Preterm birth prevention: Evaluation of a prospective controlled randomized trial

Mueller-Heubach, Eberhard; Reddick, Debra; Barnett, Barbara; Bente, Robert

doi:10.1016/0002-9378(89)90183-x

Cited by 57 publications

(23 citation statements)

References 7 publications

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“…Attempts to understand rates of PTD in lower socioeconomic groups have not yet yielded benefit in terms of providing clues to the cause of PTB in general 30. Furthermore, attempts at intervention by improvement of social support mechanisms in this population have neither resulted in a decrease in the rates of PTD nor in improvement in outcome by any perinatal measures 34,35…”

Section: Introduction To Management and Issues Of Preterm Birthmentioning

confidence: 99%

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

How

Sibai

2008

TCRM

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Preterm birth is the leading cause of neonatal mortality and morbidity and long-term disability of non-anomalous infants. Previous studies have identifi ed a prior early spontaneous preterm birth as the risk factor with the highest predictive value for recurrence. Two recent double blind randomized placebo controlled trials reported lower preterm birth rate with the use of either intramuscular 17 alpha-hydroxyprogesterone caproate (IM 17OHP-C) or intravaginal micronized progesterone suppositories in women at risk for preterm delivery. However, it is still unclear which high-risk women would truly benefi t from this treatment in a general clinical setting and whether socio-cultural, racial and genetic differences play a role in patient's response to supplemental progesterone. In addition the patient's acceptance of such recommendation is also in question. More research is still required on identifi cation of at risk group, the optimal gestational age at initiation, mode of administration, dose of progesterone and long-term safety.

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Section: Introduction To Management and Issues Of Preterm Birthmentioning

confidence: 99%

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

How

Sibai

2008

TCRM

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“…[91][92][93] • Supplemental calcium has not been studied specifically in women with a prior preterm delivery. Its use in other populations has not reduced preterm birth.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

Care for Women with Prior Preterm Birth

Iams

2010

Preterm Birth

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Women who have delivered an infant between 16 and 36 weeks' gestation have an increased risk of preterm birth in subsequent pregnancies. The risk increases with more than 1 preterm birth and is inversely proportional to the gestational age of the previous preterm birth. African American women have rates of recurrent preterm birth that are nearly twice that of women of other backgrounds. An approximate risk of recurrent preterm birth can be estimated by a comprehensive reproductive history, with emphasis on maternal race, the number and gestational age of prior births, and the sequence of events preceding the index preterm birth. Interventions including smoking cessation, eradication of asymptomatic bacteriuria, progestational agents, and cervical cerclage can reduce the risk of recurrent preterm birth when employed appropriately. Keywordscerclage; prevention; progesterone; recurrent; preterm birth; risk estimation Efforts to reduce the incidence of preterm birth cannot yet be called successful but have produced sufficient information to justify management suggestions for clinicians, not only for strategies that do not work but also for those that do. The quality and number of clinical trials of interventions intended to reduce the incidence and/or morbidity of preterm birth has risen substantially in recent years, yielding data that can improve care for women at risk.An important advance has been the revision of the traditional model of preterm birth in which painful contractions or preterm membrane rupture were understood as the most common initial steps preceding cervical change. This concept has been challenged by observations from several clinical studies:• Drugs that arrest or inhibit uterine contractions can delay delivery but do not reliably reduce or prevent preterm birth. [1][2][3][4][5] • Assessment of contraction frequency is not a useful test to predict preterm birth, 6 and its use to detect and arrest initial or recurrent episodes of preterm labor does not affect the rate of preterm birth. [7][8][9] • Antibiotics that eradicate microorganisms associated with preterm birth also do not reliably reduce, and may sometimes increase, the incidence of preterm birth, especially in women with intact membranes. [10][11][12][13][14][15][16][17] • Progestational agents such as 17α-hydroxy-progesterone caproate reduce recurrent preterm birth in some women with a prior preterm birth, 18,19 especially those with early preterm birth 20 and short cervix, 21 but have no effect on preterm birth in multiple gestations. 22,23 NIH Public Access Author ManuscriptAm J Obstet Gynecol. Author manuscript; available in PMC 2013 May 09. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript• Cervical cerclage can reduce recurrent preterm birth in women with a prior preterm birth and short cervix 24,25 but increases the risk of preterm birth in women with multiple gestation who also have a short cervix. 24 These findings suggest the following 4 substantive changes in the "contractions change the cervi...

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“…Au Royaume-Uni, l'enquête confidentielle sur les morts maternelles a montré que les femmes issues de la minorité africaines venant de zones défavorisées étaient non seulement celles qui avaient le plus souvent un suivi prénatal insuffisant, mais que la mortalité maternelle était dans ce groupe 6 fois plus élevée que dans les autres [15]. Face à l'échec de programmes qui proposaient un suivi intensif aux femmes à risque de retard de croissance ou d'accouchement prématuré [16,17], l'idée d'une relation directe entre suivi sous-optimal et risque périnatal doit être tempérée. Peut-être faut-il considérer que cette association n'est pas entièrement liée à ce qu'apportent les visites prénatales ayant fait défaut, mais aussi en rapport avec les différences psychologiques et sociales existant entre les femmes se prêtant au suivi de grossesse et celles qui s'en tiennent à distance ou n'y ont pas accès [18].…”

Section: Inégalités Sociales De Suivi De Grossesseunclassified

Inégalités sociales en santé périnatale

Azria

2015

Archives de Pédiatrie

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Preterm birth prevention: Evaluation of a prospective controlled randomized trial

Cited by 57 publications

References 7 publications

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

Progesterone for the prevention of preterm birth: indications, when to initiate, efficacy and safety

Care for Women with Prior Preterm Birth

Inégalités sociales en santé périnatale

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