Pressurized liquid extraction of medicinal plants

Benthin, Björn; Danz, Henning; Hamburger, Matthias

doi:10.1016/s0021-9673(99)00071-0

Cited by 192 publications

(98 citation statements)

References 5 publications

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“…In order to enhance extraction efficiency, additional energy is put into the system either directly by heat (e.g. 70 • C), or by other techniques such as pressurized liquid extraction (Benthin et al, 1999), supercritical fluid extraction (Castioni et al, 1995;Jarvis and Morgan, 1997;Blanch et al, 1999), sonication (Sargenti and Vichnewski, 2000), subcritical water extraction (Gámiz-Gracia and de Castro, 2000), microwave techniques (Namiesnik and Gorecki, 2000), or pervaporation (Starmans and Nijhuis, 1996). Rarely data are available that compare these techniques and, furthermore, few systematic studies have been carried out on the occurrence of possible metabolite breakdown reactions caused, for example, by oxidation (Peng and Jayallemand, 1991).…”

Section: Metabolomic Sample Preparationmentioning

confidence: 99%

Metabolomics — the link between genotypes and phenotypes

Fiehn

2002

Functional Genomics

1,624

1,337

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Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel to the terms 'transcriptome' and 'proteome', the set of metabolites synthesized by a biological system constitute its 'metabolome'. Yet, unlike other functional genomics approaches, the unbiased simultaneous identification and quantification of plant metabolomes has been largely neglected. Until recently, most analyses were restricted to profiling selected classes of compounds, or to fingerprinting metabolic changes without sufficient analytical resolution to determine metabolite levels and identities individually. As a prerequisite for metabolomic analysis, careful consideration of the methods employed for tissue extraction, sample preparation, data acquisition, and data mining must be taken. In this review, the differences among metabolite target analysis, metabolite profiling, and metabolic fingerprinting are clarified, and terms are defined. Current approaches are examined, and potential applications are summarized with a special emphasis on data mining and mathematical modelling of metabolism.

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Section: Metabolomic Sample Preparationmentioning

confidence: 99%

Metabolomics — the link between genotypes and phenotypes

Fiehn

2002

Functional Genomics

1,624

1,337

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“…It separates compounds from the cellular matrix, and exhaustive extraction should be performed. Ideally, the extraction method should be simple, rapid, and inexpensive for routine analysis (Benthin et al, 1999;Ong, 2004).…”

Section: Introductionmentioning

confidence: 99%

Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods

Pothitirat

Chomnawang

Supabphol

et al. 2009

Pharmaceutical Biology

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“…Since PFE uses less solvent in a shorter period of time, is automated, and involves retaining the sample in an oxygen and light-free environment, it has the potential to be a powerful tool in the nutraceutical industry. Recent applications have demonstrated the advantage of PFE for the extraction of natural products from plant materials [3][4][5][6][7][8][9]. Other biological applications include the extraction of fatty acids from plant and animal matrices [10] and the determination of zearalenone mycotoxin in corn * Correspondence author.…”

Section: Introductionmentioning

confidence: 99%

Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum

Denery

Dragull

Tang

et al. 2004

Analytica Chimica Acta

147

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Pressurized fluid extraction (PFE) was examined as an alternative technology for the extraction of carotenoids in the green algae Haematococcus pluvialis and Dunaliella salina and kavalactones in Piper methysticum. The extraction process was optimized by varying the key extraction factors of solvent, sample-solvent ratio, temperature, and time. The selectivity and efficiency of extraction parameters were determined with high performance liquid chromatography (LC) and LC-mass spectrometry (LC-MS). Results showed that PFE utilization of conventional solvents under controlled temperature and pressure in an oxygen and light-free environment could result in the use of less solvent in a shorter period of time. PFE showed higher or equal extraction efficiencies as compared with traditional solvent extractions while maintaining the integrity of chemical components. PFE showed high potential for extraction of natural products and nutraceuticals, particularly labile and light sensitive chemicals.

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Pressurized liquid extraction of medicinal plants

Cited by 192 publications

References 5 publications

Metabolomics — the link between genotypes and phenotypes

Metabolomics — the link between genotypes and phenotypes

Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods

Pressurized fluid extraction of carotenoids from Haematococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum

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