Pretreatment Hematocrit Is Superior to Hemoglobin as a Prognostic Factor for Triple Negative Breast Cancer

Chen, Bo; Dai, De-Chang; Tang, Hailin; Ai, Xiaohong; Chen, Xi; Zhang, Xiaoyan; Li, Zhiyan; Xie, Xiaoming

doi:10.1371/journal.pone.0165133

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…Meanwhile, anemia is a common syndrome in cancer patients and there is growing evidence to support its close relationship with poor prognosis [ 22 , 23 ]. In GC, tumor bleeding, malabsorption, poor oral intake, and other factors related to tumor pathology may contribute to anemia.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer

et al. 2018

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BackgroundThis study investigated the prognostic value of diffuse splenic uptake on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in gastric cancer (GC) patients.MethodsA total of 134 pathology confirmed GC patients who underwent PET/CT for staging work-ups were enrolled. The maximal standardized uptake value (SUVmax) of primary tumor (Tmax), spleen (Smax), and spleen to liver uptake ratio (SLR) were measured. The prognostic value of PET-measured parameters in GC patients for predicting recurrence-free survival (RFS) and overall survival (OS) were assessed. And the relationships of the parameters with hematological and inflammatory parameters were also investigated.ResultsDuring follow-up period, 19 patients (14.1%) had disease recurrence and 12 (8.9%) died from GC. In univariate analysis, hematocrit (p<0.001 and p = 0.002), neutrophil to lymphocyte ratio (NLR; p = 0.021 and p = 0.040), AJCC staging (p<0.001 and p<0.001), adjuvant chemotherapy (p<0.001 and p<0.001), Tmax (p = 0.004 and p = 0.005), and SLR (p = 0.005 and p = 0.016) were significant prognostic factors for RFS and OS, whereas platelet to lymphocyte ratio (PLR; p = 0.034) was a significant prognostic factor for RFS. In multivariate analysis, only SLR was an independent prognostic factor for RFS (p = 0.018, adjusted HR = 3.011, 95% CI = 1.207–7.511). SLR were significantly associated with serum hematocrit level (r = -0.256, p = 0.002), PLR (r = 0.362, p = 0.001), and Tmax (r = 0.280, p = 0.001).ConclusionDiffuse splenic uptake on FDG PET/CT was correlated with the level of hematological and inflammatory parameters and was an independent predictor for RFS in GC.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer

et al. 2018

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“…Due to a long diagnosis time span and diverse TNM stages, patients received a great diversity of treatment modalities. Paclitexal-based combination chemotherapy, FEC (uorouracil/ epirubicin/cyclophosphamide), CMF (cyclophosphamide/methotrexate/fluorouracil), EC (epirubicin/ cyclophosphamide) and CAF/FAC (cyclophosphamide/doxorubicin/fluorouracil) were the main chemotherapy regimens [16]. Of the 3891 patients included in this analysis, 616 (15.8%) patients have died and 624 (16.0%) patients have experienced a recurrence.…”

Section: Clinicopathologic Features Of Bmi Groupsmentioning

confidence: 99%

Adverse effects of being underweight on young female breast cancer patients with lymph node metastases

et al. 2020

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Background: This study aimed to examine the effect of underweight in breast cancer. Methods: We performed a retrospective analysis of 3891 female patients diagnosed with primary breast cancer (I-IV stages). Body mass index (BMI) defined by World Health Organization criteria as follow: Underweight (UW; BMI<18.5 kg/m 2), normal weight (NW; BMI =18.5-24.9 kg/m 2) and overweight or obese (OW; BMI≥25 kg/m 2). We performed to evaluate the association between low BMI and clinical outcome in different age (18-40 years and over 40 years) breast cancer. Results: In our study, about 7% patients suffer from being underweight and 25% patients suffer from being overweight. Underweight is more prominent in young age group. Although no relationship was found between the recurrence rate and being underweight (HR 1.467(95 % CI 0.940-2.291), P=0.092 for disease-free survival), multivariate regression analysis confirmed that low BMI was an independent overall survival (OS) prognostic factor in young patients (HR 1.610(95 % CI 1.028-2.523), P=0.037 for OS). Further analysis showed the prognostic significance of underweight only seen in young patients with axillary lymph node metastasis or III-IV stage patients. Conclusions: Our results demonstrate the prognostic importance of low BMI in young breast cancer patients (under 40 years old) with lymph node metastases. The role of low BMI in breast cancer might depend on patients' age and clinical stage.

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“…HCT is one of the erythrocyte parameters. However, there have seldom been reports to show that HCT can be adopted as a screening index or a treatment effect predictor of certain diseases [ 6 ]. No reports showed that it can be used in lung cancer cases, either.…”

Section: Introductionmentioning

confidence: 99%

Low Hematocrit Is a Strong Predictor of Poor Prognosis in Lung Cancer Patients

Zhang

Qiao

et al. 2018

BioMed Research International

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Morbidity and mortality of lung cancer rank first in China and worldwide. Thus, noninvasive prognostic biomarkers are critical for clinicians to perform risk assessment in lung cancer patients prior to or during the course of treatment. In this study, we evaluated the prognostic value of preoperative hematocrit (HCT) count reduction on the long-term survival of lung cancer patients undergoing pneumonectomy and analyzed the correlation between reduced HCT counts and patients' clinicopathological features. A total of 1022 patients who underwent surgical treatment in Harbin Medical University Cancer Hospital, China, from February 2006 to December 2013, were enrolled in this study. The association between the clinicopathologic variables and HCT were evaluated by Mann-Whitney U-test and chi-square test, respectively. Survival curves were generated using Kaplan-Meier estimates, and differences between the curves were analyzed by a log-rank test. Multivariable analysis showed that high HCT (P < 0.001, HR: 0.595, 95% CI: 0.458–0.774) was favorable for patients' survival. Low HCT patients presented shorter mean months of OS than that of high HCT patients (P < 0.001). Male adenocarcinoma carcinoma patients with lower body mass index (BMI) and advanced tumor stage were more likely to observe low HCT. We identified for the first time reduced preoperative HCT count as an independent risk factor leading to poor prognosis in lung cancer patients who underwent surgical treatment.

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Pretreatment Hematocrit Is Superior to Hemoglobin as a Prognostic Factor for Triple Negative Breast Cancer

Cited by 12 publications

References 38 publications

Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer

Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer

Adverse effects of being underweight on young female breast cancer patients with lymph node metastases

Low Hematocrit Is a Strong Predictor of Poor Prognosis in Lung Cancer Patients

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