Preservation of a functionally intact neuronal network after global ischemia

Ja, Clemens; Eb, Smalstig; Bhagwandin, B; Ja, Panetta

doi:10.1016/0304-3940(94)90329-8

Cited by 2 publications

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References 15 publications

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“…Previous experiments showed that various types of cerebral ischemia in humans and animals are accompanied by hippocampal neuronal damage (major generator of τ-waves) [1,3,11] and decrease in τ-activity [3,12]. The hippocampus has a key role in higher nervous functions (e.g., orientation-and-exploratory behavior, attention, memory, learning, etc.)…”

Section: Resultsmentioning

confidence: 99%

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Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

2009

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We showed that 302 of 840 EEG parameters in old Wistar rats significantly change 3 h after bilateral carotid artery ligation. All animals (n=7) died 250+/-47 min after ligation. EEG power spectra had signs of suppression (increased d-activity, decreased t-activity, and increased low-frequency alpha-activity) or activation of CNS (decreased high-frequency alpha-activity and paroxysmal increase in beta-activity). The coherence, synchrony, and entropy of potentials were reduced in the majority of brain regions. This method and scheme of experiments are suitable for the search and study of anti-stroke drugs.

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Section: Resultsmentioning

confidence: 99%

“…Abscissa: time, sec. Left and right frontal region (1, 2); parietotemporal region(3,4); occipital region of the brain (5, 6). Calibration 70 µV.…”

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confidence: 99%

Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

2009

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Glial reaction in the hippocampus after global cardiogenic ischemia

Martins

Chadi

2001

Acta Cir. Bras.

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Many experimental surgerical procedures have been perfomed in the analyse of the phenomenon of brain trophism and plasticity, however undesirable intercorrence can occour leading to specific changes in the results that should be taken into attention. To study this issue we have promoted a transient cardiogenic interruption of the blood flow together with a transient occlusion of the bilateral common carotid arteries (2VO) in rats and analysed the state of activation of astrocyte and microglia by means of the glial fibrillary acidic protein (GFAP) and OX42 immunohistochemistry, respectively. Rats were submitted to incomplete global cerebral ischemia (IGCI) by occlusion of the bilateral carotid arteries for 30 minutes. During the IGCI surgical, some rats received a higher dose of the chloral hydrate anaesthesia which promoted a cardiogenic interruption of the blood flow (CIBF) for a period of 10 minutes followed by and prompt reperfusion. During that period, animals were submited to a cardiac massage and ventilated. Sham operation were made in control animals. Rats were killed and their brains processed 14 days after the surgery. The animals that have received a IGCI showed a slight astroglial and microglial reaction in all subfields of the hippocampal formation, however the animal submitted to CIBF showed a massive infiltration of the reactive astrocyte and microglia in CA1 subfield. This results demonstrated that a transient occlusion of the bilateral common carotid arteries leads to activation of glial cells in the hippocampus, however this response can be remarkable changed in animal developing a transient systemic hypoperfusion during surgery. Thus, an accurated monitoration of the hemodinamic condition of the animal has to be done in experimental models of brain ischemia and the results have to be analysed in view of this aspect.

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Preservation of a functionally intact neuronal network after global ischemia

Cited by 2 publications

References 15 publications

Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

Multiparameter Analysis of EEG in Old Wistar Rats after Bilateral Carotid Artery Ligation

Glial reaction in the hippocampus after global cardiogenic ischemia

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