Presumed idiopathic outer lamellar defects of the fovea and chronic solar retinopathy: an OCT and fundus autofluorescence study

dell’Omo, Roberto; Konstantopoulou, K.; Wong, Roger; Pavésio, Carlos

doi:10.1136/bjo.2009.157719

Cited by 26 publications

(19 citation statements)

References 24 publications

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“…This damage is responsible for the reduced lipofuscin content of the RPE cells, which follows from the reduced phagocytosis of photoreceptor outer segments due to a disruption of the outer segments-to-RPE interdigitation [9]. Although a hyperautofluorescent ring surrounding the reduced central autofluorescence has been described once previously [8], to the best of our knowledge, our study is the first to provide a reasonable explanation for this finding. The damage to the visual photo pigments or the sensitive cones by solar radiation induces a lack of normal outer segment processing [9], which can lead to increased accumulation of outer segments in the outer retina and subretinal space, as was revealed by SD-OCT in both of our cases.…”

Section: Discussionsupporting

confidence: 70%

“…This was encircled by a faint hyperautofluorescent ring, which ruled out pseudovitelliform dystrophy. Well-demarcated areas of hypoautofluorescence that correlate to loss of the IS/OS junction have been described, although this was hypothesized to be due to RPE cell loss [8]. However, none of the eyes of our patients showed atrophy of the RPE; instead, they showed a slight reduction of the reflectivity that was documented by SD-OCT.…”

Section: Discussionmentioning

confidence: 62%

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Solar Retinopathy: A Multimodal Analysis

Bruè

Mariotti

Franco

et al. 2013

Case Reports in Ophthalmological Medicine

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Purpose. Solar retinopathy is a rare clinical disturbance, for which spectral-domain optical coherence tomography (SD-OCT) findings are not always consistent. We report on two cases of solar retinopathy and discuss its differential diagnosis. Methods. This is an observational case study. Results. A 12-year-old female was referred to ophthalmology for bilateral scotoma. Visual acuity was 20/50 in both eyes. Fundus examination was unremarkable, except for slight yellowish material in the central macula, bilaterally. SD-OCT revealed juxtafoveal microcystic cavities in the outer retina, interruption of the external limiting membrane and the inner and outer segment junctions, with disorganized material in the vitelliform space. Fundus autofluorescence showed hypoautofluorescence surrounded by a relatively hyperautofluorescent ring, bilaterally. Similar clinical and morphological findings were detected in a 27-year-old male. Conclusions. Solar retinopathy has a subtle presentation and patients often deny sun-gazing. SD-OCT and fundus autofluorescence are noninvasive and useful tools for its diagnosis.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 62%

Solar Retinopathy: A Multimodal Analysis

Bruè

Mariotti

Franco

et al. 2013

Case Reports in Ophthalmological Medicine

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“…Ophthalmologists should ask patients with unexplained foveal yellow spots or outer lamellar macular changes on OCT imaging about inhalation of poppers. 4 Surveillance for this matter in the United Kingdom may be of merit. …”

Section: Commentmentioning

confidence: 99%

‘Poppers maculopathy’—an emerging ophthalmic reaction to recreational substance abuse

Davies

Kelly

Bhatt

2012

Eye

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“…Reduction of the content of lipofuscin, the main fluorophore of the RPE, has been documented following light-induced loss of photoreceptors. [4]…”

Section: Discussionmentioning

confidence: 99%

Unusual optical coherence tomography and fundus autofluorescence findings of eclipse retinopathy

Chen

Hwang

et al. 2012

Indian J Ophthalmol

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A 63-year-old female patient complained of dimness in the central field of vision in the left eye after viewing an annular partial eclipse without adequate eye protection on 22 July 2009. Fundoscopy showed a wrinkled macular surface. Fundus autofluorescence study revealed well-demarcated hyperautofluorescence at the fovea. Optical coherence tomography demonstrated tiny intraretinal cysts. Fluorescein angiography and indocyanine green angiography were unremarkable. Epimacular membrane developed in the following month with deteriorated vision. Vitrectomy, epiretinal membrane and internal limiting membrane peeling were performed. Vision was restored to 20/20 after the operation. Direct sun-gazing may damage the retinal structures resulting in macular inflammation and increased focal metabolism, which explains the hyperautofluorescence. It may also induce epimacular membrane. Fundus autofluorescence might represent a useful technique to detect subtle solar-induced injuries of the retina. The visual prognosis is favorable but prevention remains the mainstay of treatment. Public health education is mandatory in reducing visual morbidity.

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Presumed idiopathic outer lamellar defects of the fovea and chronic solar retinopathy: an OCT and fundus autofluorescence study

Cited by 26 publications

References 24 publications

Solar Retinopathy: A Multimodal Analysis

Solar Retinopathy: A Multimodal Analysis

‘Poppers maculopathy’—an emerging ophthalmic reaction to recreational substance abuse

Unusual optical coherence tomography and fundus autofluorescence findings of eclipse retinopathy

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