Preservative-free fixed combination of bimatoprost and timolol in the evolution of compliance and treatment effectiveness in patients with primary open-angle glaucoma

Loskoutov, I. A.; Корнеева, А. В.

doi:10.21516/2072-0076-2018-11-2-95-101

ROJ

2018

DOI: 10.21516/2072-0076-2018-11-2-95-101

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Preservative-free fixed combination of bimatoprost and timolol in the evolution of compliance and treatment effectiveness in patients with primary open-angle glaucoma

I. A. Loskoutov¹,

А. В. Корнеева²

Abstract: Áåñêîíñåðâàíòíàÿ ôîðìà ôèêñèðîâàííîé êîìáèíàöèè áèìàòîïðîñòà è òèìîëîëà â ïîâûøåíèè êîìïëàåíñà è ýôôåêòèâíîñòè ëå÷åíèÿ ïàöèåíòîâ ñ ïåðâè÷íîé îòêðûòîóãîëüíîé ãëàóêîìîé È.À. Ëîñêóòîâ-ä-ð ìåä. íàóê, çàâåäóþùèé îôòàëüìîëîãè÷åñêèì îòäåëåíèåì 1 À.Â. Êîðíååâà-êàíä. ìåä. íàóê, âðà÷-îôòàëüìîëîã 2

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Intolerance of preservative-containing eye drops in a glaucoma patient: diagnostic and therapeutic challenges

Фролов

Kazakova

Душина

et al. 2020

BRSMU

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A patient presented to our clinic with stage Ia open-angle glaucoma of the right eye and stage IIa surgically corrected open-angle glaucoma of the left eye. The condition of the ocular surface was interpreted as toxic/allergic conjunctivitis provoked by brimonidine 0.15 %. Brimonidine was substituted with non-selective 0.5%; additionally, topical steroids were prescribed. After steroids were discontinued, some of the symptoms came back, including moderate hyperemia and conjunctival edema, which was interpreted as intolerance to a preservative contained in the eye drops. A decision was made to switch from the β-blocker to its preservative-free formulation; regular IOP monitoring was continued. IOP measured during the next visit was above tolerated, so a preservative-free form of the ocular hypotensive combination drug (an analog of prostaglandin 0.005% with non-selective β-blocker 0.5%) was introduced to the regimen, with further IOP monitoring. Because the initial diagnosis was wrong, damage to the ocular surface had been aggravated by inadequate therapy. Preservative-free hypotensive eye drops are beneficial for the corneal surface and have a positive effect on a patient’s adherence to the regimen.

show abstract

Intolerance of preservative-containing eye drops in a glaucoma patient: diagnostic and therapeutic challenges

Фролов

Kazakova

Душина

et al. 2020

BRSMU

View full text Add to dashboard Cite

show abstract

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Preservative-free fixed combination of bimatoprost and timolol in the evolution of compliance and treatment effectiveness in patients with primary open-angle glaucoma

Cited by 1 publication

References 46 publications

Intolerance of preservative-containing eye drops in a glaucoma patient: diagnostic and therapeutic challenges

Intolerance of preservative-containing eye drops in a glaucoma patient: diagnostic and therapeutic challenges

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