Abstract. The Alpine mountains in central Europe are characterized by a heterogeneous crust accumulating different tectonic units and blocks in close proximity to sedimentary foreland basins. Centroid moment tensor inversion provides insight into the faulting mechanisms of earthquakes and related tectonic processes, but is significantly aggravated in such an environment. Thanks to the dense AlpArray seismic network and our flexible bootstrap-based inversion tool Grond we are able to test different set-ups with respect to the uncertainties of the obtained moment tensors and centroid locations. We evaluate the influence of frequency bands, azimuthal gaps, input data types and distance ranges and study the occurrence and reliability of non-DC components. We infer that for most earthquakes (Mw ≥ 3.3) a combination of time domain full waveforms and frequency domain amplitude spectra in a frequency band of 0.02–0.07 Hz is suitable. Relying on the results of our methodological tests, we perform deviatoric MT inversions for events with Mw > 3.0. We present here 75 solutions and analyse our results in the seismo-tectonic context of historic earthquakes, seismic activity of the last three decades and GNSS deformation data. We study regions of high seismic activity, namely the western Alps, the region around Lake Garda, the SE Alps, besides clusters further from the study region, in the northern Dinarides and the Apennines. Seismicity is particularly low in the eastern Alps and in parts of the central Alps. We apply a clustering algorithm to focal mechanisms, considering additional focal mechanisms from existing catalogs. Related to the NS compressional regime, E-W to ENE-WSW striking thrust faulting is mainly observed in the Friuli area in the SE Alps. Strike-slip faulting with a similarly oriented pressure axis is observed along the northern margin of the central Alps and in the northern Dinarides. NW-SE striking normal faulting is observed in the NW Alps showing a similar strike direction as normal faulting earthquakes in the Apennines. Both, our centroid depths as well as hypocentral depths in existing catalogs indicate that Alpine seismicity is predominantly very shallow; about 80 % of the studied events have depths shallower than 10 km.