2022
DOI: 10.1016/bs.ircmb.2022.04.008
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Present and future of lipid nanoparticle-mRNA technology in phenylketonuria disease treatment

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Cited by 5 publications
(4 citation statements)
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“…LNP research in tumor immunotherapy will also focus more on safety and on the management of side effects. With the promotion of LNPs in clinical applications, it is necessary to have more in-depth understandings of their metabolic dynamics and toxic reactions in the body, of engaging in the timely detection and remediation of potential safety risks, and of ensuring the safety and controllability of the treatment [ 219 , 220 , 221 , 222 ]. In addition, in the future, LNP carriers may be combined with emerging technologies, such as nanotechnology and gene editing, in order to explore a variety of new therapeutic strategies [ 223 , 224 , 225 , 226 ].…”
Section: Future Prospects and Challengesmentioning
confidence: 99%
“…LNP research in tumor immunotherapy will also focus more on safety and on the management of side effects. With the promotion of LNPs in clinical applications, it is necessary to have more in-depth understandings of their metabolic dynamics and toxic reactions in the body, of engaging in the timely detection and remediation of potential safety risks, and of ensuring the safety and controllability of the treatment [ 219 , 220 , 221 , 222 ]. In addition, in the future, LNP carriers may be combined with emerging technologies, such as nanotechnology and gene editing, in order to explore a variety of new therapeutic strategies [ 223 , 224 , 225 , 226 ].…”
Section: Future Prospects and Challengesmentioning
confidence: 99%
“…This brain malfunction leads to significant intellectual impairment, epilepsy, and behavioral issues if left untreated (1) . In PKU body's inability to eliminate excessive phenylalanine can cause growth retardation and catastrophic brain abnormalities (2) . Phenylketonuria (PKU) is caused by one or more inborn mutations in the phenylalanine hydroxylase gene.…”
Section: Phenylketonuriamentioning
confidence: 99%
“…-Anxiety scale (2,4,7,9,15,19,20) evaluates situational anxiety, the effect of anxiety on autonomic stimulation and muscles as well as personal sleileb about the effect of anxiety.…”
Section: Operational Definitionmentioning
confidence: 99%
“…LNP research in tumor immunotherapy will also focus more on safety and the management of side effects. With the promotion of LNPs in clinical applications, it is necessary to have a more in-depth understanding of their metabolic dynamics and toxic reactions in the body, the ability to engage in timely detection and remediation of potential safety risks, and be able to ensure the safety and controllability of the treatment [219][220][221][222] . In addition, LNP vectors may be combined with emerging technologies such as nanotechnology and gene editing in the future to explore a variety of new therapeutic strategies [223][224][225][226] .…”
Section: Future Prospects and Challengesmentioning
confidence: 99%