Present Knowledge of the Rhinovirus Group of Viruses

Mr, Hilleman

doi:10.1007/978-3-642-46062-3_1

Cited by 4 publications

(1 citation statement)

References 66 publications

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“…Genotyping. HRVs were originally characterized by their growth patterns in human embryonic and monkey kidney cells (222,223). However, this system demonstrated limited use, since growth characteristics changed with time in vitro (224).…”

Section: Molecular Methodsmentioning

confidence: 99%

Human Rhinoviruses

et al. 2013

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SUMMARYHuman rhinoviruses (HRVs), first discovered in the 1950s, are responsible for more than one-half of cold-like illnesses and cost billions of dollars annually in medical visits and missed days of work. Advances in molecular methods have enhanced our understanding of the genomic structure of HRV and have led to the characterization of three genetically distinct HRV groups, designated groups A, B, and C, within the genusEnterovirusand the familyPicornaviridae. HRVs are traditionally associated with upper respiratory tract infection, otitis media, and sinusitis. In recent years, the increasing implementation of PCR assays for respiratory virus detection in clinical laboratories has facilitated the recognition of HRV as a lower respiratory tract pathogen, particularly in patients with asthma, infants, elderly patients, and immunocompromised hosts. Cultured isolates of HRV remain important for studies of viral characteristics and disease pathogenesis. Indeed, whether the clinical manifestations of HRV are related directly to viral pathogenicity or secondary to the host immune response is the subject of ongoing research. There are currently no approved antiviral therapies for HRVs, and treatment remains primarily supportive. This review provides a comprehensive, up-to-date assessment of the basic virology, pathogenesis, clinical epidemiology, and laboratory features of and treatment and prevention strategies for HRVs.

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Section: Molecular Methodsmentioning

confidence: 99%