This study suggests MHR is independently associated with burden of coronary atherosclerosis.

LMR as a novel marker of inflammation seemed to be an independent predictor of short-term mortality in patients with APE.

Background and ObjectivesThe recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD).Subjects and MethodsSixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer's protocol.ResultsThe patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001).ConclusionSerum irisin level is an independent predictor of coronary artery severity in patients with stable CAD.

LMR was negatively correlated with serum C-reactive protein and neutrophil-to-lymphocyte ratio levels.

Objective:Hypertrophic cardiomyopathy (HCM) as a common genetic heart disease characterized by ventricular hypertrophy and myocardial fibrosis is significantly associated with a higher risk of fatal ventricular arrhythmic events (VAEs). We aimed to assess the interval between the peak and the end of the electrocardiographic T wave (Tp–e) and Tp–e/corrected QT (QTc) ratio as candidate markers of ventricular arrhythmias in patients with HCM.Methods:In this single-center, prospective study, a total of 66 patients with HCM and 88 controls were enrolled. The patients were divided into two groups: those with VAEs (n=26) and those without VAEs (n=40). Tp–e interval and Tp–e/QTc ratio were measured using a 12-lead electrocardiogram.Results:Tp–e interval was significantly longer and Tp–e/QTc ratio were significantly higher in HCM patients than in the controls. In correlation analysis, maximal left ventricular (LV) thickness also has a significant positive correlation with Tp–e interval (r=0.422, p<0.001) and Tp–e/QTc ratio (r=0.348, p<0.001). Finally, multivariable regression analysis showed that a history of syncope, Tp–e interval [OR (odds ratio): 1.060; 95% confidence interval (CI): 1.005–1.117); p=0.012], Tp–e/QTc ratio (OR:1.148; 95%CI:1.086–1.204); p=0.049], and maximal LV thickness were independent predictors of VAEs in patients with HCM.Conclusion:Our findings suggested that prolonged Tp–e interval and increased Tp–e/QTc ratio may be good surrogate markers for the prediction of VAEs in HCM.