Pressure waves and gradients in the canine thoracic duct

Browse, N L; Lord, Reginald S. A.; Taylor, A. E.

doi:10.1113/jphysiol.1971.sp009396

Cited by 20 publications

(16 citation statements)

References 4 publications

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“…The present findings coincide well with these findings. This nonlinearity, in part, might be due to the characteristics of collapsible lymphatic vessels (BROWSE et al, 1969). The conductance of fluid movement from the interstitial space to the thoracic duct estimated by dividing the increase of lymph flow by the increase of interstitial pressure was about 0.0125 ml/mmHg .…”

Section: Discussionmentioning

confidence: 99%

Transvascular fluid shift and thoracic duct lymph: Analysis of lymph formation in the rat.

1984

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To analyze the effect of changes in interstitial fluid on lymph production, intravascular infusions of saline were given to splenectomized rats under pentobarbital anesthesia at 3 different rates (2, 3, and 4 ml/ 100 g of body weight) over 10 min. Change of blood volume was continuously monitored and, simultaneously, thoracic duct lymph was collected during and after the infusion. Equilibrium was attained approximately 40 min after the infusion; regardless of the infusion rate, 10 % of the infused volume was incorporated into the vascular space and 90 % was filtered into the extravascular space. Thus, the amount of transvascular fluid shift showed a linear relationship with the infused volume. However, the drainage from thoracic duct lymph amounted to 5.9 %, 11.4%, and 17.8 % of the infused saline volume when given at the rate of 2, 3, and 4 ml/ 100 g, respectively. The relation of lymph flow and infused volume could be regarded as a nonlinear system. By means of a simulation study, this relation was found to be attributed to the nonlinearity of conductance for fluid movement from tissue to lymph duct, which was only one sixth of that determined for the capillary membrane. The drainage of lymph protein following the infusion was only about 50% of that expected from the interstitial protein concentration in even distribution of the infused saline. These characteristics of interstitial fluid space play an important role in absorbing water and, hence, buffering changes in circulating blood volume after volume loading.

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Section: Discussionmentioning

confidence: 99%

Transvascular fluid shift and thoracic duct lymph: Analysis of lymph formation in the rat.

1984

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“…In the anaesthetized dog there are pressure differences of between 2 and 5 mmHg between the abdominal and thoracic ducts, and between the thoracic duct and the great vessels (Browse et al 1971). The duct perfusion study, in which the velocity of flow was measured, shows that such pressure differences produce velocities of flow between 1 and 2-5 cm/sec.…”

Section: Discussionmentioning

confidence: 99%

“…4). This 408 VELOCITY OF LYMPH FLOW IN THORACIC DUCT 409 increase in flow after drinking corresponds to the increased pressure gradient that has been observed after drinking (Browse et al 1971).…”

Section: Velocity Offlow In Conscious Dogsmentioning

confidence: 92%

“…There is always some flow along the thoracic duct because lymph formation in the viscera is a continuous process. Recently we showed that the cause of thoracic duct lymph flow in the dog is the pressure gradient between the abdomen and the chest, and between the thoracic duct and the great veins (Browse, Lord & Taylor, 1971). However, as these studies showed that the gradients are very small, only 0-5-2 mmHg, we decided to investigate the velocity and magnitude of lymph flow that they could produce.…”

Section: Introductionmentioning

confidence: 99%

“…When the cisterns were full the pump was turned off. In the conscious animals the lipiodol was injected into the abdominal lymph cisterns through a catheter which had been inserted into them via a small tributary 1 week previously, using an extraperitoneal approach and an incision in the left loin (Browse et al 1971 Rutt & Taylor, 1969). The videotape was analysed by placing a grid drawn on a polythene sheet, corresponding to the X-ray image of the 1 cm grid placed during the experiment on the side of the animal, over the whole image on the television screen.…”

Section: Introductionmentioning

confidence: 99%

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The velocity of lymph flow in the canine thoracic duct

Browse¹,

Rutt²,

Sizeland³

et al. 1974

The Journal of Physiology

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SUMMARY1. The velocity and pattern of movement of lymph in the thoracic duct of anaesthetized and conscious dogs has been studied by observing the movement of droplets of ultrafluid lipiodol in the duct.2. The velocity of flow when anaesthetized varied from 0 1-2'0 cm/sec, to 5-0 cm/sec when conscious.3. The pattern of flow was affected by respiration and the cardiac cycle. Most movement occurred at the end of inspiration.4. The duct of five autopsy preparations was perfused with saline to assess the volume and velocity of flow produced by the level of pressure gradients previously observed in the duct. These studies show that the small gradients (2-5 mmHg) observed during life are more than sufficient to produce the normal volume and velocity of flow measured. The mean resistance of the duct was 05 mmHg/ml. min.

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Hodgkin's disease: Unfolding concepts concerning its nature, management and prognosis

Kaplan

1980

Cancer

180

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The evolution of our concepts concerning the fundamental nature and natural history of Hodgkin's disease is reviewed. Recent evidence establishes that it is indeed a malignant neoplasm, albeit a curious one, the giant cells of which display aneuploid karyotypes, often with marker chromosomes indicating their clonal derivation, and the functional and surface marker properties of cells of the mononuclear phagocyte series. The disease tends initially to spread by contiguity from one lymph node chain to others with which direct lymphatic channel communications exist. Essentially all patients, even those with limited disease, have some degree of impairment of cell-mediated immunity, apparently due to inhibition of T-lymphoc,yte function. Lymphangiography, computed tomography, and laparotomy with splenectomy have greatly improved the accuracy of clinical staging. Total lymphoid megavoltage radiotherapy andlor multidrug combination chemotherapy now permit the eradication of disease of all stages, resulting in a dramatic impruvement in prognosis and an increasing frequency of permanent cure of this once inevitably fatal condition. Cancer 452439-2474. 1980. T IS NOW ALMOST 150 YEARS since Thomas Hodgkin

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Pressure waves and gradients in the canine thoracic duct

Cited by 20 publications

References 4 publications

Transvascular fluid shift and thoracic duct lymph: Analysis of lymph formation in the rat.

Transvascular fluid shift and thoracic duct lymph: Analysis of lymph formation in the rat.

The velocity of lymph flow in the canine thoracic duct

Hodgkin's disease: Unfolding concepts concerning its nature, management and prognosis

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