Pretreatment with corticosteroids to prevent adverse reactions to nonionic contrast media.

Clinical Pharmacology, Uses, and Adverse Reactions of Iodinated Contrast Agents: A Primer for the Non-radiologist

“…33 Patients who received 2 doses of oral methylprednisolone, 32 mg each (one 6-24 hours before and another 2 hours before administration of an ICA), had a 4.5-fold reduction in the incidence of severe acute reactions (0.2% vs 0.9% in the corticosteroid and control groups; Pϭ.005). 33,34 Furthermore, the use of a nonionic monomeric agent provides greater protection from a severe reaction than the use of an ionic monomer with corticosteroid prophylaxis 35 ; however, severe reaction can still occur despite corticosteroid pretreatment and the use of low-osmolarity contrast media. 3,33,34 In patients at risk for acute reaction, pretreatment with corticosteroids is a common practice.…”

“…33,34 Furthermore, the use of a nonionic monomeric agent provides greater protection from a severe reaction than the use of an ionic monomer with corticosteroid prophylaxis 35 ; however, severe reaction can still occur despite corticosteroid pretreatment and the use of low-osmolarity contrast media. 3,33,34 In patients at risk for acute reaction, pretreatment with corticosteroids is a common practice. For adults at Mayo Clinic in Rochester, Minnesota, this consists of methylprednisolone, 32 mg orally, both 12 hours and 2 hours before the administration of an ICA (ie, "the Lasser prep").…”

“…For adults at Mayo Clinic in Rochester, Minnesota, this consists of methylprednisolone, 32 mg orally, both 12 hours and 2 hours before the administration of an ICA (ie, "the Lasser prep"). 34 "The Greenberger prep" is a commonly used alternative and consists of triple therapy with prednisone, 50 mg, administered orally 13 hours, 7 hours, and again at 1 hour before ICA administration, and both diphenhydramine, 50 mg, and ephedrine, 25 mg, administered orally 1 hour before contrast. 36 For mild reactions, because they are usually self-limiting and often present no major threat to the patient's well-being and long-term outcome, treatment is often symptomatic.…”

Improvement of Patient Safety and Inspection Satisfaction by Developing Pretreatment Process System with the Patients Who Reserved CT Enhance Examination

“…조영제 부작용 발생은 예견할 수 없으므로 조영제 부작용에 대한 과 거력이 있는 환자에게는 투여 전 예방적 약물인 항히 스타민제제, 스테로이드 제제 등을 적절하게 사용함으 로써 경증부터 전신적 반응의 발생률을 감소시킬 수 있다고 보고되고 있다 [6][7][8] . 또한 조영제에 의한 급성신 부전은 병원에서 발생하는 급성신부전의 11%정도를 차지하며 병원에서 발생하는 급성신부전의 세번째로 흔한 원인으로 알려져 있다.…”

Radiologic Imaging of Renal Masses

“…This is continued 12-24 hours after the examination to ensure that all contrast material has been excreted. [112] Diphenhydramine 50 mg oral may also be administered before contrast administration. All patients offered intravenous iodinated contrast studies should be counseled and informed of these associated risks.…”