of children and adolescents. [1][2][3][4][5][6] The factors that contribute to the pathogenesis of these disorders are poorly defined. The hypothesis that infections can modulate the clinical appearance of tic disorders dates from the 1800s. 7 The past decade has seen the reemergence of the hypothesis that postinfectious immune mechanisms account for at least some cases of Tourette's syndrome (TS) and OCD.It is well known that group A ␤-hemolytic streptococci (GABHS...

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“…Para estudar essa hipótese, os níveis de LB marcados com D8/17 foram analisados em pacientes com glomerulonefrite difusa aguda (GNDA), ou seja, pacientes que desenvolveram uma grande reatividade ao SBHGA (formação de imunocomplexos) mas que não produziram anticorpos ou resposta citotóxica contra tecidos do próprio organismo como ocorre na FR. Nesses pacientes ou seus familiares não foram encontrados valores aumentados de D8/17 mesmo que neles os níveis de anticorpos antiestreptocóccicos estivessem elevados 7,10 . Além disso, os valores de LB marcados com D8/17 mantêm-se estáveis por muito tempo mesmo na ausência de novas infecções (Zabriskie, comunicação pessoal, 1999).…”

Section: D8/17 Na População Normal Na Fr E Em Outras Doenças Autoimunesunclassified

Marcador D8-17: implicações para a neuropsiquiatria

Diniz¹,

Alvarenga²,

Hounie³

et al. 2000

Arq. Neuro-Psiquiatr.

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RESUMO -Estudos recentes sugerem uma associação entre febre reumática (FR) e transtornos do espectro obsessivo-compulsivo, o que levou à hipótese de que alterações na resposta imune pudessem ter um papel na etiologia destes últimos. Um marcador biológico que talvez identifique maior susceptibilidade para o desenvolvimento de FR e desses transtornos neuropsiquiátricos tem causado grande interesse na literatura. Tratase do D8/17, um anticorpo monoclonal contra um antígeno de membrana de linfócitos B. Neste artigo introduzimos conhecimentos sobre o D8/17 e discutimos suas implicações como um possível marcador biológico de transtornos neuropsiquiátricos associados ou não à FR.PALAVRAS-CHAVE: febre reumática, coréia de Sydeham, transtorno obsessivo-compulsivo, síndrome de Tourrete, D8/17. D8/17 marker: implication to neuropsychiatryABSTRACT -Recent studies suggest that there is a relationship between rheumatic fever (RF) and some neuropsychiatric disorders. Thus, it has been thought that autoimmune mechanisms might be related to the etiology of these neuropsychiatric disorders. It has also been demonstrated that a B cell alloantigen associated to RF is also abnormally overexpressed in patients with such neuropsychiatric disorders. This alloantigen is recognised by a monoclonal antibody known as D8/17. The aim of this article is to introduce the recent work done about D8/17 and its possible implications to the study of neuropsychiatric disorders related or not to RF.KEY WORDS: rheumatic fever, Sydeham chorea, obsessive-compulsive disorder, Tourrete syndrome, D8/17. Na ausência de conhecimentos sobre a etiologia da maior parte dos transtornos neuropsiquiátricos e de exames laboratoriais diagnósticos, o marcador D8/17, aparece como instrumento de grande valor heurístico para a prática clínica. Nos próximos parágrafos apresentamos os conceitos sobre o D8/17 e discutimos suas possíveis implicações como possível marcador biológico de alguns transtornos neuropsiquiátricos associados ou não à febre reumática (FR).Acredita-se que a FR, uma sequela da faringite causada por um estreptococco beta hemolítico do grupo A (SBHGA), possua etiologia auto imune, possivelmente associada a um mimetismo

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Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody.

Cited by 158 publications

References 12 publications

B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

Prospective Longitudinal Study of Children With Tic Disorders and/or Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Newly Acquired Streptococcal Infections

Marcador D8-17: implicações para a neuropsiquiatria

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