Present Status of Radioactive Gold Therapy in Management of Prostatic Cancer

An evaluation of surgical treatment for spinal cord compression due to metastatic carcinoma

“…The remission of complete paraplegia presumed to be caused by prostatic metastases has been reported following the administration of oestrogens (Edelman, 1949), and more recently after adrenalectomy (Bowers, 1962). In addition, prostatic carcinoma is frequently radiosensitive (Rusche and Jaffe, 1958;Flocks, Culp, and Elkins, 1959), and the two patients with the best results in this series received a course of radiotherapy to the site of the spinal lesion following operation.…”

Biomarker distribution after injection into the canine prostate: implications for gene therapy

“…[20] used a dog model to determine the most effective means of delivering an adenovirus vector recombinant for β‐galactosidase to the prostate, and found that intraprostatic injection was more efficient than intravenous or intra‐arterial infusions. Several investigators have examined the transport of vital dyes, contrast material and radioisotopes after intraprostatic injection, to delineate the lymphatic drainage of the prostate [21–24]. Smith [22] showed that a vital dye injected into the prostate of both humans and dogs tracked in tissue planes towards the capsule.…”

Newer Developments in the Management of Prostatic Carcinoma*

“…However, in contrast, the writer and his associates (4) found that such removal followed by irradiation of the lymphatic bed with a solution of radioactive gold gave good results; 4 of 32 patients were living and without clinical evidence of cancer more than ten years after therapy, and 7 of 12 were living and well seven years after therapy. More recent experiences indicate that the latter figure is more nearly the correct one and that combination therapy in these cases offers real promise in appropriate cases (Figs.…”

“…By analogy, this result might be achieved in the pelvic area by instillation of colloidal Au 198 following lymphadenectomy, with the possibility of destroying remaining cells in lymph vessels not completely removed (see text). (Flocks et al (4). )…”

“…Distribution was fairly good, but rather poor about the nodule marked “X.” Such an area can be cauterized with high‐frequency electric current and the remaining tumor can be destroyed by the combined gamma and beta emissions of Au 198 which, in this case, had been injected as part of a program for combined therapy. (Flocks et al (4). )…”