Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Abstract

The aim of this study was to evaluate the pretreatment hepatoprotective effect of the extract of marine-derived fungus Trichurus spiralis Hasselbr (TS) isolated from Hippospongia communis sponge on hepatotoxicity. Twenty-eight male Sprague-Dawley rats were divided into four groups (n = 7). Group I served as −ve control, group II served as the induced group receiving subcutaneously for seven days 0.25 mg heavy metal mixtures, group III received (i.p.) TS extract of dose 40 mg for seven days, and group IV served as the protected group pretreated with TS extract for seven days as a protection dose, and then treated with the heavy metal-mixture. The main pathological changes within the liver after heavy-metal mixtures administrations marked hepatic damage evidenced by foci of lobular necrosis with neutrophilic infiltration, adjacent to dysplastic hepatocytes. ALT and AST measurements show a significant increase in group II by 46.20% and 45.12%, respectively. Total protein, elevated by about 38.9% in induction group compared to the −ve control group, in contrast to albumin, decreased as a consequence of metal administration with significant elevation on bilirubin level. The results prove that TS extract possesses a hepatoprotective property due to its proven antioxidant and free-radical scavenging properties.

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

“…The animals were maintained in plastic cages, fed with standard laboratory chow obtained from the same unit, and water given ad libitum. The experimental method described by Abd El Moneam et al, [20] The animals were randomly divided into four (4) groups of 10 rats each and every group were placed in two cages. Group A: They received saline solution intraperitoneal (i.p) for one week and served as negative (-ve) control group.…”

Marine-derived fungi: diversity of enzymes and biotechnological applications

“… Kjer et al (2010) described a detailed protocol for the isolation, purification and characterization of endophytic marine-derived fungi, and Sponga et al (1999) discussed the isolation of fungi from marine sediments and sponges. Hallmann et al (2006) , Abdel-Monem et al (2013) , and Sette and Bonugli-Santos (2013) also mention the use of specific nutrients or compounds with particular toxicity levels for the selection of slow-growing fungi. For yeast isolation, alternative methods have been reported by Brauers et al (2000) and Schulz et al (2008) , and enrichment methods were applied by Dhevagi and Poorani (2006) and Mohan et al (2013) for the isolation of marine actinobacteria.…”

Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum

“…Endophytes have been the source of a number of bio-pharmacological compounds including those with antimicrobial, antitumor, anti-inflammatory, and antiviral activities ( Aly et al, 2008 ; Liu et al, 2008 ; Souza et al, 2008 ). In Egypt, endophytic fungi from aquatic, halophilic, medicinal plants, and marine resources have been studied by various investigators ( El-Morsy, 2000 ; Abdel-Motaal et al, 2010 ; Aly et al, 2011 ; Selim et al, 2011 ; Abdel-Monem et al, 2013 ; Salem and Abdel-Azeem, 2014 ).…”