Presumed pseudobacteremia outbreak resulting from contamination of proportional disinfectant dispenser

Siébor, Eliane; Llanes, Catherine; Lafon, Ingrid; Ogier-Desserrey, A.; Duez, Jean-Marie; Péchinot, A.; Caillot, Denis; Grandjean, Marcus; Sixt, Nathalie; Neuwirth, Catherine

doi:10.1007/s10096-007-0260-1

Cited by 32 publications

(30 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as water has been reported as a common environmental source of P. aeruginosa from which soaps can be easily contaminated, 17 we hypothesized that water would be a possible cause of soap contamination, even if our probes of tap water were repetitively negative.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiological investigation of an outbreak of Pseudomonas aeruginosa infection in an SCT unit

Fanci

Bartolozzi

Sergi

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Molecular epidemiological investigation of an outbreak of Pseudomonas aeruginosa infection in an SCT unit

Fanci

Bartolozzi

Sergi

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

“…Confounding the diagnosis of P. fluorescens bacteremia is the well-described phenomenon of "pseudobacteremia" due to environmental contamination of blood culture collection bottles and equipment by the organism (175)(176)(177)(178)(179)(180)(181)(182). Indeed, in a systematic review of the medical literature, more positive P. fluorescens blood culture results were attributable to pseudobacteremia (175)(176)(177)(178)(179)(180)(181)(182) than to true bacteremia (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(183)(184)(185)(186)(187)(188)(189).…”

Section: P Fluorescens As a Disease-causing Agentmentioning

confidence: 99%

“…Indeed, in a systematic review of the medical literature, more positive P. fluorescens blood culture results were attributable to pseudobacteremia (175)(176)(177)(178)(179)(180)(181)(182) than to true bacteremia (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(183)(184)(185)(186)(187)(188)(189). Sources have included blood culture bottles cleaned with contaminated disinfectant (179) and, most commonly, contaminated blood collection tubes used prior to culture bottle inoculation (176,178,(180)(181)(182). Despite not reflecting "true" human pathology, pseudobacteremia is a legitimate clinical problem, resulting in diagnostic confusion for clinicians and inappropriate antibiotic exposure for patients (181).…”

Section: P Fluorescens As a Disease-causing Agentmentioning

confidence: 99%

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

et al. 2014

View full text Add to dashboard Cite

SUMMARY Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have identified it at low levels in the indigenous microbiota of various body sites. With recent advances in comparative genomics, many isolates originally identified as the “species” P. fluorescens are now being reclassified as novel Pseudomonas species within the P. fluorescens “species complex.” Although most widely studied for its role in the soil and the rhizosphere, P. fluorescens possesses a number of functional traits that provide it with the capability to grow and thrive in mammalian hosts. While significantly less virulent than P. aeruginosa , P. fluorescens can cause bacteremia in humans, with most reported cases being attributable either to transfusion of contaminated blood products or to use of contaminated equipment associated with intravenous infusions. Although not suspected of being an etiologic agent of pulmonary disease, there are a number of reports identifying it in respiratory samples. There is also an intriguing association between P. fluorescens and human disease, in that approximately 50% of Crohn's disease patients develop serum antibodies to P. fluorescens . Altogether, these reports are beginning to highlight a far more common, intriguing, and potentially complex association between humans and P. fluorescens during health and disease.

show abstract

“…There was also a previous report of an outbreak of catheter-related bacteremia in four oncology patients, the source of which was not identified (7). Furthermore, the organism has been linked to outbreaks of pseudobacteremia from the contamination of disinfectants (14) and blood collection tubes (10).…”

mentioning

confidence: 99%

Spread of Pseudomonas fluorescens Due to Contaminated Drinking Water in a Bone Marrow Transplant Unit

et al. 2011

View full text Add to dashboard Cite

Pseudomonas infections are an important cause of morbidity and mortality in immunocompromised patients. We present here data for the spread of Pseudomonas fluorescens caused by a contaminated drinking water dispenser in a bone marrow transplant unit. Over a 1-month period we observed a sharp increase in the isolation of P. fluorescens from weekly pharyngeal surveillance swabs. Environmental samples were taken from a variety of water sources throughout the unit. These samples were cultured on cetrimide agar medium, and isolates were epidemiologically characterized by antibiotic susceptibility patterns and molecular typing methods. Nine patients became colonized with P. fluorescens, and six out of the nine developed febrile neutropenia. P. fluorescens was cultured after the filtration of 100 ml of drinking water from one of two stand-alone chiller units supplying cooled bottled water to the bone marrow transplant unit. All other environmental samples were negative. There were no further cases of P. fluorescens colonization after the contaminated dispenser was removed. Molecular typing showed that all P. fluorescens isolates were identical by both random amplification of polymorphic DNA PCR and pulsed-field gel electrophoresis. We recommend that such bottled water supplies not be used in high-risk areas or be subject to regular microbiological monitoring.

show abstract

Presumed pseudobacteremia outbreak resulting from contamination of proportional disinfectant dispenser

Cited by 32 publications

References 13 publications

Molecular epidemiological investigation of an outbreak of Pseudomonas aeruginosa infection in an SCT unit

Molecular epidemiological investigation of an outbreak of Pseudomonas aeruginosa infection in an SCT unit

Microbiology, Genomics, and Clinical Significance of the Pseudomonas fluorescens Species Complex, an Unappreciated Colonizer of Humans

Spread of Pseudomonas fluorescens Due to Contaminated Drinking Water in a Bone Marrow Transplant Unit

Contact Info

Product

Resources

About