Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart

Tähepõld, Peeter; Valen, Guro; Starkopf, Joel; Kairane, Česlava; Zilmer, Mihkel; Vaage, Jarle

doi:10.1016/s0024-3205(01)00964-x

Cited by 65 publications

(64 citation statements)

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“…[9] Cisplatin causes significant oxidant loading to the kidney through both free radical formation and impaired antioxidant defense systems. [10] The hypothesis underlying the present study is that mild oxidative stress induced by oxygen pre-exposure [11] may enhance some endogenous defense mechanisms such as renal antioxidant systems and reduce subsequent cisplatin-induced kidney damage resulting from reactive oxygen species. Keeping this in view, we compared the degree of renal functional and structural injury in rats that were subjected to high-dose cisplatin administration with or without oxygen pretreatment.…”

Section: Introductionmentioning

confidence: 93%

“…[34] It should be noted that both in Atasoyu and Aydinoz studies, intermittent HBO therapy was started after the cisplatin injection. It could be proposed that short duration pretreatment with oxygen leads to a mild oxidative stress, [11] and this sub-lethal oxidative stress may in turn enhance endogenous defense mechanisms, such as antioxidant molecules and enzymes, against cisplatin-induced free radical injury.…”

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confidence: 99%

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Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

et al. 2010

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Cisplatin (CP) nephrotoxicity is mainly due to reactive oxygen species. Oxygen pre-exposure as a mild oxidative stress may enhance some endogenous defense mechanisms, so its effect on cisplatininduced acute renal failure was investigated in present study.Twenty-four rats were divided into four groups. The O 2 + CP and Air + CP groups were were subjected to i.p. injection of 5 mg/kg cisplatin, and in the Air + Saline and O 2 + Saline groups, saline was injected instead of cisplatin. O 2 + CP and O 2 + Saline groups were pretreated with oxygen (3h/d for two days), and the other two groups were pretreated with room air. Cisplatin was administered 24 h after last pretreatment session. Three days after cisplatin injection, plasma samples were obtained, and parts of kidney tissue were frozen for biochemical analysis or fixed in formalin for histological assessments. Preconditioning with oxygen prior to cisplatin administration led to reduced tubular necrosis and luminal cast formation and improvement of renal function, as was evidenced by significant reduction in plasma creatinine and urea levels. Oxygen pretreatment also significantly reversed cisplatin-induced reduction in renal catalase activity and glutathione level. It could be concluded that oxygen pretreatment could have a delayed protective effect against cisplatin nephrotoxicity, and that increased renal catalase activity may be involved in this protective effect of hyperoxia.

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Section: Introductionmentioning

confidence: 93%

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confidence: 99%

Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

et al. 2010

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“…Myocardial infarction size measured at the level of the mid-papillary heart muscles was scored by Masson's trichrome staining, as previously described, 23,24 and the images were analyzed in a blinded fashion with ImageJ 1.22 software (NIH Image). 25,26 Infarction size was expressed as a percentage of the total left ventricle myocardial area. An independent pathologist (Dr Feirt) who was blinded to the treatment received reviewed these measurements.…”

Section: Myocardial Infarction Modelmentioning

confidence: 99%

Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model

et al. 2002

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“…number of pharmacological interventions administered systemically, such as adenosine, bradykinin, adrenergic stimulation and catecholamines (Tahepold et al 2001, Heusch & Schulz 2002. Among the pharmacological interventions, opioid anaesthetics elicit a preconditioning response when injected immediately before sustained ischaemia (Schultz et al 1996, Fryer et al 2002.…”

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confidence: 99%

Intraperitoneal injection induces a delayed preconditioning-like effect in mice

et al. 2005

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SummaryWe hypothesized that intraperitoneal injections of anaesthetics or fluid per se might evoke a delayed preconditioning-like response in mice hearts isolated and Langendorff perfused 24 h later. To test this, mice were given opioid anaesthesia by intraperitoneal injections or sham treated and the hearts were harvested and subjected to global ischaemia and reperfusion 24 h later in series 1. In series 2, mice were subjected to intraperitoneal injection of Ringer, sham needle prick procedure, or no intervention 24 h before heart isolation. In series 3, intraperitoneal Ringer injection 24 h earlier was compared with the effects of classic preconditioning or no pretreatment of the isolated heart or no treatment. Heart function was measured in all series. At the end of reperfusion, hearts in series 1 and 2 were frozen and infarct size was estimated by triphenyltetrazolium chloride solution. In series 3, separate hearts were frozen for immunoblotting to detect phosphorylation of mitogen-activated protein (MAP) kinases. Cardiac activation of nuclear factor kappa B (NFkB) was measured using a NFkB luciferase firefly reporter mouse.The ischaemia-induced impairment of left ventricular function was attenuated by opioid anaesthesia injected 24 h earlier, which also reduced infarct size. Injection of fluid, but not the sham needle prick procedure, reduced infarct size. The functional protection afforded by classic preconditioning and Ringer pretreatment was comparable. Neither cardiac MAP kinases nor NFkB were influenced by the interventions. In conclusion, this study demonstrates a delayed preconditioning-like effect of the heart caused by intraperitoneal administration of opioid anaesthetics and of fluid only in the mouse. The mechanism of protection remains to be determined.

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Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart

Cited by 65 publications

References 0 publications

Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity

Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model

Intraperitoneal injection induces a delayed preconditioning-like effect in mice

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