Prestatiebevorderende middelen in de sport

Kenney, Larry W.; Wilmore, Jack H.; Costill, David L.; Lindauer, Ramón

doi:10.1007/978-90-368-2921-2_18

Cited by 7 publications

(12 citation statements)

References 72 publications

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“…Here, we found no changes in peak V̇O 2 (mean values of ∼28 ± 7 mL ⋅kg·min −1 ) over the course of the study, and this is inconsistent with most previous work on FBC or other cancer survivors [51–56]. However, our data on CPET in male patients are presented for the first time in the literature, which seems very important given the wealth of literature focusing exclusively on FBC and exercise, and the evidence of sex-differences in cardiovascular response to exercise [57]. The baseline peak V̇O 2 data reported here are ∼10% higher compared with the average normative reference values of healthy men in North America (∼23 mL⋅kg·min −1 ) in the age group between 60 and 69 years [58].…”

Section: Discussioncontrasting

confidence: 77%

“…This opens up the possibility that further increases in V̇O 2 peak were rather limited, in part due to the age of the participants in our study (MBC patients here were 60 years old). Indeed, cardiovascular plasticity deteriorates with age, limiting O 2 transport, and thus peak V̇O 2 during exercise [57]. Thus, it is reasonable to hypothesize that maintenance, rather than improvement of peak V̇O 2 was observed, likely due the age of the participants included here.…”

Section: Discussionmentioning

confidence: 97%

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Moderate Intensity Exercise Reduces Side Effects of Cancer Therapy and Maintains Cardiorespiratory Fitness in Male Breast Cancer Patients: Findings from the BRECA Male Crossover Study

Schultz,

Zubac,

Bloch

et al. 2023

Breast Care

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Introduction: There is growing evidence that aerobic exercise mitigates cancer therapy-related side effects and improves cardiorespiratory fitness (CRF). However, to the best of our knowledge, no exercise study has been conducted in male breast cancer (MBC) patients. The aim of this study was to investigate the feasibility and efficacy of different exercise intensities on CRF and self-reported questionnaire items in MBC patients. Methods: Twenty-two MBC patients (60 ± 9 years) participated in this randomized crossover study. After completion of medical treatment, MBC patients were randomly assigned to either moderate (40–50% of heart rate [HR] max. and self-perceived exertion: 11) or vigorous (70–80% of HR max. and self-perceived exertion: 15) exercise intensity during the first 3 months of the study. After a 1-month washout period, participants switched group assignments. Primary endpoints were CRF and questionnaire items. Results: We observed a dropout rate of 36% over 7 months, with the number of participants decreasing from 22 to 14. The results showed significant improvements in “Physical Function” (p = 0.037) and “Social Function” (p = 0.016) after moderate training. A non-significant improvement was also observed in “Breast Symptoms” (p = 0.095), but there was no change in “Fatigue” (p = 0.306). There were no differences observed in cardiovascular fitness (V̇O2 peak) between the treatment groups. Conclusion: This study emphasizes the effectiveness of exercise intervention for an exceedingly rare cancer, highlighting the vital role of moderate intensity aerobic exercise in mitigating treatment side effects. Despite minimal peak V̇O2 differences, both exercise protocols adequately sustain CRF. Future studies are imperative to design optimized, sex-specific rehabilitation strategies tailored to the unique requirements of MBC patients, advancing our understanding of this under explored realm.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 97%

Moderate Intensity Exercise Reduces Side Effects of Cancer Therapy and Maintains Cardiorespiratory Fitness in Male Breast Cancer Patients: Findings from the BRECA Male Crossover Study

Schultz,

Zubac,

Bloch

et al. 2023

Breast Care

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“…In our studies, this indicator exceeded 76% of VO2max in the case of CET and over 82% of VO 2max in the case of DSN. This result provides irrefutable proof of the high physical capacity of the people participating in some prior studies [44][45][46], and demonstrates that the DSN test meets all of the criteria needed to demonstrate its suitability for use in the assessment of human exercise capacity, similarly to the standardized CET test.…”

Section: Discussionmentioning

confidence: 68%

Body Loading during an Intensive Yoga Exercise Routine and a Cycle Ergometer Test

