Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation

Milongo, David; Bascands, Jean-Loup; Huart, Antoine; Esposito, Laure; Breuil, Benjamin; Moulos, Panagiotis; Siwy, Justyna; Ramírez-Torres, Adela; Ribes, David; Lavayssière, Laurence; Bello, Arnaud Del; Muscari, Fabrice; Alric, Laurent; Bureau, Christophe; Rostaing, Lionel; Schanstra, Joost P.; Kamar, Nassim

doi:10.1111/liv.12763

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…Several studies have shown the importance of GFR monitoring during the first year after surgery as it allows the identification of patients at risk for CKD in the long term. However, we were able to demonstrate that very early creatinine elevation between D3 and D5, which did not meet the criteria for AKI as they are not sensitive enough, was correlated with poorer kidney function at 6 months to 1 year [66,131]. Similarly, the need for temporary dialysis has been identified as a source of CKD [51] in the long run.…”

Section: Post-operative Risk Factorsmentioning

confidence: 78%

“…At the same time, the risk of developing renal dysfunction is correlated with the type of liver cirrhosis. In fact, viral cirrhosis related to hepatitis [14], non-alcoholic steatohepatitis (NASH), alcoholic cirrhosis and primary biliary cholangitis are recognized as risk factors for post-transplantation renal dysfunction [10,66,70,73,75,122,123,129,131]. Conversely, patients with cirrhosis complicated by hepatocellular carcinoma develop fewer renal dysfunctions after transplantation [42,95].…”

Section: Risk Factors Related To the Liver Impairmentmentioning

confidence: 99%

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Kidney Failure after Liver Transplantation

et al. 2021

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One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liver transplantation, and liver transplant recipients are at a high risk of developing chronic kidney disease. The causes of renal dysfunction can be divided into three groups: pre-operative, perioperative and post-operative factors. To date, there is no consensus on the modality to evaluate the risk of chronic kidney disease after liver transplantation, or for its prevention. In this narrative review, we describe the outcome of kidney function after liver transplantation, and the prognostic factors of chronic kidney disease in order to establish a risk categorization for each patient. Furthermore, we discuss therapeutic options to prevent kidney dysfunction in this context, and highlight the indications of combined liver–kidney transplantation.

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Section: Post-operative Risk Factorsmentioning

confidence: 78%

Section: Risk Factors Related To the Liver Impairmentmentioning

confidence: 99%

Kidney Failure after Liver Transplantation

et al. 2021

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“…Most of the literature assessing variables associated with post-LT CKD examines clinical variables, rather than biomarkers. Only four studies were identified that assess the role of biomarkers in predicting post-transplant CKD [ 91 – 94 ]. Supplementary Table S4 summarizes baseline characteristics of the studies reviewed.…”

Section: Resultsmentioning

confidence: 99%

European Society for Organ Transplantation Consensus Statement on Biomarkers in Liver Transplantation

Berenguer,

de Martin,

Hessheimer

et al. 2023

Transpl Int

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Currently, one-year survival following liver transplantation (LT) exceeds 90% in large international registries, and LT is considered definitive treatment for patients with end-stage liver disease and liver cancer. Recurrence of disease, including hepatocellular carcinoma (HCC), significantly hampers post-LT outcomes. An optimal approach to immunosuppression (IS), including safe weaning, may benefit patients by mitigating the effect on recurrent diseases, as well as reducing adverse events associated with over-/under-IS, including chronic kidney disease (CKD). Prediction of these outcome measures—disease recurrence, CKD, and immune status—has long been based on relatively inaccurate clinical models. To address the utility of new biomarkers in predicting these outcomes in the post-LT setting, the European Society of Organ Transplantation (ESOT) and International Liver Transplant Society (ILTS) convened a working group of experts to review literature pertaining to primary disease recurrence, development of CKD, and safe weaning of IS. Summaries of evidence were presented to the group of panelists and juries to develop guidelines, which were discussed and voted in-person at the Consensus Conference in Prague November 2022. The consensus findings and recommendations of the Liver Working Group on new biomarkers in LT, clinical applicability, and future needs are presented in this article.

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“…The developed protein (β2‐microglobulin, CD40)/clinical (hepatitis C virus infection) model has excellent performance in both the modeling group and the validation group, which helps to screen high‐risk population of CKD for early Intervention. However, another prospective study focused on urine protein failed to identify peptide‐based biomarkers related to CKD after transplantation [43].…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of protein biomarkers in liver transplantation: A systematic review

Song

Xiong

et al. 2022

Proteomics Clinical Apps

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Liver transplantation is currently the preferred method for the treatment of advanced liver disease and early-stage hepatocellular carcinoma (HCC). Although advances in surgical techniques, immunosuppressive drugs and postoperative management have reduced the incidence of postoperative complications, how to effectively predict or diagnose postoperative complications earlier and reduce their incidence is still a clinical concern. We performed a comprehensive proteomics literature research to identified protein biomarkers in complications after liver transplantation. Seventeen studies met the inclusion criteria including ischemia reperfusion injury (IRI) (n = 4), acute rejection (AR) (n = 4), renal dysfunction (n = 4), HCC recurrence (n = 2), primary graft dysfunction (PGD) (n = 1), infection (n = 1), and liver fibrosis (n = 1). A total of 625 differentially expressed proteins (DEPs) have been reported between postoperative complications and controls, of which 63 have been validated by quantitative protein expression and 26 have been reported by at least two studies and showed consistently changes. The results of the bioinformation analysis show that the immune system, especially the innate immune system and cytokine signaling in immune system, is an important protein-mediated pathway that affects the prognosis of liver transplantation.

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Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation

Abstract: Urinary peptidome analysis before liver transplantation failed to identify a peptide pattern associated with the development of CKD at 6 months after liver transplantation.

Cited by 8 publications

References 31 publications

Kidney Failure after Liver Transplantation

Kidney Failure after Liver Transplantation

European Society for Organ Transplantation Consensus Statement on Biomarkers in Liver Transplantation

Prognostic value of protein biomarkers in liver transplantation: A systematic review

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