Presumed Roles of APRO Family Proteins in Cancer Invasiveness

Ikeda, Yuka; Taniguchi, Kurumi; Sawamura, Haruka; Yoshikawa, Sayuri; Tsuji, Akira; Matsuda, Satoru

doi:10.3390/cancers14194931

Cited by 4 publications

(4 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, several APRO family proteins could cooperate with the poly (A) ribonuclease complex [ 68 , 69 ]. These APRO family proteins (Btg1, Btg2, Tob1, and Tob2) might be key modulators of microRNAs [ 70 ], which may be extremely involved in the regulation of immune cells [ 71 ]. Therefore, APRO family proteins have been shown to be involved in immune-related disorders, including ulcerative colitis and cancer [ 72 , 73 , 74 ].…”

Section: Immune Pathway and Cardiac Arrhythmiasmentioning

confidence: 99%

Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update

Suga,

Ikeda,

Yoshikawa

et al. 2023

Genes

Self Cite

View full text Add to dashboard Cite

Non-coding RNAs (ncRNAs) are indispensable for adjusting gene expression and genetic programming throughout development and for health as well as cardiovascular diseases. Cardiac arrhythmia is a frequent cardiovascular disease that has a complex pathology. Recent studies have shown that ncRNAs are also associated with cardiac arrhythmias. Many non-coding RNAs and/or genomes have been reported as genetic background for cardiac arrhythmias. In general, arrhythmias may be affected by several functional and structural changes in the myocardium of the heart. Therefore, ncRNAs might be indispensable regulators of gene expression in cardiomyocytes, which could play a dynamic role in regulating the stability of cardiac conduction and/or in the remodeling process. Although it remains almost unclear how ncRNAs regulate the expression of molecules for controlling cardiac conduction and/or the remodeling process, the gut microbiota and immune system within the intricate networks might be involved in the regulatory mechanisms. This study would discuss them and provide a research basis for ncRNA modulation, which might support the development of emerging innovative therapies against cardiac arrhythmias.

show abstract

Section: Immune Pathway and Cardiac Arrhythmiasmentioning

confidence: 99%

Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update

Suga,

Ikeda,

Yoshikawa

et al. 2023

Genes

Self Cite

View full text Add to dashboard Cite

show abstract

“…Diet is known to impact health, lifespan, disease, and cancer incidence. Altered metabolism is a hallmark of cancer and inspires novel therapeutic strategies; in studies comparing cancer stem cells to non-cancer stem cells, no universal metabolic patterns have emerged [ 67 ]. Cancer and non-cancer stem cells preferentially use glycolysis or oxidative phosphorylation depending on the tumor type and model system used, precluding the assessment of microenvironment effects, and the metabolic adaptation of cancer stem cells has emerged as a particularly relevant step during metastatic colonization [ 67 ].…”

Section: Dietary Intervention Impacting Fatty Acid Metabolites and Th...mentioning

confidence: 99%

“…Altered metabolism is a hallmark of cancer and inspires novel therapeutic strategies; in studies comparing cancer stem cells to non-cancer stem cells, no universal metabolic patterns have emerged [ 67 ]. Cancer and non-cancer stem cells preferentially use glycolysis or oxidative phosphorylation depending on the tumor type and model system used, precluding the assessment of microenvironment effects, and the metabolic adaptation of cancer stem cells has emerged as a particularly relevant step during metastatic colonization [ 67 ]. Thus, the specific energy requirements of tumor cells, and, notably, of cancer stem cells during metastasis, may represent an opportunity for the treatment of late-stage disease [ 68 ].…”

Section: Dietary Intervention Impacting Fatty Acid Metabolites and Th...mentioning

confidence: 99%

Fatty Acid Metabolites and the Tumor Microenvironment as Potent Regulators of Cancer Stem Cell Signaling

Murai

Matsuda

2023

Metabolites

Self Cite

View full text Add to dashboard Cite

Individual cancer cells are not equal but are organized into a cellular hierarchy in which only a rare few leukemia cells can self-renew in a manner reminiscent of the characteristic stem cell properties. The PI3K/AKT pathway functions in a variety of cancers and plays a critical role in the survival and proliferation of healthy cells under physiologic conditions. In addition, cancer stem cells might exhibit a variety of metabolic reprogramming phenotypes that cannot be completely attributed to the intrinsic heterogeneity of cancer. Given the heterogeneity of cancer stem cells, new strategies with single-cell resolution will become a powerful tool to eradicate the aggressive cell population harboring cancer stem cell phenotypes. Here, this article will provide an overview of the most important signaling pathways of cancer stem cells regarding their relevance to the tumor microenvironment and fatty acid metabolism, suggesting valuable strategies among cancer immunotherapies to inhibit the recurrence of tumors.

show abstract

“…When, how, and why do their contradictory effects of VDR, PPAR, and ESR on cancer cells might occur? Although the precise mechanisms have not been elucidated yet, a reasonable explanation has been suggested in the similar inconsistency with anti-proliferative proteins, in which the roles of certain exosomes, matrix metalloproteinases (MMPs), and microRNAs might be involved [98].…”

Section: Vdr Ppar and Er Involved In Carcinogenesismentioning

confidence: 99%

Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies

Tsuji

Yoshikawa

Morikawa

et al. 2023

Exploration of Targeted Anti-Tumor Therapy

Self Cite

View full text Add to dashboard Cite

Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology. However, its effectiveness is limited in part due to the loss of effector cytotoxic T lymphocytes. Interestingly, supplementation of vitamin D could abolish the repressive effect of programmed cell death-ligand 1 (PD-L1) on CD8+ T cells, which might prevent the lymphocytopenia. In addition, vitamin D signaling could contribute to the differentiation of T-regulatory (Treg) cells associated with the expression of Treg markers such as forkhead box P3 (FOXP3) and CTLA-4. Furthermore, vitamin D may be associated with the stimulation of innate immunity. Peroxisome proliferator-activated receptor (PPAR) and estrogen receptor (ESR) signaling, and even the signaling from phosphoinositide-3 kinase (PI3K)/AKT pathway could have inhibitory roles in carcinogenesis possibly via the modulation of immune checkpoint molecules. In some cases, certain small molecules including vitamin D could be a novel therapeutic modality with a promising potential for the better performance of immune checkpoint blockade cancer therapies.

show abstract

Presumed Roles of APRO Family Proteins in Cancer Invasiveness

Cited by 4 publications

References 101 publications

Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update

Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update

Fatty Acid Metabolites and the Tumor Microenvironment as Potent Regulators of Cancer Stem Cell Signaling

Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies

Contact Info

Product

Resources

About