Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects

Qu, Ze-qiang; Zhou, Yan; Zeng, Yuan-Shan; Yan, Li; Chung, Peter

doi:10.1016/s0895-3988(09)60062-3

Cited by 56 publications

(46 citation statements)

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“…Rhodiola rosea grows at high altitude and in cold regions and has long been used as a medicinal herb to prevent high altitude sickness in China due to its stressprotective and antioxidative activities (Qu et al 2009(Qu et al , 2012. Salidroside isolated from R. rosea is a phenolic glycoside and possesses various pharmacological properties (Bai et al 2014;Li and Chen 2001).…”

Section: Introductionmentioning

confidence: 99%

Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways

Tang

Gao

Mao

et al. 2016

Cell Stress and Chaperones

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Pulmonary fibrosis (PF) can severely disrupt lung function, leading to fatal consequences. Salidroside is a principal active ingredient of Rhodiola rosea and has recently been reported to protect against lung injures. The present study was aimed at exploring its therapeutic effects on PF. Lung fibrotic injuries were induced in SD rats by a single intratracheal instillation of 5 mg/kg bleomycin (BLM). Then, these rats were administrated with 50, 100, or 200 mg/kg salidroside for 28 days. BLM-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, and pro-inflammatory cytokine release, and oxidative stress damages in lung tissues were attenuated by salidroside in a dose-dependent manner. Furthermore, salidroside was noted to inhibit IκBα phosphorylation and nuclear factor kappa B (NF-κB) p65 nuclear accumulation while activating Nrf2-antioxidant signaling in BLM-treated lungs. Downregulation of E-cadherin and upregulation of vimentin, fibronectin, and α-smooth muscle actin (α-SMA) indicated an epithelial-mesenchymal transition (EMT)-like shift in BLM-treated lungs. These changes were suppressed by salidroside. The expression of TGF-β1 and the phosphorylation of its downstream targets, Smad-2/-3, were enhanced by BLM, but weakened by salidroside. Additionally, salidroside was capable of reversing the recombinant TGF-β1-induced EMT-like changes in alveolar epithelial cells in vitro. Our study reveals that salidroside's protective effects against fibrotic lung injuries are correlated to its anti-inflammatory, antioxidative, and antifibrotic properties.

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Section: Introductionmentioning

confidence: 99%

Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways

Tang

Gao

Mao

et al. 2016

Cell Stress and Chaperones

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“…rosea extract protects rats against cognitive deficits, neuronal injury and oxidative stress [2]. There have been reports that bioactive compounds in Rh.…”

Section: Discussionmentioning

confidence: 99%

“…We suggest that this effect of Rh. rosea involved modulation of cholinergic neurotransmission, and that it may be use as a potential agent in treatment of neurodegenerative diseases such as Alzheimer's disease [2] and other type of dementia and memory deterioration.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Rhodiola rosea extract on passive avoidance tests in rats

Getova

Bakova

2013

Open Medicine

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AbstractThe purpose was to evaluate the effects of extract of Rhodiola rosea on learning and memory processes on rats. The two series of experiments were carried out — on naïve rats and on rats with scopolamine-impaired memory. The passive avoidance tests were performed — step-down and step-through. The latency of reactions in seconds was observed in both tests. Naïve rats treated with the extract in showed the prolongation of latency of reaction of both step-down and step-through passive avoidances compared to the controls. Rats with scopolamine-impaired memory showed shorter latency of reaction in both passive avoidance tests compared to the controls. Rats treated with the extract of Rh. Rosea with scopolamine-impaired memory prolonged the latency in both passive avoidance tests compared to scopolamine group. It was found that the extract of Rh. Rosea improved performance during learning session, short and long memory retrieval tests in naïve rats. Scopolamine impaired the learning and memory retrieval of rats, but Rh. Rosea pretreatment improved performance and turned off the deterioration effect of scopolamine on these brain functions probably by non-specific mechanisms on cholinergic neurons. The studied plant extract can be a candidate for treatment of dementia and other memory disturbances.

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“…This precious perennial herbaceous plant distributed at high altitudes in the Polar Arctic and Alpine regions throughout Europe and Asia (Qu et al, 2009). It was reported that R. crenulata has multiple pharmacological *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Effect of salidroside on learning and memory ability of vascular dementia rats

Deng¹

2012

Afr. J. Pharm. Pharmacol.

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INTRODUCTIONIn the western world, vascular dementia (VaD) is the second most common form of adult-onset dementia after Alzheimer's disease (AD). It has an overall prevalence of 1.2 to 4.2% in people aged 65 years or older, and accounts for 10 to 50% of dementia cases, depending on the diagnostic criteria and study population (Knopman et al., 2003). In terms of symptomatology, VaD is characterized by progressive cognition decline, functional ability impairment and behavioral problems. VaD results mainly from ischemic injury or oligaemia to brain areas involved in cognition, memory and behaviour (Román, 2003).Rhodiola crenulata (Crassulaceae, Hongjingtian in Chinese) has been known as a medicinal plant for a long time. This precious perennial herbaceous plant distributed at high altitudes in the Polar Arctic and Alpine regions throughout Europe and Asia (Qu et al., 2009). It was reported that R. crenulata has multiple pharmacological *Corresponding author. E-mail: teng450052@126.com. activities such as, antioxidant (Panossian et al., 2010), antihypoxia (Ming, 1986, antifatigue (Shevtsov et al., 2003), antiapoptosis (Jung et al., 2002), anticancer (Kwon et al., 2008 and enhancement in learning and memory (Petkov et al., 1986). Recently, it was reported that the extract of R. crenulata could improve memory and behaviour of VaD rats and some mechanisms were also investigated (Chen et al., 2008a(Chen et al., , b, 2010Wang and Yang, 2008;Yang et al., 2008). However, the exact neuroprotective constituents in the extract of R. crenulata are still unclear. Salidroside (SD, p-hydroxyphenethyl-b-D-glucoside, C 14 H 20 O 7 , structure is shown in Figure 1) is one of the major active constituents in R. crenulata. It has been reported to possess various pharmacological properties including resisting anoxia, antiaging, anticancer, antiinflammation, antioxidative, antifatigue, antiviral, neuroprotective, hepatoprotective and cardioprotective effects (Diaz Lanza et al., 2001;Laremii and Grigor'eva, 2002;Kanupriya et al., 2005;Kelly, 2001;Kucinskaite et al., 2004;Ma et al., 2009;Nan et al., 2003;Wang et al., 2004Wang et al., , 2009Zhang et al., 2007).According to its neuroprotective activity and high content in R. crenulata, we assumed that SD might have some effects on learning and memory ability of VaD.In the current work, we established rat models of VaD by permanent ligation of bilateral common carotid artery and attempted to investigate the effects of SD on learning and memory ability of VaD rats by Y-maze test.

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Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects

Cited by 56 publications

References 44 publications

Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways

Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways

Effects of Rhodiola rosea extract on passive avoidance tests in rats

Effect of salidroside on learning and memory ability of vascular dementia rats

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