Preterm Ovarian Hyperstimulation Syndrome: A Clinical Presentation of Three Cases

Vorgucin, Ivana; Katanic, Dragan; Kovacevic, Branka; Vislavski, Melanija; Bajkin, Ivana; Stanković, S; Internationals, Ommega

doi:10.15436/2380-5595.18.1802

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Ultrasound data of mini puberty ovarian maturation are dominant to uterine size. In the patient of this study, ovarian follicle size was over 10 mm, contrary to Kurtoğlu and Baştuğ's study 6 and similar to studies conducted by et al, Perez-Milicua et al, Vogiatzi et al, Mosallanejad et al, and Vorgucin et al 13,15,[18][19][20] In line with the results reported by Sedin et al, 13 in this study, despite the decrease in sex hormone levels and reduction of uterine size and ovarian volume, follicles with the size of 9 mm were observed on sonography, suggesting the development and atrophy of the follicles that are not necessarily related to puberty improvement.…”

Section: Discussionsupporting

confidence: 80%

“…The complete regression of puberty symptoms in our patient continued about 1 year due to severity of the primary presentation, although in other studies, it lasted from 2 weeks to 10 months due to lower severity of symptoms such as edema of the labia majora. 13,[18][19][20] Altogether, the severity of prematurity is not necessarily associated with the severity and variety of puberty presentation and the duration of symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the patients in similar articles also had longterm hospitalization due to bronchopulmonary dysplasia, recurrent prematurity apnea, primary pulmonary hypertension, PDA, ROP, and even ICH, all of which are the causes of inflammatory mechanisms in the body. 13,15,18,20 Synchronization of reduction in sex hormones and inflammatory markers (ferritin) may indicate that the inflammatory process is an irritant marker for exaggerated puberty during the infancy period (Table 1). Likewise, in the current case study, gradual regression of puberty symptoms was concomitant with the recovery of BPD symptoms and a decrease in oxygen demand.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Exaggerated Mini Puberty during Early Infancy of a Preterm Girl: A Case Report and Review of Literature

Davoodi

Ghobadi²,

Mahmoudi

et al. 2022

Arch Iran Med

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Mini puberty is the important period of infancy life that can have a serious impact on sexual development in both sexes. In the infants born very preterm and with extremely low birth weight, mini puberty changes including changes in clinical, hormonal, and imaging data are severe and long lasting, especially in girls. It can be called "exaggerated mini puberty". In this study, a 6-month preterm infant with bronchopulmonary dysplasia presented with periodic vaginal bleeding, Tanner stage 3 breast development, and Tanner stage 2 pubic hair. We did follow up clinical and para-clinical evaluations for the infant during one year and compared the obtained data with those of similar published articles. During one year of monitoring, the case gradually grew to the normal pre-pubertal state, without any hormonal suppressive treatment. Exaggerated mini puberty is a temporary physiologic state in very low birth weight (VLBW) preterm infants that does not require any extra hormonal and surgical interventions.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exaggerated Mini Puberty during Early Infancy of a Preterm Girl: A Case Report and Review of Literature

Davoodi

Ghobadi²,

Mahmoudi

et al. 2022

Arch Iran Med

View full text Add to dashboard Cite

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Different Faces of Minipuberty in Preterm Twin Girls: A Case Report and Review of the Literature

Pepe

Calafiore

Velletri

et al. 2023

JCM

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Minipuberty (MP) consists of a postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis, which occurs physiologically during the first months of life. In preterm infants, MP might lead to stronger hormonal stimulation, but specific literature is still scarce. We present the case of a pair of monochorionic diamniotic twin girls, born at 31 weeks of gestation and adequate for gestational age (AGA). At one month old, one of the twins presented with severe edema in the vulva and swelling of the major and minor labia. Laboratory evaluations highlighted increased LH, FSH and estradiol serum concentration. Pelvic ultrasonography and MRI showed a pubertal pattern. Brain imaging was unremarkable. During the one-year follow-up, a decreasing trend of hormonal levels was detected, together with the spontaneous regression of clinical and sonographic pubertal signs. The same hormonal workup was also performed on the other twin, who displayed mildly elevated gonadotropins and estradiol, without evidence of pubertal clinical signs. This case suggests that the amplitude of postnatal HPG activation might be exacerbated in preterm infants, with evidence of puberty changes in clinical, laboratory and sonography data. The spontaneous resolution, together with the exclusion of other causes of precocious puberty, is suggestive for MP of infancy.

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Preterm Ovarian Hyperstimulation Syndrome: A Clinical Presentation of Three Cases

Cited by 2 publications

References 18 publications

Exaggerated Mini Puberty during Early Infancy of a Preterm Girl: A Case Report and Review of Literature

Exaggerated Mini Puberty during Early Infancy of a Preterm Girl: A Case Report and Review of Literature

Different Faces of Minipuberty in Preterm Twin Girls: A Case Report and Review of the Literature

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