Pretreatment lymphocyte–monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma

Hutterer, Georg C.; Sobolev, N; Ehrlich, Georg; Gutschi, T.; Stojaković, Tatjana; Mannweiler, Sebastian; Pummer, Karl; Zigeuner, Richard; Pichler, Martin; Dalpiaz, Orietta

doi:10.1136/jclinpath-2014-202658

Cited by 40 publications

(30 citation statements)

References 26 publications

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“…The association between LMR and OS was reported in 44 studies enrolling 14,984 patients with various cancer types [8, 10–13, 15–17, 19–21, 23–27, 29–33, 35–40, 42–46, 48, 49, 51, 53–56, 58–62]. Five of the eligible 44 studies (11%) reported a non-statistically significant hazard ratio.…”

Section: Resultsmentioning

confidence: 98%

“…Twenty-one studies provided sufficient data for the meta-analysis of the correlation between LMR and clinicopathological characteristics (Table 3) [10, 22–24, 29–32, 37, 39, 42, 43, 46, 51, 58–61]. Urothelial carcinoma, esophageal cancer, gastric cancer, renal cell carcinoma, lung cancer, DLBCL and Hodgkin's lymphoma were investigated in detail.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

et al. 2016

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Inflammation influences cancer development and progression, and a low lymphocyte to monocyte ratio (LMR) has been reported to be a poor prognostic indicator in several malignancies. Here we quantify the prognostic impact of this biomarker and assess its consistency in various cancers. Eligible studies were retrieved from PubMed, Embase and Web of Science databases. Overall survival (OS) was the primary outcome, cancer-specific survival (CSS), disease-free survival (DFS), recurrence-free survival (RFS), and progression-free survival (PFS) were secondary outcomes. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fifty-six studies comprising 20,248 patients were included in the analysis. Overall, decreased LMR was significantly associated with shorter OS in non-hematological malignancy (HR: 0.59, 95% CI: 0.53–0.66; P < 0.001) and hematological malignancy (HR: 0.44, 95% CI: 0.34–0.56; P < 0.001). Similar results were found in CSS, DFS, RFS and PFS. Moreover, low LMR was significantly associated with some clinicopathological characteristics that are indicative of poor prognosis and disease aggressiveness. By these results, we conclude that a decreased LMR implied poor prognosis in patients with cancer and could serve as a readily available and inexpensive biomarker for clinical decision.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

et al. 2016

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“…Oxidative stress, reperfusion damage, and increased reactive oxygen species (ROS) were observed in the lungs of patients with APE. 19 Also, LMR was associated with vascular diseases such as peripheral arterial diseases and coronary artery diseases. 12 Marchena et al observed that increased IL-6 levels were related with mortality in patients with APE.…”

Section: Discussionmentioning

confidence: 99%

Relation between lymphocyte to monocyte ratio and short‐term mortality in patients with acute pulmonary embolism

Ertem¹,

Yayla²,

Acar³

et al. 2016

Clinical Respiratory J

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“…Indeed, regardless of stage, the maintenance and development of the systemic inflammatory responses have been consistently linked to poorer prognosis 24,25. Although many organ systems act in the activation of systemic inflammatory responses, the common measurements of the magnitude of activation are circulating cellular components and acute-phase proteins.…”

Section: Discussionmentioning

confidence: 99%

A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer

Liu

Lin

et al. 2018

CMAR

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BackgroundRecent studies have revealed that preoperative fibrinogen and the neutrophil–lymphocyte ratio (NLR) are associated with poor outcome in gastric cancer (GC). We aimed to evaluate whether the fibrinogen and the NLR score had a consistent prognostic value for resectable GC.MethodsWe analyzed 1,293 consecutive patients who underwent curative surgery for GC. The F-NLR score was 2 for patients with hyperfibrinogenemia (>400 mg/dL) and elevated NLR (≥5.0), 1 for those with one abnormal index, and 0 for those with no abnormal indices.ResultsWe found that higher F-NLR scores were associated with larger tumor size, deeper tumor invasion and more lymph node metastasis (all P<0.05). In a multivariate analysis, F-NLR independently predicted postoperative survival (P<0.001). When stratified by tumor–node–metastasis (TNM) stage, the prognostic value of F-NLR was still maintained for stages I–II (P<0.001) and stage III (P=0.003). Of note, F-NLR also effectively stratified overall survival (OS) irrespective of age, adjuvant chemotherapy administration, tumor location and histological grade (all P<0.05). Furthermore, F-NLR and TNM stratified 5-year OS from 61% (F-NLR 0) to 15% (F-NLR 2) and from 92% (stage I) to 37% (stage III), respectively. Utilizing both F-NLR and TNM, 5-year OS ranged from 93% (F-NLR 0, TNM I) to 6% (F-NLR 2, TNM III).ConclusionThe F-NLR score independently predicts outcomes in GC patients after curative surgery. Therefore, it should be implemented in routine clinical practice for identifying more high-risk patients.

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Pretreatment lymphocyte–monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma

Cited by 40 publications

References 26 publications

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Relation between lymphocyte to monocyte ratio and short‐term mortality in patients with acute pulmonary embolism

A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer

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Pretreatment lymphocyte–monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma

Cited by 40 publications

References 26 publications

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

Relation between lymphocyte to monocyte ratio and short‐term mortality in patients with acute pulmonary embolism

A cumulative score based on preoperative fibrinogen and the neutrophil&ndash;lymphocyte ratio to predict outcomes in resectable gastric cancer

Contact Info

Product

Resources

About

A cumulative score based on preoperative fibrinogen and the neutrophil–lymphocyte ratio to predict outcomes in resectable gastric cancer