Pretumor microenvironment of hepatocellular carcinoma: Cancerization or anticancerization?

Li, Genliang; Ni, Anni; Yu, Mengyao

doi:10.1016/j.gene.2019.03.034

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…ErbB3 binding protein 1 (Ebp1), also known as PA2G4, has been reported in several cancers, where it can serve as a pro-cancer regulatory factor or tumor suppressor. Bao et al (59) indicate that Ebp1/p38/HIF1 α The signaling pathway and Ebp1 mediated downregulation of p53 are involved in the occurrence of liver cancer. Therefore, Ebp1 and its downstream signaling pathways may be promising therapeutic targets for HCC treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Several lines of evidence suggest that the interaction between the tumor and microenvironment plays a crucial role in the likelihood of HCC progression and immunotherapy response. [ 59 , 60 ] Therefore, we evaluated the potential of PRGI to reflect immune cell infiltration and the prognostic value of different immune cell types. Generally speaking, a high abundance of activated memory CD4 + T cells contributes to immune responses and is associated with better prognosis, which also applies to CD8 + T cells.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic related gene index for predicting survival and immunotherapeutic effect of hepatocellular carcinoma

Du,

Zhang,

Yang

2023

Medicine

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Hepatocellular carcinoma (HCC) is the most common malignant liver tumor. It is an aggressive disease with high mortality rate. In this study, we investigated a new prognosis-related gene index (PRGI) that can predict the survival and efficacy of immunotherapy in patients with HCC. RNA-seq data and clinical data of HCC samples were obtained from the cancer genome atlas and ICGC databases. Prognosis-related genes were obtained using log-rank tests and univariate Cox proportional hazards regression. Univariate and multivariate analyses were performed on the overall survival rate of patients with prognosis-related genes and multiple clinicopathological factors, and a nomogram was constructed. A PRGI was then constructed based on least absolute shrinkage and selection operator or multivariate Cox Iterative Regression. The possible correlation between PRGI and immune cell infiltration or immunotherapy efficacy was discussed. Eight genes were identified to construct the PRGI. PRGI can predict the infiltration of immune cells into the tumor microenvironment of HCC and the response to immunotherapy. PRGI can accurately predict the survival rate of patients with HCC, reflect the immune microenvironment, and predict the efficacy of immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic related gene index for predicting survival and immunotherapeutic effect of hepatocellular carcinoma

Du,

Zhang,

Yang

2023

Medicine

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“…Tumor microenvironment is characterized by several pro-inflammatory cytokines, which can explain the onset of cancer by facilitating DNA damage, tumor growth, and angiogenesis. Thus, several pro-inflammatory markers were included in clinical scores for predicting patient survival or HCC recurrence [100,101]. The connection between platelet count and different types of solid tumors was described in several reports [102].…”

Section: Platelet-to-lymphocytes Ratio As Prognostic Index For Hccmentioning

confidence: 99%

Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics

Lai

Vitale

Manzia

et al. 2019

Cancers

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Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.

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Recent progress in molecular mechanisms of postoperative recurrence and metastasis of hepatocellular carcinoma

Niu¹,

Wang²,

Niu³

2022

World J Gastroenterol

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Pretumor microenvironment of hepatocellular carcinoma: Cancerization or anticancerization?

Cited by 4 publications

References 27 publications

Prognostic related gene index for predicting survival and immunotherapeutic effect of hepatocellular carcinoma

Prognostic related gene index for predicting survival and immunotherapeutic effect of hepatocellular carcinoma

Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics

Recent progress in molecular mechanisms of postoperative recurrence and metastasis of hepatocellular carcinoma

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