Preterm labor: Stimulation of arachidonic acid metabolism in human amnion cells by bacterial products

Bennett, Phillip R.; Rose, Matthew P.; Myatt, Leslie; Elder, M. G.

doi:10.1016/0002-9378(87)90070-6

Cited by 179 publications

(44 citation statements)

References 9 publications

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“…Situations which result in tissue damage or widespread endotoxin production may be associated with premature parturition and there is now some rationale behind such conditions since they are associated with prostaglandin production (Bennett, Rose, Myatt, Elder, 1987;Lopez Bernal, Hansell, Caniete Soler, Keeling & Turnbull, 1988). If the affected areas are within the uteroplacental tissues then the likelihood of such PG synthesis resulting in premature labour is even greater.…”

Section: Maternal Influences and The Effect Of Environmental Factorsmentioning

confidence: 99%

Prenatal maturation, the timing of birth and how it may be regulated in domestic animals

Silver¹

1990

Experimental Physiology

115

111

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Section: Maternal Influences and The Effect Of Environmental Factorsmentioning

confidence: 99%

Prenatal maturation, the timing of birth and how it may be regulated in domestic animals

Silver¹

1990

Experimental Physiology

115

111

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“…ARA is mainly produced by the microorganism Mortierella fungi and the heterologous expression of the ARA by Escherichia coli (Higashiyama et al 2002;Bennett et al 1987;Barclay et al 1994) due to the fact that Mortierella fungi is more economically feasible, and E. coli is a good gene engineering carrier model and easy to be modified. Microalgae are photosynthetic, thus making them safer and environmentally friendly alternative source for ARA production.…”

Section: Introductionmentioning

confidence: 99%

Enhancing total fatty acids and arachidonic acid production by the red microalgae Porphyridium purpureum

Jiao

Chang

et al. 2016

Bioresour. Bioprocess.

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Objectives: This study investigated the effect of aeration rate and light intensity on biomass production and total fatty acids (TFA) accumulation by Porphyridium purpureum. The red microalgae is also known to accumulate considerable amount of arachidonic acid (ARA). Results:In artificial seawater medium, the highest yield of TFA (473.44 mg/L) was obtained with the aeration rate of 3 L/min and light intensity of 165 µmol/m 2 s, whilst the highest yield of ARA (115.47 mg/L) was achieved with the aeration rate of 3 L/min and light intensity of 110 µmol/m 2 s. It was found that higher aeration rate led to more biomass and TFA/ARA production. However, higher light intensity could contribute to biomass accumulation, but it was adverse for TFA and ARA biosynthesis. Conclusion:By optimizing two operating factors (i.e., light intensity and aeration rate), TFA and ARA production by P. purpureum was significantly improved. This research provides a potential alternative means for producing ARA.

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“…Most in vitro experiments that have explored the effects of microorganisms on the fetal membranes involve the exposure of ex vivo explants of these tissues to whole bacteria or their products (5,21,36). However, none of these experimental models considered the possible contribution of other local cells that are components of the choriodecidual microenvironment.…”

mentioning

confidence: 99%

Interaction between Pathogenic Bacteria and Intrauterine Leukocytes Triggers Alternative Molecular Signaling Cascades Leading to Labor in Women

et al. 2010

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Increased risk of preterm labor has been linked to cervicovaginal infection with Ureaplasma urealyticum and group B streptococci. Although various experimental models have been developed to study the role of amniochorion infection in preterm labor, they typically exclude the initial interaction between intrauterine leukocytes (recruited from decidual vessels into the avascular fetal membranes) and infecting bacteria. In this work, we ascertained whether inflammatory molecules secreted by bacterium-activated intrauterine leukocytes stimulate the amniochorion production of mediators involved in human labor. Using a two-step process beginning with placental circulating leukocytes as a proxy for intrauterine leukocytes, we found that coincubation of amniochorion explants with plasma from placental whole blood preincubated with group B streptococci resulted in a significant increase in tumor necrosis factor alpha (TNF-␣) and matrix metalloproteinase 9 (MMP-9) levels in tissue. Extensive changes in the connective tissue arrangement and a decrease in collagen content demonstrated the degradation of the extracellular matrix following this treatment. In contrast, plasma from blood preconditioned with U. urealyticum induced a highly significant secretion of interleukin-1␤ (IL-1␤) and prostaglandin E 2 (PGE 2 ) by the amniochorion without changes in the extracellular matrix organization or content. These data demonstrate that group B streptococci induce degradation of the amniochorion as a result of MMP-9 production, probably via TNF-␣, whereas U. urealyticum stimulates the secretion of PGE 2 , probably via IL-1␤, potentially stimulating myometrial contraction. Our study provides novel evidence that the immunological cells circulating within the uterine microenvironment respond differentially to an infectious agent, triggering alternative molecular signaling pathways leading to human labor.

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Preterm labor: Stimulation of arachidonic acid metabolism in human amnion cells by bacterial products

Cited by 179 publications

References 9 publications

Prenatal maturation, the timing of birth and how it may be regulated in domestic animals

Prenatal maturation, the timing of birth and how it may be regulated in domestic animals

Enhancing total fatty acids and arachidonic acid production by the red microalgae Porphyridium purpureum

Interaction between Pathogenic Bacteria and Intrauterine Leukocytes Triggers Alternative Molecular Signaling Cascades Leading to Labor in Women

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