Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus

Al-Amin, Md.; Choudhury, Md. Faiyad Rahman; Chowdhury, Al Saad; Chowdhury, Tahsinur Rahman; Jain, Preeti; Kazi, Mohsin; Alkholief, Musaed; Alshehri, Sultan; Reza, Hasan Mahmud

doi:10.3389/fnins.2018.00384

Cited by 32 publications

(13 citation statements)

References 60 publications

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“…However, on LPS-challenge, it was increased, as has been shown by others, with such a challenge inducing astrocyte-released cytokines to express microglial NOS and prime microglia to produce to generate more radicals upon activation in all brain areas except the brain stem. Increased MDA activity on LPS challenge as observed here and by others 7,49 was not evident in the DENtreated group, which cannot be explained in the current study. In the liver, on the other hand, MDA was not affected by LPS challenge in controls at the dose of 1 mg/kg b.w.…”

Section: Fig 2: Effect Of Lps On Rearing and Grooming Behaviour In The Cage 2 Hr Post Lps Challenge (A+b) And In A Novel Open Field 4 Hr contrasting

confidence: 68%

Untitled

2021

IJPSR

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Bio behavioural aspects, immunity, and disease course are interlinked in a majority of conditions, particularly cancer. Peripheral stressors or their products regulate immunity by various ways. When there is added insult in an already compromised immune state such as cancer, as is done here using lipopolysaccharide (LPS), the system is said to be 'doublehit. Behavioural and brain tissue-associated biochemical changes on LPS challenge have been assayed in a Diethylnitrosamine (DEN)-treated Wistar rat model of hepatic cancer. Peripheral and central effects of LPS challenge have been screened at levels of neuro behaviours, liver enzymes and brain enzymes. While LPS challenge reduced exploratory and grooming behaviours across groups after 2 h, the effect disappeared on testing after 4 h, 6 h post LPS injection, rats demonstrated increased open arm time, reduced closed arm time and increased entries into both arms of the elevated plusmaze. DEN treatment induced similar results. LPS challenge in DEN-treated rats however, led to reduced open arm time, increased closed-arm time, and reduced entries into both arms. LPS challenge reduced locomotion in DENtreated rats, an effect not observed in controls. DEN treatment induced a reduction in brain AChE that was similar also on LPS challenge. There was a concomitant increase in nNOS in the DEN-treated group, with nNOS not affected by LPS challenge. Central and peripheral effects on antioxidants and lipid peroxidation as a result of DEN treatment and LPS challenge were observed. Results indicate that neuro behaviours, the activity of brain and liver tissue enzymes vary in cancer-induced, altered immune states. INTRODUCTION:The interface that facilitates adaptation and homeostasis while connecting intrinsically interlinked components of cancer, immune system, brain, and behaviour is well.

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Section: Fig 2: Effect Of Lps On Rearing and Grooming Behaviour In The Cage 2 Hr Post Lps Challenge (A+b) And In A Novel Open Field 4 Hr contrasting

confidence: 68%

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2021

IJPSR

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“…Total antioxidant capacity (TAC) was diminished ( Figures 12 and 13 ). Our results suggest that LPS-induced oxidative damage can be alleviated by the pretreatment with the G. oblongata marine extract and the effect is shown presumably by scavenging of the ROS by β-carotene among other bioactive secondary metabolites as an antioxidant by modulating the antioxidants status and lipid peroxidation by decreasing oxidative stress and increases the total antioxidant capacity, attenuating and protecting against LPS-induced inflammation as well as apoptosis [ 71 , 72 ]. In general, inflammatory activity is accompanied by inducible nitric oxide synthase, leading to the production of nitric oxide, which enhances the catalytic activity of COX2 via formation of the peroxinitrite anion.…”

Section: Discussionmentioning

confidence: 99%

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Nabil-Adam

Shreadah

2021

Bioscience Reports

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Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic cost, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally resulting in acute liver and/or kidney failure. Erythropoietin and its analogues are well known to influence the interaction between apoptosis and inflammation in liver and kidney. Objective: The aim of this study is to investigate and clarify the effect of G. Oblongata red algae on lipopolysaccharides (LPS)-induced acute liver and kidney injury of mice with endotoxemia and associated molecular mechanism from inflammation, apoptosis and oxidative stress levels. Results: The current study cleared out that treatment of rats with the G. Oblongata extract prior to LPS injection significantly lowered serum cytokines, including NF-κB, MPO and LPO, and improved liver apoptosis through suppressing protein tyrosine kinase signaling pathway, and that may be due to antibacterial activity as well antioxidant capacity of G. Oblongata extract. Conclusion: The current study was cleared out the possibility of administration of G. Oblongata red algae as a multi products source for biotechnological, medical, nutraceutical and pharmaceutical applications due to highly antioxidant and anti-inflammatory capacities even although more investigations are required for separating, purifying and characterizing these bioactive compounds.

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“…Determination of superoxide dismutase activity . The SOD level was estimated based on a modified previous protocol [ 36 , 37 ]. In short, the reaction mixture carried 50 mM sodium phosphate (pH 7.8), 13 mM methionine, 75 mM nitroblue tetrazolium (NBT), 2 mM riboflavin, 100 mM EDTA and 2 mL of hippocampal tissue homogenate.…”

Section: Methodsmentioning

confidence: 99%

Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies

et al. 2022

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Aging-induced memory impairment is closely associated with oxidative stress. D-Galactose (D-gal) evokes severe oxidative stress and mimics normal aging in animals. Curcumin, a natural flavonoid, has potent antioxidant and anti-aging properties. There are several proteins like glutathione S-transferase A1 (GSTA1), glutathione S-transferase omega-1 (GSTO1), kelch-like ECH-associated protein 1 (KEAP1), beta-secretase 1 (BACE1), and amine oxidase [flavin-containing] A (MAOA) are commonly involved in oxidative stress and aging. This study aimed to investigate the interaction of curcumin to these proteins and their subsequent effect on aging-associated memory impairment in two robust animal models: D-Gal and normal aged (NA) mice. The aging mice model was developed by administering D-gal intraperitoneally (i.p). Mice (n = 64) were divided into the eight groups (8 mice in each group): Vehicle, Curcumin-Control, D-gal (100mg/kg; i.p), Curcumin + D-gal, Astaxanthin (Ast) + D-gal, Normal Aged (NA), Curcumin (30mg/kg Orally) + NA, Ast (20mg/kg Orally) + NA. Retention and freezing memories were assessed by passive avoidance (PA) and contextual fear conditioning (CFC). Molecular docking was performed to predict curcumin binding with potential molecular targets. Curcumin significantly increased retention time (p < 0.05) and freezing response (p < 0.05) in PA and CFC, respectively. Curcumin profoundly ameliorated the levels of glutathione, superoxide dismutase, catalase, advanced oxidation protein products, nitric oxide, and lipid peroxidation in mice hippocampi. In silico studies revealed favorable binding energies of curcumin with GSTA1, GSTO1, KEAP1, BACE1, and MAOA. Curcumin improves retention and freezing memory in D-gal and nature-induced aging mice. Curcumin ameliorates the levels of oxidative stress biomarkers in mice. Anti-aging effects of curcumin could be attributed to, at least partially, the upregulation of antioxidant enzymes through binding with GSTA1, GSTO1, KEAP1, and inhibition of oxidative damage through binding with BACE1 and MAOA.

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Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus

Cited by 32 publications

References 60 publications

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Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Curcumin improves D-galactose and normal-aging associated memory impairment in mice: In vivo and in silico-based studies

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