Prevalance of Pregnancy Associated Asymptomatic Bacteriuria: A Study Done in a Tertiary Care Hospital

Chandel, Lata; Kanga, Anil; Thakur, Kamlesh; Mokta, Kiran; Sood, Anuradha; Chauhan, Suvarcha

doi:10.1007/s13224-011-0071-2

Cited by 46 publications

(59 citation statements)

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“…Those women who show positive cultures should be treated as per antimicrobial sensitivity patterns of the bacteria which are isolated from their samples, to prevent maternal and foetal morbidities. In this study, the prevalence of asymptomatic bacteriuria was 7.3%, which was similar to those seen in various other studies [2,[9][10][11][12][13][14]. Neupane et al, (26%) and Imade et al, (45.3%) reported a higher prevalence [15,16].…”

Section: Resultssupporting

confidence: 90%

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Prevalence of Asymptomatic Bacteriuria and its Antibacterial Susceptibility Pattern Among Pregnant Women Attending the Antenatal Clinic at Kanpur, India

Sujatha¹

2014

JCDR

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IntrOductIOnUrinary Tract Infections (UTIs) commonly occur pregnancy, due to the morphological and physiological changes that take place in the genitourinary tract. UTIs are of two types, symptomatic and asymptomatic. Asymptomatic Bacteriuria (ASB) is defined as the presence of actively multiplying bacteria, which is greater than 105/ ml of urine within the urinary tract, excluding the distal urethra, at a time when the patient has no symptoms of a UTI [1]. ASB can be found in both pregnant and non-pregnant women. The prevalence of ASB was found to be 2-11% in pregnant women. Pregnancy enhances the progression from ASB to symptomatic bacteruria, which could lead to acute pyelonephritis in 20-50% of cases and to adverse obstetric outcomes such as prematurity, postpartum hypertensive disease, anaemia, UTIs, and higher foetal mortality rates, if it is left untreated [2,3]. Asymptomatic bacteriuria is a microbial diagnosis which is based on the isolation of a specified quantitative count of bacteria in a specimen of urine which is properly collected from a pregnant woman who does not have any signs or symptoms. Thus, urine culture is the gold standard screening technique for ASB which occurs during pregnancy [4,5]. The predominant organism that causes UTIs during pregnancy is Escherichia coli, which accounts for 80-90% of infections [6]. The relatively high prevalence of ASB during pregnancy, the significant consequences faced by women and their pregnancies, and the ability to avoid undesired outcomes with treatment, justify screening and treatment of ASB in pregnancy. The frequencies of isolated pathogens and their antimicrobial resistance patterns can vary in different geographical regions [7]. Therefore, the most common Microbiology Section causative agents should be investigated and communities should be made aware of their local antimicrobial resistances. The objective of this prospective study was to identify the prevalence of ASB, its most common causative microorganisms and the antibacterial susceptibilities of the isolated microorganisms among pregnant women who attended a tertiary care centre at Kanpur, India. MAterIAls And MethOdsThis was a prospective study which was conducted in the Department of Microbiology and Department of Obstetrics in Rama Medical College Hospital and Research Centre, over a period of 6 months, starting from 1 st November 2012 to 30 th April 2013. A total number of 300 pregnant women who attended antenatal clinic were included in this study. Pregnant women with a history of UTI symptoms (dysuria, frequency and urgency, etc), pregnancy induced diabetes mellitus/ hypertension, a history of antibiotic therapy taken in the previous two weeks, pyrexia of unknown origin, known congenital anomalies of the urinary tract, were excluded from this study. After getting clearance from the ethical committee, study was conducted. Informed consents were taken from all the patients. Urine samples were collected by standard mid-stream "clean catch" method from all the pregnant women, in sterile, wi...

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Section: Resultssupporting

confidence: 90%

“…Different studies done by Chandel et al, [11], Enayat et al, [12], Obirikorang et al, [13], Imade et al, [16], Khattak et al, [22], Jain et al, [23], as significant and insignificant according to the standard criteria. The organisms were identified by routine methods from the samples which showed significant bacteriuria.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Asymptomatic Bacteriuria and its Antibacterial Susceptibility Pattern Among Pregnant Women Attending the Antenatal Clinic at Kanpur, India

Sujatha¹

2014

JCDR

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“…Escherichia coli being a commensal of the intestine has common access through the faecal material into the female urinary tract. In this study, it was 44.26% which is on par with findings of Chandel et al, Khattak et al, Jain et al [20][21][22] All the gram-negative isolates of this study exhibited 100% sensitivity to Imipenem and meropenem. Moderate sensitivity was noted to amikacin, cefepime, and amoxyclavulanic acid.…”

Section: Discussionsupporting

confidence: 86%

Prevalence and associate risk factors of asymptomatic bacteriuria in pregnancy with bacterial pathogens and their antimicrobial susceptibility in a tertiary care hospital

