Presentation of Celiac Disease in Finnish Children Is No Longer Changing: A 50-Year Perspective

Kivelä, Laura; Kaukinen, Katri; Lähdeaho, Marja–Leena; Huhtala, Heini; Ashorn, Merja; Ruuska, Tarja; Hiltunen, Pauliina; Visakorpi, J. K.; Mäki, Markku; Kurppa, Kalle

doi:10.1016/j.jpeds.2015.07.057

Cited by 80 publications

(89 citation statements)

References 43 publications

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“…20,[41][42][43] Apart from differences in study designs these discrepancies might be at least partly explained by differences in clinical presentation of the disease between countries. During recent decades, studies from many developed countries have reported that the severity of celiac disease is becoming milder even in the subgroup of patients suffering from classical gastrointestinal symptoms, 44,45 which may contribute to the increasing similarity between clinically and screen-detected children. Nevertheless, in favor of early diagnosis and treatment, more than half of the children in both groups here already had either moderate or total villous atrophy at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Kivelä

Kaukinen

Huhtala

et al. 2017

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 99%

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Kivelä

Kaukinen

Huhtala

et al. 2017

The Journal of Pediatrics

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“…1 Recent screening studies have revealed the prevalence to be as high as 1-2% (2,3). The only treatment for the condition is a permanent gluten-free diet, which usually results in beneficial clinical, histological and serological response (4).…”

Section: What Is Knownmentioning

confidence: 99%

Anemia and Iron Deficiency in Children With Potential Celiac Disease

Repo

Lindfors

Mäki

et al. 2017

J. pediatr. gastroenterol. nutr.

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contributed the conception and design of the work and revised the text for important intellectual content. All authors approved the final version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. AbstractObjectives: Active screening for celiac disease frequently detects seropositive children with normal villous morphology (potential celiac disease). It remains unclear whether these subjects should be treated. We here investigated the prevalence of anemia and iron deficiency in children with potential and mucosal atrophy celiac disease.Methods: The prospective study involved 19 children with potential disease, 67 with partial or subtotal villous atrophy (P/SVA) and 16 with total villous atrophy (TVA). Twenty-three healthy children comprised the control group. The groups were compared for various clinical, histological and laboratory parameters and hepcidin.Results: The prevalence of abnormal parameters was as follows (controls, potential celiac disease, P/SVA and TVA, respectively): anemia 0%, 15%, 22% and 63%; low iron 5%, 0%, 14% and 50%; increased transferrin receptor 1 (TfR1) 5%, 16%, 20% and 47%; low ferritin 0%, 21%, 35% and 87%; and low transferrin saturation 10%, 11%, 41% and 71%. One subject had low folate and none had low vitamin B12. The median values for hemoglobin, total iron, ferritin and transferrin saturation were significantly lower and TfR1 values higher in TVA group compared with other groups. After a median of seven months on a gluten-free diet hemoglobin, total iron, ferritin and albumin in children with P/SVA exceeded the baseline values in the potential celiac disease group.Conclusions: The development of anemia and iron deficiency in celiac disease is a continuum and may already be present in children with normal villous morphology, advocating an early diagnosis and possible dietary treatment of these patients.

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“…Currently most patients remain undiagnosed, but the clinical prevalence has also increased rapidly, being now for example in the Scandinavian countries more than 0.5% [3][4][5]. The major reason for the improved diagnostic efficacy is recognition of the diversity of the clinical picture, including a variety of extra-intestinal symptoms [6,7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors of abnormal liver values in children with celiac disease

Äärelä

Nurminen

Kivelä

et al. 2016

Digestive and Liver Disease

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Presentation of Celiac Disease in Finnish Children Is No Longer Changing: A 50-Year Perspective

Cited by 80 publications

References 43 publications

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Anemia and Iron Deficiency in Children With Potential Celiac Disease

Prevalence and associated factors of abnormal liver values in children with celiac disease

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