Pressure pain thresholds in individuals with knee pain: a cross-sectional study

Sylwander, Charlotte; Larsson, Ingrid; Haglund, Emma; Bergman, Stefan; Andersson, Maria

doi:10.1186/s12891-021-04408-0

Cited by 14 publications

(21 citation statements)

References 55 publications

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“…Potential mechanisms regarding our metaregression result could include mechanical loading (e.g., increased joint load and altered walking kinematics in individuals with obesity compared with normal‐weight individuals) (80) and/or systemic factors such as metabolically driven inflammation in obesity (81) or pain sensitivity. Recent work has found that in those with knee pain, low pressure pain thresholds are associated with both higher visceral fat area and body fat percentage (82). This may in part explain why those studies with higher BMI (>28 kg/m 2 ) displayed a negative knee loading–pain relationship.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Hutchison

Grayson

Hiller

et al. 2022

Arthritis Care & Research

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Objective Our primary aim was to determine the cross‐sectional relationship between knee biomechanics during gait and pain in people with medial knee osteoarthritis. Our secondary aim was to evaluate differences in knee biomechanics between symptomatic and asymptomatic participants with medial knee osteoarthritis. Methods Four online databases were searched from inception to July 2021. Eligible studies included people with medial/nonspecific knee osteoarthritis and a reported relationship between knee biomechanics during gait and pain or biomechanics of symptomatic and asymptomatic participants. Two reviewers independently extracted data and evaluated risk of bias. Random‐effects meta‐analyses were performed when three or more studies reported the same biomechanical variable for pooling (knee adduction moment [KAM], KAM impulse, varus thrust, and peak knee flexion moment [KFM]). Results Forty studies were included. Methodological quality ranged from 4 to 9/10. Forty‐seven unique biomechanical variables were reported. For the KAM, there was no correlation with pain for peak values pooled (early stance and overall) (r = 0.00, 95% confidence interval [95% CI]: −0.12, 0.11, k = 16), a small negative correlation for early stance peak alone (r = −0.09, 95% CI −0.18, −0.002, k = 12), and a medium positive correlation for the overall peak during stance (r = 0.30, 95% CI 0.17, 0.42, k = 4). Metaregression identified that body mass index moderated the peak KAM–pain relationship (P < 0.001). KAM impulse had a small positive correlation with pain (r = 0.23, 95% CI 0.04, 0.40, k = 5), and people with varus thrust had 3.84 greater odds of reporting pain compared with people without (95% CI 1.72, 8.53, k = 3). Meta‐analyses for the peak KFM and pain correlation and secondary aim were nonsignificant. Conclusion Some knee gait biomechanics were associated with pain in this cohort. Longitudinal studies are required to determine causality.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Hutchison

Grayson

Hiller

et al. 2022

Arthritis Care & Research

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“…The study was based on an ongoing longitudinal cohort study (the Halland Knee Osteoarthritis cohort study, HALLOA) that included 306 individuals with knee pain in Southwest Sweden, as described in detail elsewhere [ 7 ]. Participants from the HALLOA study who had performed the two-year follow-up after inclusion were eligible for the current study (n = 101).…”

Section: Methodsmentioning

confidence: 99%

“…KOA can cause chronic pain, impaired physical function, diminished quality of life [ 4 ], and affects workability [ 5 ]. Individuals with knee pain also have a higher risk of developing chronic widespread pain (CWP) [ 6 ], and in a previous study the prevalence of CWP was 38% of those with knee pain [ 7 ]. Health is more than the absence of disease; it is a state of physical, mental, and social well-being [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Experiences of How Health and Lifestyle among Individuals with Knee Pain Have Been Influenced during the COVID-19 Pandemic, a HALLOA Study

Sunesson

Sylwander

Haglund

et al. 2022

IJERPH

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The COVID-19 pandemic has affected the health and lifestyles of both the general population and of vulnerable groups. Individuals with knee pain are recommended to lead an active lifestyle to relieve pain but find it difficult to maintain health and lifestyle compared to the general population due to the cause of chronic pain, impaired physical function, and a diminished quality of life. This study aimed to explore experiences of how health and lifestyle among individuals with knee pain have been influenced during the COVID-19 pandemic. Interviews (n = 19) were conducted in 2021 and analysed with qualitative content analysis. The results showed how individuals with knee pain adjusted their behaviour and revalued their life to maintain health and lifestyle during COVID-19. Adjusted behaviours emerged, such as spending more time at home, becoming digital, and spending more time outdoors, while revaluing life emerged as having a positive outlook on life and sharing responsibility. In conclusion, behaviour was adjusted, and life revalued to manage health and lifestyle during the pandemic. However, the findings are probably similar to the general population, i.e., individuals with knee pain live similar lives as the general population despite knee pain. The results may contribute to alternative ways of maintaining health and lifestyle in various vulnerable groups and may be applied in situations other than the pandemic.

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“…Longitudinal studies are needed to further investigate the associations. 64 In a study of baseline data with the aim to refine and assess the validity of an algorithm to detect lying down from raw data of thigh-worn accelerometers, we have found that the refined algorithm can be used to estimate lying time in studies using different accelerometer brands. 47…”

Section: Findings To Datementioning

confidence: 99%

“…In a study aimed to (1) investigate pain sensitivity, assessed by PPTs, among women and men with knee pain and (2) associations with, respectively, radiographic knee OA, CWP and overweight/obesity, we found that modifiable factors, increased VFA and body fat could be associated with increased pain sensitivity among individuals with knee pain. Longitudinal studies are needed to further investigate the associations 64…”

Section: Findings To Datementioning

confidence: 99%

Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden

et al. 2022

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PurposeThe overall objective in this study is to investigate the early development of radiographic knee osteoarthritis (OA) and its association with hand or/and knee OA, metabolic diseases, biomarkers, chronic pain, physical function and daily physical activity types.ParticipantsThe Halland osteoarthritis (HALLOA) cohort is a longitudinal cohort study that includes individuals with knee pain in the southwest of Sweden. Enrolment took place from 2017 to 2019. The inclusion criteria were current knee pain, with no former known radiographic knee OA and no cruciate ligament rupture or rheumatological disorder. The participants were recruited: (1) when seeking care for knee pain in primary healthcare or (2) by advertisements in local newspapers. There are 306 individuals included in the study, mean age (SD) 51.7 (8.7) years and 69% are women. The baseline and follow-ups include clinical tests, radiographical examinations, blood samples, metabolic measures, pain pressure thresholds, tests of physical functions, daily physical activity types and patient-reported outcomes.Findings to dateThere were associations between metabolic factors and radiographic knee OA, even in those with normal body mass index at baseline. In addition, clinical hand OA was positively associated with fasting plasma glucose. We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.Future plansBy studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment.Trial registration numberClinicalTrials.gov (NCT04928170).

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Pressure pain thresholds in individuals with knee pain: a cross-sectional study

Cited by 14 publications

References 55 publications

Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Relationship Between Knee Biomechanics and Pain in People With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Experiences of How Health and Lifestyle among Individuals with Knee Pain Have Been Influenced during the COVID-19 Pandemic, a HALLOA Study

Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden

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