Usefulness of Monocyte to HDL-Cholesterol Ratio to Predict High SYNTAX Score in Patients with Stable Coronary Artery Disease

Akboğa, Mehmet Kadri; Balcı, Kevser Gülcihan; Maden, Orhan; Ertem, Ahmet Göktuğ; Kırbaş, Özgür; Yayla, Çağrı; Acar, Berrin; Aras, Dursun; Kisacik, Halil; Aydoğdu, Sinan

doi:10.2217/bmm-2015-0050

Cited by 84 publications

(85 citation statements)

References 25 publications

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“…[4][5][6][7][8] As known, HDL-C plays an important role in antiinflammatory, antioxidant and antithrombotic progress, and can inhibit cytokine-induced expression of endothelial cell adhesion molecules. 9,10 It was reported that the MHR was independently associated with coronary atherosclerosis in patients with stable coronary artery disease; 11 however, there is inconsistency in changes in the lymphocyte count in MetS patients. Some studies reported that the number of lymphocytes was decreased in MetS patients, while other studies found that lymphocytes can take part in the pathogenesis of MetS.…”

Section: Introductionmentioning

confidence: 99%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

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Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

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Section: Introductionmentioning

confidence: 99%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Hence, the predictive performance of these biomarkers on the outcomes was limited. More recently, several efficient biomarkers, including gamma-glutamyl transferase (GGT) [25,26], GGT-to-platelet ratio (GPR) [27], mean platelet volume (MPV) [28,29], red blood cell distribution width (RDW) [30,31], and monocyte-to-HDL-C ratio [32], emerged. ALT, mainly derived from the liver, was considered as a marker of liver function.…”

Section: Discussionmentioning

confidence: 99%

ALT-to-Lymphocyte Ratio as a Predictor of Long-Term Mortality in Patients with Normal Liver Function Presenting Coronary Artery Disease after Undergoing PCI: A Retrospective Cohort Study

Zheng

Guo

Tang

et al. 2020

Journal of Interventional Cardiology

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Background. Alanine aminotransferase (ALT) is referred as liver transaminase and predominantly expressed by hepatocytes. Previous evidences showed that high levels of ALT were reversely associated with short- and long-term outcomes in patients with myocardial infarction. Besides, low lymphocyte has been demonstrated to be significantly correlated with adverse clinical outcomes in coronary artery disease (CAD). However, evidences about the relationship between ALT-to-lymphocyte ratio (ALR) and outcomes in CAD patients with normal liver function are limited. The aim of this study was to assess the relationship between ALR and clinical outcomes in patients with CAD. Methods. This is a retrospective cohort study, and a total of 3561 patients were enrolled in Clinical Outcomes and Risk Factors of Patients with CAD after percutaneous coronary intervention (PCI), from January 2013 to December 2017. After excluding patients with liver dysfunction, we finally enrolled 2714 patients. These patients were divided into two groups according to ALR value: the lower group (ALR < 14.06, n = 1804) and the higher group (ALR ≥ 14.06, n = 910). The average follow-up time was 37.59 ± 22.24 months. Results. We found that there were significant differences between the two groups in the incidence of all-cause mortality (ACM) (P<0.001) and cardiac mortality (CM) (P=0.010). Kaplan–Meier survival analysis suggested that CAD patients with higher ALR tended to have an increased accumulated risk of ACM and CM (log rank P<0.001 and P=0.006, respectively). Multivariate Cox regression analysis showed that ALR was an independent predictor of ACM (hazard ratio (HR) = 2.017 (95% confidence interval (CI): 1.289–3.158), P=0.002) and CM (HR = 1.862 (95% CI: 1.047–3.313), P=0.034). We did not find significant difference in the incidence of major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs) between the two groups after adjustments of confounders. Conclusion. Our results indicate that ALR is an independent predictor of long-term adverse outcomes in CAD patients who underwent PCI.

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“…The usefulness of the SYNTAX score while making revascularization decisions and in predicting adverse events in patients with coronary artery disease has been appreciated in a previous large-scale study [3]. It is known that endothelial dysfunction, oxidative stress, and many inflammatory biomarkers play a crucial role in the formation and progression of atherosclerosis [4][5][6]. Recently, the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-tomonocyte ratio (LMR) have been used as inflammatory biomarkers, and have been shown to be independent risk factors for atherosclerosis and cardiovascular events.…”

Section: To the Editormentioning

confidence: 99%

Novel inflammatory biomarkers for predicting high SYNTAX score

Akboğa

Kırbaş

Yayla

2016

Herz

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Usefulness of Monocyte to HDL-Cholesterol Ratio to Predict High SYNTAX Score in Patients with Stable Coronary Artery Disease

Abstract: This study suggests MHR is independently associated with burden of coronary atherosclerosis.

Cited by 84 publications

References 25 publications

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

ALT-to-Lymphocyte Ratio as a Predictor of Long-Term Mortality in Patients with Normal Liver Function Presenting Coronary Artery Disease after Undergoing PCI: A Retrospective Cohort Study

Novel inflammatory biomarkers for predicting high SYNTAX score

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