Prevalence and analysis of tobacco use disorder in patients diagnosed with lung cancer

Abstract

Introduction Tobacco use disorder (TUD), previously known as nicotine dependence, was associated with increased risk of lung cancer. However, little is known about the prevalence of TUD and symptom manifestation in smokers with lung cancer. Objectives The aim of the present study was to investigate the prevalence of TUD using DSM-5 diagnostic criteria in patients diagnosed with lung cancer and analyze their tobacco use characteristics. Methods A total of 200 histologically confirmed lung cancer patients who used tobacco within the prior 12-month period at the time of diagnosis were recruited for this study. Participants were assessed using interviewer-administered questionnaires to determine TUD symptoms and smoking-related behaviors, and self-administered Fagerstrom Test for Nicotine Dependence (FTND) was also administered. Results The prevalence of DSM-5 TUD was 92.0% (n = 184). Of a total of 200 subjects, 23 (11.5%), 35 (17.5%), and 126 (63.0%) were classified into mild, moderate, and severe TUD categories, respectively. A total of 19 (81.3%) moderate TUD and 98 (77.8%) severe TUD patients had attempted smoking cessation. Of these subjects, 21 (21.4%) severe TUD and 12 (63.2%) moderate TUD patients tried more than three times. The number of satisfied criteria under DSM-5 TUD was positively correlated with FTND score, cumulative lifetime smoking amount, and daily smoking levels. Conclusions Smokers diagnosed with lung cancer showed a high prevalence of DSM-5 TUD. Their heavy and consistent tobacco use suggests reduced motivation to abstain from smoking.

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

“…While CPD is associated with key markers of ND, such as cessation likelihood 13 , the FTND conveys additional valuable information by including 5 items in addition to CPD. FTND is meaningfully associated with tobacco use diagnostic criteria from the Diagnostic and Statistical Manual of Mental Disorders 14 , 15 and is more highly associated with withdrawal severity than is CPD 7 . Its validity may be due to the inclusion of the time-to-first-cigarette in the morning (TTFC) item, which appears to be especially strongly associated with relapse likelihood 16 – 18 and may be an especially informative measure of heritability of ND 19 .…”

Expanding the Genetic Architecture of Nicotine Dependence and its Shared Genetics with Multiple Traits: Findings from the Nicotine Dependence GenOmics (iNDiGO) Consortium

“…12 While CPD is associated with key markers of ND, such as cessation likelihood 13 , the FTND conveys additional valuable information by including 5 items in addition to CPD. FTND is meaningfully associated with tobacco use diagnostic criteria from the Diagnostic and Statistical Manual of Mental Disorders 14,15 and is more highly associated with withdrawal severity than is CPD. 7 Its validity may be due to the inclusion of the time-to-first-cigarette in the morning (TTFC) item, which appears to be especially strongly associated with relapse likelihood [16][17][18] and may be an especially informative measure of heritability of ND.…”

Is the diagnosis of lung cancer effective in decision of smoking cessation period?

“…One of the features that increase the risk of lung cancer is the age of starting smoking 26 . In the study of Paik et al, tobacco users diagnosed with lung cancer have did not find a significant age in their studies 27 . In our study, there was a significant relationship between smoking cessation after the diagnosis of lung cancer and the age of starting smoking.…”