Presence of vitamin D<sub>3</sub> receptor (VDR)‐like proteins in <i>Solanum glaucophyllum</i>

Milanesi, Lorena Magdalena; Boland, Ricardo

doi:10.1111/j.1399-3054.2006.00742.x

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…In fact, before the genome era the same situation was found for NR and many reports claimed for the detection of steroid receptors in a wide variety of non-metazoans organisms such as plants or fungi (see Agarwal et al, 1994, Milanesi et al, 2001, Milanesi and Boland, 2006. Despite the fact that, as in the above mentioned studies, all the controls were correct, all these studies displayed artefacts: there is no gene related to steroid receptors outside metazoans (Escriva et al, 1997, Escriva et al, 2004.…”

Section: Detectionmentioning

confidence: 63%

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

Markov

Paris

Bertrand

et al. 2008

Molecular and Cellular Endocrinology

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The evolution of the ligand/receptor couple: a long road from comparative endocrinology to comparative genomics. Molecular and Cellular Endocrinology, Elsevier, 2008, 293 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 32A c c e p t e d M a n u s c r i p t

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Section: Detectionmentioning

confidence: 63%

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

Markov

Paris

Bertrand

et al. 2008

Molecular and Cellular Endocrinology

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“…Neither VDR nor vitamin D-binding protein have yet been found in plants [ 16 ], but a VDR-like binding protein for 1,25(OH) 2 D 3 has been described in Solanum glaucophyllum (waxy leaf nightshade), suggesting that similar mechanisms of action may be present in plants [ 17 ]. The enzymes involved in the two hydroxylation reactions (25-hydroxylase and 25-hydroxyvitamin D 1α-hydroxylase), along with 25(OH)D 3 and 1,25(OH) 2 D 3 , in both free and glycosidic forms, have been identified in the leaves of Solanum malacoxylon [ 18 ] and Cestrum diurnum [ 19 ], plants known to be responsible for calcinosis in animals.…”

Section: Metabolism Of Vitamin D In Plantsmentioning

confidence: 99%

In Pursuit of Vitamin D in Plants

et al. 2017

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Vitamin D deficiency is a global concern. Much research has concentrated on the endogenous synthesis of vitamin D in human skin following exposure to ultraviolet-B radiation (UV-B, 280–315 nm). In many regions of the world there is insufficient UV-B radiation during winter months for adequate vitamin D production, and even when there is sufficient UV-B radiation, lifestyles and concerns about the risks of sun exposure may lead to insufficient exposure and to vitamin D deficiency. In these situations, dietary intake of vitamin D from foods or supplements is important for maintaining optimal vitamin D status. Some foods, such as fatty fish and fish liver oils, certain meats, eggs, mushrooms, dairy, and fortified foods, can provide significant amounts of vitamin D when considered cumulatively across the diet. However, little research has focussed on assessing edible plant foods for potential vitamin D content. The biosynthesis of vitamin D in animals, fungi and yeasts is well established; it is less well known that vitamin D is also biosynthesised in plants. Research dates back to the early 1900s, beginning with in vivo experiments showing the anti-rachitic activity of plants consumed by animals with induced rickets, and in vitro experiments using analytical methods with limited sensitivity. The most sensitive, specific and reliable method for measuring vitamin D and its metabolites is by liquid chromatography tandem mass spectrometry (LC-MS/MS). These assays have only recently been customised to allow measurement in foods, including plant materials. This commentary focuses on the current knowledge and research gaps around vitamin D in plants, and the potential of edible plants as an additional source of vitamin D for humans.

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“…On the basis of cladistic analysis the presence of these compounds was predicted to be a characteristic of Angiosperms [149]. [151].…”

Section: Figure 24mentioning

confidence: 99%

Toxic Chemical Compounds of the Solanaceae

Pomilio

Falzoni

Vitale

2008

Natural Product Communications

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The Solanaceae is comprised of some 2500 species of cosmopolitan plants, especially native to the American continent. They have great value as food, like the well-known potato, tomato and eggplants, and medicines, like species of Atropa, Withania and Physalis, but many plants of this family are toxic, and sometimes lethal to mammals, in particular to man. Some of them also produce hallucinations and perceptual changes. The toxic species of this family are characterized by the occurrence of a variety of chemical compounds, some of which are responsible for the toxicity and lethality observed after ingestion, while others are suspected to be toxic. In this review, the following toxic compounds belonging to different members of the Solanaceae family are described: Tropane alkaloids (Atropa, Datura, Hyoscyamus, Mandragora); pyrrolidine and pyrrolic alkaloids (Nierembergia, Physalis, Solanum); protoalkaloids (Nierembergia); glycoalkaloids (Lycopersicon, Solanum); nicotine (Nicotiana); cardenolides (Cestrum, Nierembergia); capsaicinoids (Capsicum); kaurene-type tetracyclic diterpenes (Cestrum); steroidal glycosides (Cestrum, Solanum); 1,25-dihydroxyvitamin D 3 and vitamin D 3 (Cestrum, Solanum, Nierembergia); and withasteroids, withanolides (Withania), and physalins (Physalis). Other bioactive chemical constituents of members of this family are sugar esters and lectins. Phenylpropanoids are not included in this paper.

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Presence of vitamin D₃ receptor (VDR)‐like proteins in Solanum glaucophyllum

Abstract: The detection of 1a,25(OH) 25(OH)

Cited by 7 publications

References 39 publications

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

In Pursuit of Vitamin D in Plants

Toxic Chemical Compounds of the Solanaceae

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Presence of vitamin D3 receptor (VDR)‐like proteins in Solanum glaucophyllum

Abstract: The detection of 1a,25(OH) 25(OH)

Cited by 7 publications

References 39 publications

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics

In Pursuit of Vitamin D in Plants

Toxic Chemical Compounds of the Solanaceae

Contact Info

Product

Resources

About

Presence of vitamin D₃ receptor (VDR)‐like proteins in Solanum glaucophyllum