Preserved subcortical volumes and cortical thickness in women with sexual abuse-related PTSD

Landré, Lionel; Destrieux, Christophe; Baudry, Marion; Barantin, Laurent; Cottier, Jean-Philippe; Martineau, J.; Hommet, Caroline; Isingrini, Michel; Belzung, Catherine; Gaillard, Philippe; Camus, Vincent; El‐Hage, Wissam

doi:10.1016/j.pscychresns.2010.01.015

Cited by 61 publications

(45 citation statements)

References 64 publications

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“…The prefrontal areas whose reduction in PTSD patients has been reported are not identical for all authors. Some have reported no changes in prefrontal cortex thickness or volume in the brain in PTSD patients (331). This issue is far from fully settled and awaits further study.…”

Section: Fear Extinction and Its Relation With Exposure Therapy Fomentioning

confidence: 94%

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Fear Memory

Izquierdo

Furini

Myskiw

2016

Physiological Reviews

384

259

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Fear memory is the best-studied form of memory. It was thoroughly investigated in the past 60 years mostly using two classical conditioning procedures (contextual fear conditioning and fear conditioning to a tone) and one instrumental procedure (one-trial inhibitory avoidance). Fear memory is formed in the hippocampus (contextual conditioning and inhibitory avoidance), in the basolateral amygdala (inhibitory avoidance), and in the lateral amygdala (conditioning to a tone). The circuitry involves, in addition, the pre-and infralimbic ventromedial prefrontal cortex, the central amygdala subnuclei, and the dentate gyrus. Fear learning models, notably inhibitory avoidance, have also been very useful for the analysis of the biochemical mechanisms of memory consolidation as a whole. These studies have capitalized on in vitro observations on long-term potentiation and other kinds of plasticity. The effect of a very large number of drugs on fear learning has been intensively studied, often as a prelude to the investigation of effects on anxiety. The extinction of fear learning involves to an extent a reversal of the flow of information in the mentioned structures and is used in the therapy of posttraumatic stress disorder and fear memories in general.

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Section: Fear Extinction and Its Relation With Exposure Therapy Fomentioning

confidence: 94%

“…Several authors have reported reduced prefrontal cortex thickness in PTSD patients (78,198,325,352,419,420,422,521), while others who have looked for this have not (331). The prefrontal areas whose reduction in PTSD patients has been reported are not identical for all authors.…”

Section: Fear Extinction and Its Relation With Exposure Therapy Fomentioning

confidence: 95%

Fear Memory

Izquierdo

Furini

Myskiw

2016

Physiological Reviews

384

259

View full text Add to dashboard Cite

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“…This could result in specific alterations of regional brain volumes. Research with female populations generally fails to find GM volume differences associated with PTSD (22). These null findings may be in part due to higher levels of dissociative PTSD in women with sexual childhood abuse-related PTSD.…”

Section: Introductionmentioning

confidence: 91%

Structural brain aberrations associated with the dissociative subtype of post‐traumatic stress disorder

Daniels

Frewen

Théberge

et al. 2015

Acta Psychiatr Scand

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“…Results from a structural MRI experiment using the same participants demonstrated no brain morphologic differences between these groups that could explain functional variations. 21 …”

Section: Group Analysismentioning

confidence: 99%

“…Interestingly, the structural brain alterations observed in women with PTSD related to sexual abuse are not consistent with those classically observed in men with PTSD. 21 Moreover, recent metaanalytic work has revealed few, if any, deficits in verbal memory for sexual abuse-related PTSD compared with war trauma-related PTSD, 7 with no significant effect observed in studies involving trauma-exposed, non-PTSD control groups. Because most victims of sexual abuse are women, this result indicates potential trauma-type or sex effects in neurocognitive manifestations of PTSD that might be further considered through experiments with both men and women who experienced various types of trauma.…”

Section: Limitationsmentioning

confidence: 99%