Present status of hormonal contraception (COCs)

Elstein, Max

doi:10.1007/bf01849658

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…In addition, conversion of oestrogens to androgens by aromatase, or transformation of weak androgens to more potent ones, occurs in extraglandular sites including the skin, hair follicles and sebaceous glands 18 . In women with underlying abnormalities of androgen metabolism, these features are amplified, and may be accompanied by other androgenic effects, such as irregular menstruation and hirsutism 2,4 . Oral contraceptives are a logical prophylaxis and treatment choice in such women.…”

Section: Discussionmentioning

confidence: 99%

“…Ethinyloestradiol at a dose of 0.03 mg is associated with a much lower incidence of serious cardiovascular adverse events than older formulations containing 50 µg. '• 2 However, with low-dose oestrogen combined oral contraceptives, the adverse events of the progestogen component become apparent.…”

mentioning

confidence: 99%

“…Dienogcst also has a relatively short plas1ila half-life, so does not accumulate with daily administration. "•' 2 Dienogest has weak binding affinity for androgen receptors. However, since it does not bind to sex hormone-binding globulin (SHBG), plasma levels arc high and sufficient to compete for receptors with native androgens.…”

mentioning

confidence: 99%

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The Effects of Valette® on Skin and Hair: A Post‐marketing Surveillance Study

Zimmermann

Wisser

Dietrich

2000

Int J Clinical Practice

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SUMMARYThe effects of Valette® ‐ an oral contraceptive containing ethinyloestradiol 0.03 mg and the antiandrogenic progestogen dienogest 2.0 mg ‐ on the skin and hair were surveyed over 63,474 cycles in 10,718 women in routine gynaecological practice. Improvements were greatest in women with severe or moderate androgen‐related symptoms. After six cycles, <1% of women had severely greasy hair and 6% had moderate greasiness, compared with 11 % and 27% at baseline; fewer hair washes were needed per week. The incidence of severe and moderately greasy skin disorders fell from 16% to <1%, and from 39% to 7.5%, respectively. Self‐assessments indicated less greasy hair and improved greasy skin disorders in 70% and 81% of women, respectively. The overall effect of Valette on the skin and hair was rated very good or good by 87.5% of women. These results confirm previous observations of a beneficial effect of Valette on androgen‐related skin and hair conditions. (Int J Clin Pract 2000; 54(2): 85‐91)

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%