Present Uses of and Experiences with Swine Vaccines

Bäckström, L

doi:10.1016/s0065-3519(99)80032-9

Cited by 11 publications

(9 citation statements)

References 1 publication

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“…However, A. pleuropneumoniae has been divided into 15 serotypes (4), with the lack of cross-protection between the main serotypes (5, 6) resulting in slow progress in the development of vaccines. To date, many studies have been reported and several vaccines have been commercialized, but complete satisfaction has not been obtained in the protection of pigs against A. pleuropneumoniae infection (7,8). Therefore, the development of new vaccines is urgently required.…”

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confidence: 99%

Specific Humoral Immune Response Induced by Propionibacterium acnes Can Prevent Actinobacillus pleuropneumoniae Infection in Mice

Yang

Lei

et al. 2014

Clin. Vaccine Immunol.

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bPorcine contagious pleuropneumonia, caused by Actinobacillus pleuropneumoniae, has a major impact on economics, ecology, and animal welfare in the pig-rearing industry. Propionibacterium acnes, a facultative anaerobic Gram-positive corynebacterium, exists widely in normal healthy adult animals. We have shown previously that P. acnes can prevent A. pleuropneumoniae infections in mice and pigs. To elucidate the mechanism of this effect and to identify novel A. pleuropneumoniae vaccines, the role of anti-P. acnes antibodies in preventing infection was analyzed by indirect immunofluorescence and opsonophagocytosis assays in vitro. The role of the specific humoral immune response induced by P. acnes was confirmed in a B cell depletion mouse model. The survival rates of mice challenged with A. pleuropneumoniae exhibited a highly significant positive rank correlation with the levels of anti-P. acnes antibodies. The specific antibodies induced by P. acnes had the ability to combine with A. pleuropneumoniae and increase opsonization of A. pleuropneumoniae for phagocytosis. Furthermore, analysis in the murine B cell depletion model confirmed that the humoral immune response induced by P. acnes played an important role in resistance to A. pleuropneumoniae infection. In this study, we further elucidated the reasons that P. acnes can prevent A. pleuropneumoniae infection, which provides useful evidence for the development of heterologous vaccines for the control of porcine contagious pleuropneumonia.

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confidence: 99%

Specific Humoral Immune Response Induced by Propionibacterium acnes Can Prevent Actinobacillus pleuropneumoniae Infection in Mice

Yang

Lei

et al. 2014

Clin. Vaccine Immunol.

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“…B. bronchiseptica is also a contributory agent in the porcine respiratory disease complex, a multifactorial disease state that is increasingly problematic for swine producers (2). However, vaccine efficacy is reported to be low, and atrophic rhinitis remains an important disease problem in grower/finisher pigs (1,34).…”

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confidence: 99%

Subcutaneous Vaccination with Attenuated Salmonella enterica Serovar Choleraesuis C500 Expressing Recombinant Filamentous Hemagglutinin and Pertactin Antigens Protects Mice against Fatal Infections with both S. enterica Serovar Choleraesuis and Bordetella bronchiseptica

Zhao

Xue

et al. 2008

Infect Immun

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“…Despite widespread use of B. bronchiseptica vaccines by swine producers throughout the world, respiratory disease associated with this agent remains a significant problem for the industry (5,54). The development of vaccines with improved efficacy is hindered by the absence of definitive data related to virulence mechanisms of B. bronchiseptica in swine.…”

Section: Discussionmentioning

confidence: 99%

“…Despite vaccination rates of up to 42%, only 10.5% of swine herds in the United States are free from atrophic rhinitis (54). A more recent study indicates that although B. bronchiseptica vaccines continue to be widely utilized by swine producers in both the United States and Europe, their effectiveness is questionable (5). B. bronchiseptica is also one of the agents involved in porcine respiratory disease complex, a multifactorial disease state that has been of increasing concern to swine producers since the early 1990s (7).…”

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Reduced Virulence of aBordetella bronchisepticaSiderophore Mutant in Neonatal Swine

Ducey

Brockmeier

et al. 2001

Infect Immun

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One means by which Bordetella bronchiseptica scavenges iron is through production of the siderophore alcaligin. A nonrevertible alcaligin mutant derived from the virulent strain 4609, designated DBB25, was constructed by insertion of a kanamycin resistance gene into alcA, one of the genes essential for alcaligin biosynthesis. The virulence of the alcA mutant in colostrum-deprived, caesarean-delivered piglets was compared with that of the parent strain in two experiments. At 1 week of age, piglets were inoculated with phosphate-buffered saline, 4609, or DBB25. Two piglets in each group were euthanatized on day 10 postinfection. The remainder were euthanatized at 21 days postinfection. Clinical signs, including fever, coughing, and sneezing, were present in both groups. Nasal washes performed 7, 14, and 21 days postinoculation demonstrated that strain DBB25 colonized the nasal cavity but did so at levels that were significantly less than those achieved by strain 4609. Analysis of colonization based on the number of CFU per gram of tissue recovered from the turbinate, trachea, and lung also demonstrated significant differences between DBB25 and 4609, at both day 10 and day 21 postinfection. Mild to moderate turbinate atrophy was apparent in pigs inoculated with strain 4609, while turbinates of those infected with strain DBB25 developed no or mild atrophy. We conclude from these results that siderophore production by B. bronchiseptica is not essential for colonization of swine but is required for maximal virulence. B. bronchiseptica mutants with nonrevertible defects in genes required for alcaligin synthesis may be candidates for evaluation as attenuated, live vaccine strains in conventionally reared pigs.

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Present Uses of and Experiences with Swine Vaccines

Cited by 11 publications

References 1 publication

Specific Humoral Immune Response Induced by Propionibacterium acnes Can Prevent Actinobacillus pleuropneumoniae Infection in Mice

Specific Humoral Immune Response Induced by Propionibacterium acnes Can Prevent Actinobacillus pleuropneumoniae Infection in Mice

Subcutaneous Vaccination with Attenuated Salmonella enterica Serovar Choleraesuis C500 Expressing Recombinant Filamentous Hemagglutinin and Pertactin Antigens Protects Mice against Fatal Infections with both S. enterica Serovar Choleraesuis and Bordetella bronchiseptica

Reduced Virulence of aBordetella bronchisepticaSiderophore Mutant in Neonatal Swine

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