Pretreatment with aminophylline reduces release of Troponin I and neutrophil activation in the myocardium of patients undergoing cardioplegic arrest

Luo, Wanjun; Qian, Jianfang; Jiang, Haihe

doi:10.1016/j.ejcts.2006.11.042

Cited by 17 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the reperfusion phase of these cardiovascular events the crucial role of the inflammatory processes are widely accepted [183][184][185][186]. It has been shown that pretreatment with aminophylline before coronary artery bypass grafting or heart transplantation improved the mechanical and biochemical functions of the heart in human subjects [187,188]. Regarding caffeine, this drug possibly remains the most widely consumed psychoactive substance in the future.…”

Section: Discussionmentioning

confidence: 99%

Xanthine Derivatives in the Heart: Blessed or Cursed?

Szentmiklósi¹,

Cseppentö²,

Gesztelyi³

et al. 2011

CMC

View full text Add to dashboard Cite

Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. The main basic and human studies on the action of xanthines on impulse initiation and conduction, as well as the electrophysiological and mechanical activity of the working myocardium will be overviewed. The potential beneficial and harmful actions of the methylxanthines will be discussed in light of the recent experimental and clinical findings. The pharmacological features and clinical observations with adenosine receptor subtype-specific xanthine antagonists are also the subject of this paper. Based on the adenosine receptor-antagonistic activity of these compounds, it can be raised that xanthine derivatives might inhibit the cardioprotective action of endogenous adenosine on various subtypes (A(1), A(2A), A(2B) and A(3)) of adenosine receptors. Adenosine is an important endogenous substance with crucial role in the regulation of cardiac function under physiological and pathological conditions (preconditioning, postconditioning, ischemia/reperfusion injury). Recent clinical studies show that acute administration of caffeine or theophylline can inhibit various types of preconditioning in human subjects. There are no human studies, however, for the cardiovascular actions of long-term administration of these drugs. Upregulation of adenosine receptors and increased effectiveness of adenosine receptor-related cardiovascular functions have been observed after long-lasting treatment with methylxanthines. In addition, there are data indicating that blood adenosine level increases after long-term caffeine administration. Since the salutary actions (and also the adverse reactions) of a number of xanthine derivatives are repeatedly shown, the main goal is the development of novel structures that mimic the actions of the conventional methylxanthines as lead compounds, but their adenosine receptor subtype-specificity is higher, their water solubility is optimal, and the unwanted reactions are minimized.

show abstract

Section: Discussionmentioning

confidence: 99%

Xanthine Derivatives in the Heart: Blessed or Cursed?

Szentmiklósi¹,

Cseppentö²,

Gesztelyi³

et al. 2011

CMC

View full text Add to dashboard Cite

show abstract

“…In contrast, the lung was drastically infiltrated by neutrophils after CPB but to a lesser extent in the LIM group. Although the possibility that the low number of neutrophils within the heart muscle may directly disturb the contractility of the left ventricle is unlikely, it has been shown that high levels of cardiac troponine I, MPO, and neutrophil numbers within the cardiac sinus are related to ischemia/reperfusion damage [ 36 ]. Moreover, it is rather likely that the neutrophil infiltration of the pulmonary tissue during CPB significantly increases the pulmonary vascular resistance (no-reflow phenomenon) [ 8 - 15 ] that in turn may affect the preload of the left ventricle.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass

et al. 2007

View full text Add to dashboard Cite

show abstract

“…With continuous normothermic perfusion, we can avoid ischemia and all natural scavengers are provided [46], even though the complete depletion mechanism of free radicals remains unclear. A study by Luo [47] using aminophylline (theophylline), a xanthine derivative phosphodiesterase inhibitor with anti-inflammatory effects suggests that intracorporeal administration reduces the release of cardiac Troponin I (cTnI) and activation of neutrophils, improving cardiac function in patients undergoing cardiopulmonary bypass for coronary artery bypass grafting.…”

Section: Fig 1 -Myocardial Evolutionary Impairment Resulting From Ismentioning

confidence: 99%

Proteção miocárdica ao coração hipertrofiado: o eterno desafio

Cressoni¹,

Avanci²,

Braile³

et al. 2008

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

The myocardial protection allowed great advance in cardiac surgery, decreasing the mortality and making more feasible complex surgeries. Latterly the patient population elected for cardiac procedures has been changing towards elderly patients with ventricular function depressed and myocardial hypertrophy. The myocardial hypertrophy condition represents a great challenge since the beginning of the cardiac surgery. Several techniques have been described to protect the myocardial hypertrophy, however with no satisfactory results. In this manuscript we present the state of the art technique of myocardial protection. 98CRESSONI, ES ET AL -Myocardial protection to the hypertrophied heart: the eternal challenge Bras Cir Cardiovasc 2008; 23(1): 97-107 Rev

show abstract

Pretreatment with aminophylline reduces release of Troponin I and neutrophil activation in the myocardium of patients undergoing cardioplegic arrest

Abstract: Pretreatment with intravenous aminophylline reduces the subclinical myocardial injury and neutrophil activation in patients undergoing CPB for valve replacement.

Cited by 17 publications

References 21 publications

Xanthine Derivatives in the Heart: Blessed or Cursed?

Xanthine Derivatives in the Heart: Blessed or Cursed?

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass

Proteção miocárdica ao coração hipertrofiado: o eterno desafio

Contact Info

Product

Resources

About