Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model

Chu, Kuang-En; Fong, Y.; Wang, David; Chen, Chao Fuh; Yeh, Diana

doi:10.1016/j.imbio.2017.10.011

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…Histological examination of edema, inflammatory cell infiltration, and the level of serum amylase and lipase were generally used to evaluate the severity of pancreatitis in vivo . Most studies considered water content as a key detecting index of edema, leading to the water content measurement in our study. Recent studies suggest that rosiglitazone prevents the development of SAP induced by caerulein and reduced induction of inflammation‐associated cytokines .…”

Section: Discussionmentioning

confidence: 99%

Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Nie

Cui

Guo

et al. 2018

J of Cellular Biochemistry

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Section: Discussionmentioning

confidence: 99%

Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Nie

Cui

Guo

et al. 2018

J of Cellular Biochemistry

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“…The right upper lobe lung tissue of the slaughtered mice was taken, blotted using a filter paper to remove water and blood from the surface, mass determined (wet weight), and then dried at 60°C for 72 h using a drying oven and weighed (dry weight). The tissue edema of the lungs was assessed by calculating the wet/dry weight (W/D) ratio (Chu et al 2018).…”

Section: The W/d Ratio Of Lungsmentioning

confidence: 99%

Effect of epicatechin on inflammatory cytokines and MAPK/NF-κB signaling pathway in lipopolysaccharide-induced acute lung injury of BALB/c mice

Li¹,

Fu²,

Fan³

et al. 2022

gpb

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This study evaluated the anti-inflammatory effect of epicatechin (EC) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) of tracheal installation in BALB/c mice. It was observed that EC could alleviate not only the histopathological changes but also decrease the wet/dry weight (W/D) ratio of lung tissues. It also suppressed the release of IL-1β, IL-6, and TNF-α in serum, bronchoalveolar lavage fluid (BALF), and lung tissues, respectively. A quantitative realtime PCR-based study further indicated that EC also inhibited the levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA in lung tissues. In addition, the Western blot report suggested that EC was closely involved in the inhibition of phosphorylation of ERK, JNK, p38, p65, and IκB in mitogen-activated protein kinases (MAPK) and nuclear factor-κB (NF-κB) signaling pathway. These results provide an experimental and theoretical basis for treating pulmonary inflammation by EC.

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“…Matrix metalloproteinases (MMPs), a family of 25 released and cell-surface-bound neutral proteinases, are zinc-dependent proteinases − that are involved in the degradation of structural components of the extracellular matrix (ECM) and are upregulated in various diseases . MMPs play a major role in lung organogenesis , and are actively present in a variety of inflammatory disorders, including lung immune disorders and even cancer .…”

Section: Introductionmentioning

confidence: 99%

In Vivo Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Imaging of MMP-2 in ALI/ARDS in LPS-Treated Mice

Alekhmimi,

Ramadan,

Cialla-May

et al. 2024

ACS Omega

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Matrix metalloproteinases (MMPs) are zinc-dependent proteinases that are capable of cleavage of extracellular matrix (ECM) proteins and enzymes and play an important role in lung dysfunction. Specifically, MMP-2 is produced in the lung by alveolar epithelial and endothelial cells and other immune cells, such as macrophages. MMP-2 regulatory pathway is initiated in alveolar macrophages during acute lung injury (ALI), which may increase pulmonary inflammation. Therefore, there is a critical need for fast and reliable techniques to track the acute respiratory distress syndrome (ARDS). Here, we describe near-infrared fluorescence resonance energy transfer (NI-FRET) MMP-2-based probe for the in vivo detection of ALI induced by lipopolysaccharides (LPS). LPS-induced MMP-2 was measured using near-infrared (NIR) imaging after 1, 2, 4, 5, and 24 h of LPS exposure. Our results were compared with the data obtained from ELISA and Western blotting, demonstrating that MMP-2 fluorescence probe provide a promising in vivo diagnostic tool for ALI/ARDS in infected mice.

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Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model

Cited by 6 publications

References 51 publications

Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice

Effect of epicatechin on inflammatory cytokines and MAPK/NF-κB signaling pathway in lipopolysaccharide-induced acute lung injury of BALB/c mice

In Vivo Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Imaging of MMP-2 in ALI/ARDS in LPS-Treated Mice

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