Preserved hippocampus activation in normal aging as revealed by fMRI

Persson, Jonas; Kalpouzos, Grégoria; Nilsson, Lars‐Göran; Ryberg, Mats; Nyberg, Lars

doi:10.1002/hipo.20794

Cited by 53 publications

(39 citation statements)

References 59 publications

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“…1G). Notably, in keeping with previous findings [ (Schacter and Wagner, 1999;Persson et al, 2011], bilateral anterior hippocampus was differentially more engaged during episodic encoding. This effect might reflect binding processes that are of particular relevance for the formation of new associations in memory (Chua et al, 2007).…”

Section: Discussionsupporting

confidence: 91%

“…It has been debated whether hippocampal structure and function is affected in normal, nonpathological aging (for review, see Buckner, 2004;Hedden and Gabrieli, 2004). Some previous studies reported age-related hippocampus hypoactivation (Gutchess et al, 2005;Daselaar et al, 2006), whereas others found preservation of hippocampus responses across the examined age span (Persson et al, 2011). The present results indicate that age-related reductions in hippocampal functional responses are relatively minor before age 70, suggesting that differences in age ranges across studies may account for some between-studies discrepancies.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Opposing Effects of Aging on Large-Scale Brain Systems for Memory Encoding and Cognitive Control

Salami¹,

Eriksson²,

Nyberg³

2012

Journal of Neuroscience

104

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Episodic memory declines with advancing age. Neuroimaging studies have associated such decline to age-related changes in general cognitive-control networks as well as to changes in process-specific encoding or retrieval networks. To assess the specific influence of aging on encoding and retrieval processes and associated brain systems, it is vital to dissociate encoding and retrieval from each other and from shared cognitive-control processes. We used multivariate partial-least-squares to analyze functional magnetic resonance imaging data from a large population-based sample (n ϭ 292, 25-80 years). The participants performed a face-name paired-associates task and an active baseline task. The analysis revealed two significant network patterns. The first reflected a process-general encoding-retrieval network that included frontoparietal cortices and posterior hippocampus. The second pattern dissociated encoding and retrieval networks. The anterior hippocampus was differentially engaged during encoding. Brain scores, representing whole-brain integrated measures of how strongly an individual recruited a brain network, were correlated with cognitive performance and chronological age. The scores from the general cognitive-control network correlated negatively with episodic memory performance and positively with age. The encoding brain scores, which strongly reflected hippocampal functioning, correlated positively with episodic memory performance and negatively with age. Univariate analyses confirmed that bilateral hippocampus showed the most pronounced activity reduction in older age, and brain structure analyses found that the activity reduction partly related to hippocampus atrophy. Collectively, these findings suggest that age-related structural brain changes underlie age-related reductions in the efficient recruitment of a process-specific encoding network, which cascades into upregulated recruitment of a general cognitive-control network.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 52%

Opposing Effects of Aging on Large-Scale Brain Systems for Memory Encoding and Cognitive Control

Salami¹,

Eriksson²,

Nyberg³

2012

Journal of Neuroscience

104

View full text Add to dashboard Cite

show abstract

“…In addition, more activation in old adults can sometimes be associated with poorer, not better, performance 54 . Recent studies have reported greater activity in the PFC during memory encoding 55 or retrieval 56 in older adults, both of which were correlated with poorer memory. Similarly, higher activity in a distributed set of regions, including PFC and parietal cortex, in old adults compared to young adults 57,58 was found to be correlated with slower and more variable reaction times on a set of visual tasks.…”

Section: Compensation In the Older Brainmentioning

confidence: 96%

The cognitive neuroscience of ageing

2012

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PrefaceThe availability of neuroimaging technology has spurred a marked increase in the human cognitive neuroscience literature, including the study of cognitive aging. Although there is a growing consensus that the aging brain retains considerable plasticity of function, currently measured primarily by means of functional magnetic resonance imaging, it is less clear how age differences in brain activity relate to cognitive performance. The field also is hampered by the complexity of the aging process itself and the large number of factors that are influenced by age. In this review, current trends and unresolved issues in the cognitive neuroscience of aging are discussed.

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“…Scanner task. The episodic memory task used was a face-name pairedassociate task (adopted from Persson et al, 2011). A blocked design consisting of three conditions was used: encoding, retrieval, and control/ baseline.…”

Section: Brain Imaging Study (Functional Mri)mentioning

confidence: 99%

KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing

Kauppi

Nilsson²,

Adolfsson³

et al. 2011

J. Neurosci.

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Several studies have linked the KIBRA rs17070145 T polymorphism to superior episodic memory in healthy humans. One study investigated the effect of KIBRA on brain activation patterns (Papassotiropoulos et al., 2006) and observed increased hippocampal activation in noncarriers of the T allele during retrieval. Noncarriers were interpreted to need more hippocampal activation to reach the same performance level as T carriers. Using large behavioral (N ϭ 2230) and fMRI (N ϭ 83) samples, we replicated the KIBRA effect on episodic memory performance, but found increased hippocampal activation in T carriers during episodic retrieval. There was no evidence of compensatory brain activation in noncarriers within the hippocampal region. In the main fMRI sample, T carriers performed better than noncarriers during scanning but, importantly, the difference in hippocampus activation remained after post hoc matching according to performance, sex, and age (N ϭ 64). These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.

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Preserved hippocampus activation in normal aging as revealed by fMRI

Cited by 53 publications

References 59 publications

Opposing Effects of Aging on Large-Scale Brain Systems for Memory Encoding and Cognitive Control

Opposing Effects of Aging on Large-Scale Brain Systems for Memory Encoding and Cognitive Control

The cognitive neuroscience of ageing

KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing

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