Stec

Pilis

et al. 2023

IJERPH

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The present study compared the effects on the cardiovascular, respiratory, and metabolic functions of the practice of an intensive yoga exercise routine called Dynamic Suryanamaskar (DSN) and a cycle ergometer test (CET) of increasing intensity. The study involved 18 middle-aged volunteers who had previously practiced DSN. The study was conducted in two series (i.e., as CET and DSN with similar intensity) until complete exhaustion. At rest (R), at the ventilatory anaerobic threshold (VAT), and at the maximum workload (ML), the variables characterizing cardiovascular, respiratory, and metabolic functions were determined. In addition, the subjective intensity of both efforts was determined using the Borg test. No functional differences were observed in the cardiovascular, respiratory, and metabolic systems at similar CET and DSN intensities. Respondents experienced less subjective workload during DSN than during CET (p < 0.001). Since DSN intensifies the activity of the cardiovascular, respiratory, and metabolic systems to a similar degree to CET both at VAT and ML, but causes less subjective fatigue, this yogic practice can be used as a laboratory exercise test and as an effective training medium.

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“…Muscle fatigue is usually a short-term and reversible process manifested as a lack of energy [1]. The main causes of fatigue are related to overexertion, insufficient relaxation time, or physical trauma [2,3]. However, muscle fatigue can be persistent and more severe when associated with pathological conditions, or chronic exposure to certain drugs and toxic compounds [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…We previously tested the powerful antioxidant properties of C 60 fullerenes in experiments on ischemia, fatigue, and skeletal muscle injury [24][25][26]. However, the development of fatigue involves processes at all levels of the motor pathway between the brain and muscles [3]. Central fatigue is the inability of the nervous system to maximize muscle control [7].…”

Section: Introductionmentioning

confidence: 99%

The Residual Effect of C60 Fullerene on Biomechanical and Biochemical Markers of the Muscle Soleus Fatigue Development in Rats

Prylutskyy

Nozdrenko

Gonchar

et al. 2023

Journal of Nanomaterials

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Muscle fatigue as a defense body mechanism against overload is a result of the products of incomplete oxygen oxidation such as reactive oxygen species. Hence, C60 fullerene as a powerful nanoantioxidant can be used to speed up the muscle recovery process after fatigue. Here, the residual effect of C60 fullerene on the biomechanical and biochemical markers of the development of muscle soleus fatigue in rats for 2 days after 5 days of its application was studied. The known antioxidant N-acetylcysteine (NAC) was used as a comparison drug. The atomic force microscopy to determine the size distribution of C60 fullerenes in an aqueous solution, the tensiometry of skeletal muscles, and the biochemical analysis of their tissues and rat blood were used in this study. It was found that after the cessation of NAC injections, the value of the integrated muscle power is already slightly different from the control (5%–7%) on the first day, and on the second day, it does not significantly differ from the control. At the same time, after the cessation of C60 fullerene injections, its residual effect was 45%–50% on the first day, and 17%–23% of the control on the second one. A significant difference (more than 25%) between the pro- and antioxidant balance in the studied muscles and blood of rats after the application of C60 fullerene and NAС plays a key role in the long-term residual effect of C60 fullerene. This indicates prolonged kinetics of C60 fullerenes elimination from the body, which contributes to their long-term (at least 2 days) compensatory activation of the endogenous antioxidant system in response to muscle stimulation, which should be considered when developing new therapeutic agents based on these nanoparticles.

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Prestatiebevorderende middelen in de sport

Cited by 7 publications

References 72 publications

Moderate Intensity Exercise Reduces Side Effects of Cancer Therapy and Maintains Cardiorespiratory Fitness in Male Breast Cancer Patients: Findings from the BRECA Male Crossover Study

Moderate Intensity Exercise Reduces Side Effects of Cancer Therapy and Maintains Cardiorespiratory Fitness in Male Breast Cancer Patients: Findings from the BRECA Male Crossover Study

Body Loading during an Intensive Yoga Exercise Routine and a Cycle Ergometer Test

The Residual Effect of C60 Fullerene on Biomechanical and Biochemical Markers of the Muscle Soleus Fatigue Development in Rats

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