Rohini

Reddy

Kandati

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Asymptomatic bacteriuria (ASB) is defined as the presence of actively multiplying bacteria, which is greater than 105/ ml of urine within the urinary tract excluding the distal urethra, at a time when the patient has no symptoms of UTI. Untreated and undiagnosed ASB is associated with adverse maternal and perinatal outcomes. The objective was to determine the profile, prevalence, microbiological isolates with susceptibility, and risk factors of ASB among pregnant women attending an antenatal clinic at a tertiary care hospital, Andhra Pradesh, India.Methods: A prospective cross sectional study with 200 pregnant women was conducted for a period of 3 months from January to March 2016. The mid- stream urine specimen was collected and processed from all the cases and social and baseline obstetric data was collected. The isolates from all the cases of ASB were identified by standard biochemical tests. Antimicrobial susceptibility was performed by Kirby- Bauer disc diffusion method and interpreted as per CLSI guidelines.Results: Prevalence of ASB in our study was 30.5%, mean age of the cases was 27.3± 2.9 years. ASB was most common in 25- 30 year’s age group, during 3rd trimester and among multiparous and multigravidae. Previous history of UTI, pre-eclampsia was having significant association among cases with ASB. Escherichia coli was the predominant isolate in the study followed by K. pneumoniae, CONS (Coagulase-Negative Staphylococci), Staphylococcus aureus, citrobacter and Enterococci.Conclusions: Undiagnosed and untreated asymptomatic bacteriuria is associated with complications during pregnancy. Hence routine screening of antenatal women during all trimesters must be considered in preventing the complications and adverse foetal outcomes particularly with known risk factors like increasing age, multiparity and previous history of UTI.

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“…Our findings agree with earlier studies where E. coli was found to be commonest isolate. 2 A number of observational studies have demonstrated the relationship between maternal symptomatic UTI and the risk of PTL and LBW but some of the studies failed to establish the association. 22,23 However, the association of ASB with maternal and foetal complications remains an area of continued debate.…”

Section: Discussionmentioning

confidence: 99%

“…2 The prevalence of ASB in pregnant women varies from 4% to 23.9% globally and the higher prevalence is attributed to lack of personal and environmental hygiene, socio-economic status, parity and ABSTRACT Background: The pregnant women are more commonly affected with asymptomatic bacteriuria (ASB) than nonpregnant women and its progression could lead to adverse maternal and perinatal outcomes. The study was designed with an aim to know the prevalence of ASB and its effects on maternal and perinatal outcome.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

et al. 2018

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INTRODUCTIONAsymptomatic bacteriuria (ASB) is a condition in which urine culture reveals a significant growth of pathogenic bacteria i.e. greater than 105 bacteria/mL without the presence of symptoms related to urinary tract infection (UTI).1 The pregnant women are more commonly affected than non-pregnant women due to various morphological, physiological changes and urinary stasis that occur during pregnancy due to the effect of progesterone. 2 The prevalence of ASB in pregnant women varies from 4% to 23.9% globally and the higher prevalence is attributed to lack of personal and environmental hygiene, socio-economic status, parity and ABSTRACT Background: The pregnant women are more commonly affected with asymptomatic bacteriuria (ASB) than nonpregnant women and its progression could lead to adverse maternal and perinatal outcomes. The study was designed with an aim to know the prevalence of ASB and its effects on maternal and perinatal outcome. Methods: In this prospective study, 300 antenatal women attending Anil Neerukonda Hospital were screened for ASB. Urine culture was performed using standardized Kirby-Bauer disc diffusion method on blood agar, Mac Conkey's agar for antibiotic sensitivity testing. The screened antenatal women were divided into two subgroups viz. asymptomatic bacteriuria positive (Group I) and asymptomatic bacteriuria negative (Group II) depending on the culture study and were followed till delivery for maternal and perinatal outcomes. Results: The prevalence of ASB was 11.33%. Out of 34 cases of ASB positive, 8 cases (23.5%) were delivered with birth weight <2500 grams as compared to 11 cases (4.1%) in unexposed cases (RR 5.68, 95% CI; 2.46-13.15; p<0.05). Preterm low birth was noticed in 5 (14.7%) cases of ASB positive pregnant women with compared to unexposed cases (RR 1.5, 95% CI; 0.61-3.65, p=0.36). Regarding maternal outcomes, premature labour was observed in 8 cases (23.5%) of ASB exposed women whereas 22 (8.3%) in non-exposed cases (RR 2.84, 95% CI; p=0.004). A significant number of women have developed hypertension (17.6%) and preeclampsia (8.8%) in ASB positive cases as compared to ASB negative cases (4.9% and 2.3% respectively). Conclusions: The prevalence of ASB was 11.33% in the present study. As one third of the cases were identified in early and late trimesters, regular and trimester wise screening need to be incorporated in routine antenatal screening for safe motherhood and new born health.

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Prevalance of Pregnancy Associated Asymptomatic Bacteriuria: A Study Done in a Tertiary Care Hospital

Cited by 46 publications

References 4 publications

Prevalence of Asymptomatic Bacteriuria and its Antibacterial Susceptibility Pattern Among Pregnant Women Attending the Antenatal Clinic at Kanpur, India

Prevalence of Asymptomatic Bacteriuria and its Antibacterial Susceptibility Pattern Among Pregnant Women Attending the Antenatal Clinic at Kanpur, India

Prevalence and associate risk factors of asymptomatic bacteriuria in pregnancy with bacterial pathogens and their antimicrobial susceptibility in a tertiary care hospital

Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

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