Presenting symptoms of glioma in adults

Posti, Jussi P.; Bori_, Mauricio; Kauko, Tommi; Sankinen, Matti; Nordberg, Janne; Rahi, Melissa; Frantzén, Janek; Vuorinen, Ville; Sipilä, Jussi

doi:10.1111/ane.12285

Cited by 79 publications

(55 citation statements)

References 29 publications

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“…The typical clinical presentation in patients with LGG is seizures. 14,15 In our study, older patients presented more frequently with focal deficits and lower performance status, and less often with seizures. These results are in line with the previously published report by Kaloshi and co-workers.…”

Section: Discussionsupporting

confidence: 49%

Age and surgical outcome of low-grade glioma in Sweden

et al. 2018

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Section: Discussionsupporting

confidence: 49%

Age and surgical outcome of low-grade glioma in Sweden

et al. 2018

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“…Unlike others 2,20,21,23,24 we did not find SP patients to be significantly younger than nSP when considering all grades of glioma. However, we did find that SP was more common among younger patients using an age-adjusted rate of SP in grade IV patients.…”

Section: Agecontrasting

confidence: 98%

“…Overall 43% in our cohort were SP well within the range (32% to 86%) reported in the systematic review by Su of all glioma grades 25 . As in our cohort (all six Grade II were SP) others report a greater prevalence of SP in LGG 20,21,23,26 . These LGG tumors are slowing growing which may create areas of cortical denervation hypersensitivity that give rise to seizures.…”

Section: Tumor Pathologysupporting

confidence: 73%

“…Our findings are similar to Lynam's group 26 with a preponderance of tumors for SP patients located in (in order of occurrence) parietal, temporal, and frontal lobes. Other groups have found no difference in SP status by tumor location 21,23 .…”

Section: Tumor Location Lobes and Lateralitymentioning

confidence: 89%

“…While there are hemispheric links based on the dominant side to cognitive disorders in glioma, seizures in glioma are not similarly associated 23 . As with others 21,23 we found no association between laterality and seizure presentation. Interestingly, we observed that a greater proportion of right-sided tumors were nSP (62%) compared to SP (38%) while left-sided tumors had equal proportions (SP, 49%, nSP 51%).…”

Section: Tumor Location Lobes and Lateralitymentioning

confidence: 99%

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Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

Johnston

Khurana

Whitmire

et al. 2019

Preprint

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BackgroundBrain tumor related epilepsy (BTE) is a major co-morbidity related to the management of patients with brain cancer. Despite published practice guidelines recommending against anti-epileptic drug (AED) utilization in patients with gliomas, there is heterogeneity in prescription practices of AEDs in these patients. In an attempt to impact BTE management, we statistically analyzed clinically relevant attributes (sex, age, tumor size, tumor growth kinetics, and tumor location) pertaining to seizure at presentation and used them to build a computational machine learning model to predict the probability of a seizure (at presentation). Methods From our clinical data repository, we identified 223 patients (females, n=86; males, n=137) with pathologicallydetermined glioma and known seizure status at clinical presentation. Non-parametric and Fisher's Exact tests were used to identify statistical differences in clinical characteristics. We utilized a random forest machine learning method for generating our predictive models by entire cohort and separated by male and female. Findings Patients were divided into those that presented with seizure (SP, n=96, 43%; F, n= 28; M, n= 68) and those that presented without seizure (nSP, n=127, 57%, F n=58, M n=69). Females presented with seizures significantly less often than males (x 2 =6·28, p=0·01). SP patients had significantly smaller T1Gd radius compared to nSP (SP 11·30mm, nSP 18.66mm, p<0·0001). Tumor size and patient age were significant negative predictors for SP; patients with larger tumors, older age and less tumor diffusivity (p/D) were at lower risk for SP. Interpretation Despite heterogeneity across our patient cohort, there is strong evidence of a role for patient sex, tumor size, tumor invasion, and patient age in predicting the incidence of seizures at diagnosis. Future studies, with prospectively detailed data collection, may provide clearer insights into the incidence of seizures through a patient's treatment course.

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Pituitary neuroendocrine tumor: A neuropsychological comparison with intra‐axial tumor

Tang,

Fang,

Bie

et al. 2024

Ann Clin Transl Neurol

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ObjectiveDespite pituitary neuroendocrine tumor (PitNET) being extra‐axial tumors without direct damage to brain tissue, patients with PitNET exhibit neuropsychological impairments. However, it remains unclear whether there are neuropsychological differences between PitNET and intra‐axial tumors that directly destroy the brain parenchyma. This prospective study aims to clarify this distinction to inform decision‐making for intracranial tumors of diverse origins.MethodsA total of 146 patients with PitNET, 74 patients with glioma representing intra‐axial tumors, and 52 age‐, sex‐, and education‐matched healthy controls were recruited. All patients received standard treatment and postoperative rehabilitation. Clinical data were meticulously collected, and neuropsychological tests were administered to all participants both before and 3 months after surgery.ResultsBoth PitNET and glioma patients experience the dual burden of cognitive and affective deficits. However, the feature of these deficits differs substantially. In PitNET patients, the deficits are relatively mild and focal, whereas in glioma patients, they are severe and extensive. Specifically, PitNET patients exhibit deficits in memory, anxiety, and negative affect. In contrast, glioma patients display deficits in executive function, attention, anxiety, positive/negative affect, and empathy. Notably, except for persistent memory deficits, the majority of neuropsychological scores declines in PitNET patients are restorable and can reach improvement within a short period after standard surgical therapy and perioperative management. Conversely, glioma patients not only fail to show improvements but also demonstrate worsening in terms of general cognition and memory postoperatively.InterpretationAs an extra‐axial tumor, PitNET may exhibit distinctive cognitive and affective functioning compared to intra‐axial tumors, highlighting the need for specific treatment approaches for PitNET patients.

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Presenting symptoms of glioma in adults

Cited by 79 publications

References 29 publications

Age and surgical outcome of low-grade glioma in Sweden

Age and surgical outcome of low-grade glioma in Sweden

Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

Pituitary neuroendocrine tumor: A neuropsychological comparison with intra‐axial tumor

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