Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study

Abstract

Preterm births with placental malperfusion may mark women at higher cardiovascular disease risk.

Prenatal biochemical screening and long term risk of maternal cardiovascular disease: population based cohort study

“… 25 Hence, whether one or more of the abnormal analytes evaluated in this study are merely reflective of placental vascular disease or are persistently abnormal outside of pregnancy as a reflection of, or contributor to, vascular injury remains to be determined. 3 …”

“…Assessment of the secondary outcome of major adverse cardiovascular events was not censored on death. Hazard ratios were adjusted for variables chosen a priori, based on the existing literature, 3 4 5 6 7 including maternal age (continuous), gravidity (1, ≥2, missing), fifth of neighbourhood income (1, 2, 3, 4, 5, missing), rural residence (rural, urban, missing), ethnicity (Asian, oriental, black, white, Hispanic, other, missing), and gestational age (continuous), each at the time of prenatal biochemical screening, as well as maternal diabetes mellitus, chronic hypertension, renal disease, tobacco/illicit drug use, and dyslipidaemia within 365 days before or after the start of the index pregnancy (that is, within two years before time zero). “Asian” and “oriental” were classified together in some years, as were “Hispanic” and “other.” As maternal weight at the time of screening was missing for about 10% of pregnancies, we adjusted for it in an analysis restricted to women with non-missing weight (additional analysis 1).…”

“… 1 2 Placental vascular disease probably arises within the temporary interface of the trophoblast and endometrial decidua, resulting in adversity for mother and fetus, including pre-eclampsia, placental abruption, poor fetal growth, and preterm birth. 3 …”

“…Several risk factors for placental vascular disease, especially for pre-eclampsia, 3 4 are the same as those for cardiovascular disease (see supplementary file 1). A maternal placental syndrome in pregnancy seems to forecast a woman’s cardiovascular health in the years that follow, including premature onset before age 65 years of coronary artery disease, 5 6 heart failure, and dysrhythmias, 7 as well as death after coronary revascularisation.…”

The role of Chlamydia trachomatis in preterm delivery: a case-control study in Besat Hospital, Sanandaj, Iran (2018-2019)

“…Preterm delivery is an important subject in gynecology, obstetrics and pediatrics (1). Care and treatment of congenital complications in premature infants can be costly and accompanied by trauma and negative psychological impacts on the families.…”