Presence of spirochaetes in paresis despite penicillin therapy.

Gager, W E; Israel, C W; Smith, James O.

doi:10.1136/sti.44.4.277

Cited by 9 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The possibility of reinfection exists, although none of the patients showed evidence of it. There are reports that living spirochetes have been isolated from patients after treatment with the recommended doses of penicillin (Gager et al 1968, Yoder 1975, Tramont 1976). Ritter et al (1975) studied the concentration of penicillin in the CSF after intramuscular and intravenous injections in patients with neurosyphilis and found that the treponemastatic level was only reached in a very short period after the injection of 4 M.U.…”

Section: Discussionmentioning

confidence: 99%

The incidence and clinical presentation of neurosyphilis in Greater Copenhagen 1974 through 1978

Nordenbo

Sørensen

2009

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

The incidence of neurosyphilis in the Greater Copenhagen region was found to be 0.30 per 100,000 inhabitants per year within a 5 year period. This figure is higher than incidence found in other studies from the last decades, but does not represent a statistically significant rise. Using hospital records from relevant departments 23 patients were described. General paresis and meningovascular cases were the most common manifestations. A tendency towards a changing clinical pattern of neurosyphilis was confirmed. Dementia and personality changes were the most frequently observed clinical symptoms. The classical signs of tabes dorsalis were seen in only very few patients. Stroke was a common manifestation. We recommend Standard Serological Tests for Syphilis to be carried out in patients under 60 years of age with cerebrovascular diseases, dementia and in patients where neurosyphilis could be even a remote diagnostic possibility.

show abstract

Section: Discussionmentioning

confidence: 99%

The incidence and clinical presentation of neurosyphilis in Greater Copenhagen 1974 through 1978

Nordenbo

Sørensen

2009

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…The development of Charcot's arthropathy was confined to men. Banks (1968) (Hahn and others, 1959 Since publication of the work of Collart, Borel, andDurel (1962a, b, c, 1964) (Collart, Borel, andDurel, 1962a, b, c, 1964;Smith and Israel, 1968;Gager, Israel, and Smith, 1968). None the less it seems reasonable to raise the possibility that persistence of viable treponemes after treatment may account for the downhill course in certain cases of GPI.…”

Section: Discussionmentioning

confidence: 99%

“…The identity of these treponemal forms, the criteria for judging them Treponema pallidum and the evidence for their continuing virulence are still under debate (Turner, Hardy, and Newman, 1969); furthermore the number of cases of neurosyphilis in which treponemal forms have been found in tissue and CSF is small (Collart, Borel, andDurel, 1962a, b, c, 1964;Smith and Israel, 1968;Gager, Israel, and Smith, 1968). None the less it seems reasonable to raise the possibility that persistence of viable treponemes after treatment may account for the downhill course in certain cases of GPI.…”

Section: Discussionmentioning

confidence: 99%

Review of hospitalized cases of general paralysis of the insane.

Dawson-Butterworth¹,

Heathcote²

1970

Sexually Transmitted Infections

View full text Add to dashboard Cite

“…33,34 Perivascular and intracellular, phagocytosed, iron deposition constitutes a pathognomonic finding. 35 The identification of treponemes in the cerebral cortex of patients with general paresis has been reported. [35][36][37] Tabes dorsalis features demyelination, axonal degeneration, and atrophy of the posterior columns in the spinal cord.…”

Section: Pathologymentioning

confidence: 99%

Neurosyphilis

2019

View full text Add to dashboard Cite

Neurosyphilis is caused by the bacterium Treponema pallidum subspecies pallidum (T. pallidum). The organism gains entry into the central nervous system (CNS) early (primary syphilis or chancre phase) in the course of infection. While most patients are able to mount an immune response that effectively clears CNS invasion without long-term complications, a minority go on to develop asymptomatic or symptomatic neurosyphilis. Neurosyphilis has been divided into early and late stages. The early stages include asymptomatic meningitis, symptomatic meningitis, gumma, and meningovascular syphilis, while the late stages include dementia paralytica and tabes dorsalis. Ocular and otologic syphilis can occur at any time but often accompany the acute meningitis of early neurosyphilis. The diagnosis of symptomatic neurosyphilis requires meeting clinical, serologic, and cerebrospinal fluid (CSF) criteria, while the diagnosis of asymptomatic neurosyphilis relies on serologic and CSF criteria alone. In the last several decades, a persistent rise in syphilitic meningitis and other forms of early neurosyphilis have been seen in the human immunodeficiency virus-positive population, principally in men who have sex with men. This article reviews the clinical presentation, diagnosis, and treatment of neurosyphilis, and it addresses the controversy regarding the role of lumbar puncture early in the course of infection.

show abstract

Presence of spirochaetes in paresis despite penicillin therapy.

Cited by 9 publications

References 2 publications

The incidence and clinical presentation of neurosyphilis in Greater Copenhagen 1974 through 1978

The incidence and clinical presentation of neurosyphilis in Greater Copenhagen 1974 through 1978

Review of hospitalized cases of general paralysis of the insane.

Neurosyphilis

Contact Info

Product

Resources

About