Pressure-sensitive mucoadhesive polymer-based dental patches to treat periodontal diseases: anin vitrostudy

Abstract

Local drug delivery for periodontal diseases is still a challenge due to very short residence time, involuntary swallowing and salivary wash-out. Present study is, therefore, an attempt to develop pressure-sensitive adhesive polymers-based mucoadhesive dental patches to ensure satisfactory prolonged release of drugs, to treat periodontal diseases locally. Polymers such as duro-tak Õ 387-2516 and duro-tak Õ 387, ethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol along with drugs amoxicillin trihydrate and diclofenac sodium were used to develop the experimental patches. The patches were characterized for mass variation, thickness, area, moisture-content and moisture-uptake, folding endurance, structural integrity in simulated saliva, bioadhesive strength, surface pH, scanning electron microscopy, cellular morphology, in vitro drug release and temperature-dependant stability study as per ICH guideline. Incorporation of release enhancers in the patches improved drug release. Drugs released in a sustained manner due to the formation of physical bonds between the polymers (as assessed by FTIR study) which might alter the length of drug diffusion pathways. The formulation F3 with tween 80 as release enhancer provided best drug release profile over the period of 8 h, thus it could be a successful attempt for the management of oral pathogens and dental pain.

Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection

“…Amounts of drug release of FP1 and FP2 in SLF at different time points were found to be generally more (except a few cases where the values were marginally less) than those in PBS at the respective time points. The R 2 values and rate constants/release exponent values determined from the data of drug release following different kinetic models 26 are given in Table 2. More linearity (by assessing R 2 values) was detected in the Korsmeyer−Peppas plot (R 2 = 0.970, 0.921 for FP1, FP2, respectively) followed by Higuchi's (R 2 = 0.952, 0.928 for FP1, FP2, respectively) in SLF.…”

Present and Future Treatment Modalities for the Mitigation and Cure of Periodontal Diseases

“…In a different study, Manasadeepa et al [102] reported about formulating and characterizing an innovative dental patch with efficient mucoadhesive properties and pressure sensitiveness. Polymers with confirmed biocompatibility, biodegradability and non-toxicity were chosen for developing this type of formulation.…”

Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers

“…The cross-linked PVP hydrogels have been representatively used as adhesives that can be readily adhered to wet biological tissues. 20,21 The inclusion of PCL fibers in the core along with the adhesive PVP parts in the exterior sheaths was necessary to overcome the PVP's lack of mechanical strength. Most importantly, the proposed tissue adhesives were spontaneously composed of multiple fibrous layers, which were formed via salt-induced electrospinning.…”

“…A building-block portion, poly­(ε-caprolactone) (PCL; core), with an adhesive material, poly­(vinylpyrrolidone) (PVP; sheath), were successfully merged by coaxial-electrospinning of the dual materials (i.e., PCL@PVP matrices). The cross-linked PVP hydrogels have been representatively used as adhesives that can be readily adhered to wet biological tissues. , The inclusion of PCL fibers in the core along with the adhesive PVP parts in the exterior sheaths was necessary to overcome the PVP’s lack of mechanical strength. Most importantly, the proposed tissue adhesives were spontaneously composed of multiple fibrous layers, which were formed via salt-induced electrospinning .…”